DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfk and pfk1

DIOPT Version :9

Sequence 1:	NP_001246234.1	Gene:	Pfk / 36060	FlyBaseID:	FBgn0003071	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_595946.1	Gene:	pfk1 / 2539972	PomBaseID:	SPBC16H5.02	Length:	942	Species:	Schizosaccharomyces pombe

Alignment Length:	869	Identity:	376/869 - (43%)
Similarity:	522/869 - (60%)	Gaps:	58/869 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 LLSVKFNCKRHCIKLRSDSGDQKNDSPGEKNIQKDKSAQRCGKPINNLHNGFLNAVN-YSEKNAV 139
            ||.:........||.::...::|   |.|..::         .|:.|| .||.:..| ::..|..
pombe   107 LLDLLKQLSADAIKYQAFPNEKK---PDEVYVE---------DPLGNL-IGFSDRYNPFAHANLK 158

  Fly   140 KKKKS--APKRKCGKS---VDELRKCLRTMQDVIDFVHPVKPF-KDKGLAVFTSGGDSQGMNAAV 198
            |.::|  |...:.|.:   |:.|:|.  |..|        ||. ..|.:||.||||||.||||.|
pombe   159 KSEESGAASNLESGLATPVVETLKKA--TTSD--------KPAGVKKKIAVMTSGGDSPGMNAVV 213

  Fly   199 RACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRGGTIIGSARCQDFRERQGRL 263
            ||..|:||:.||..:.|.|||:|:|.|||.|::..|..|...:..|||:||:|||..||||.|||
pombe   214 RAVARIAIHRGCDAFAIYEGYEGLVQGGDMIKQLQWGDVRGWLAEGGTLIGTARCMAFRERPGRL 278

  Fly   264 KAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTITTEQQEKFNVLHIVGLVGS 328
            :||.|||..||.:::|.|||||||||::||.:|..|:.||...|.||.||.:.:..|.|||||||
pombe   279 RAAKNLISAGIDSIIVCGGDGSLTGADIFRSDWPGLVKELEDTKAITPEQAKLYRHLTIVGLVGS 343

  Fly   329 IDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGRHCGYLSVVAGIISEADYVF 393
            ||||...||:|||..::||||.||:|:|||||.||.|.||:||||||||:|:|:|.:.:.||:||
pombe   344 IDNDMSSTDVTIGAFSSLHRICEAVDSISSTAISHSRAFIVEVMGRHCGWLAVLAALATGADFVF 408

  Fly   394 LPESPPQ-ADWPDRLVLKLEQERSAGQRLNIVIVAEGAMDREGHPITAEDVKKVIDERLKHDARI 457
            :||.|.: ..|.|.|...|...|..|:|.:||||||||:|.|.:.|:.||:|.::.|||..|.|:
pombe   409 IPERPAEVGKWQDELCNSLSSVRKLGKRKSIVIVAEGAIDSELNHISPEDIKNLLVERLHLDTRV 473

  Fly   458 TVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDGNQAVRVPLMECVERTQAV 522
            |.||||||||.|.|:||:||...|.:|..|::.:|.|:...:|:::||:..|.||||.|:.|..|
pombe   474 TTLGHVQRGGIPCAYDRMLATLQGVDAVDAVLASTPDTPSPMIAINGNKINRKPLMEAVKLTHEV 538

  Fly   523 AKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKP-----PKENFDADGKGIEGYRLAVMHIGAP 582
            |.|:.:|::|.|::||...|...|.|::..|.::.     ||:         |..|:|::|:|||
pombe   539 ADAIEKKQFAHAMELRDPEFADYLHTWEGTTFIEDESHFVPKD---------ERMRVAIIHVGAP 594

  Fly   583 ACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIA-GNVRELGWSDVSGWVGQGGAYLGTKRTLPE 646
            |.|||:|.|:.||..:.||.....|::|..|.:. .::.||.|.||..|..:||:.:||.|..|:
pombe   595 AGGMNSATRAAVRYCLNRGHTPLAIDNGFSGFLRHDSIHELSWIDVDEWCIRGGSEIGTNRDTPD 659

  Fly   647 GKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPSTISNNVPGTEFSL 711
            ......|.:.::.||..|:||||||::.|..|:...|.|||.|.||:.:||:|||||||||||||
pombe   660 LDMGFTAFKFQQHKIDALIIIGGFEAFTALSQLESARVNYPSFRIPMAIIPATISNNVPGTEFSL 724

  Fly   712 GCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADAAYIYEEKFSIKDL 776
            ||||.||.:.|.||.|:|||..::|||||.|..||..||:||:.||..||.|.|..|:..|:..|
pombe   725 GCDTCLNAVMEYCDTIKQSASASRRRVFVCEVQGGRSGYIATVGGLITGASAIYTPEDGISLDML 789

  Fly   777 QQDVYHMASKMAEGVSRG----LILRNEKASENYSTDFIYRLYSEEGKGLFTCRMNILGHMQQGG 837
            ::|:.|:.:..|....|.    ||||||.||:.|:|:.|..:.|||....|:.|..:.||:||||
pombe   790 RKDIDHLKATFALEAGRNRAGQLILRNECASKVYTTEVIGNIISEEAHKRFSARTAVPGHVQQGG 854

  Fly   838 SPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFSPLVDL-IAE 901
            :|||.||....::|.:.:.:.     ....||.:.|  .|.:|.::||......||.:.|: ..|
pombe   855 NPTPMDRARAARLAMRAIRFF-----ETCRANDLGN--DPSSAVVIGIRGTGVSFSSVADVENNE 912

  Fly   902 TNFDQRIPKKQWWLRLRPLLRILA 925
            |..:.|.||..||..:..|:.|||
pombe   913 TEIEMRRPKNAWWRDMHNLVNILA 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_001246234.1	PFK	178..914	CDD:294137	345/747 (46%)
Pfk	NP_001246234.1	6PF1K_euk	180..929	CDD:274152	351/758 (46%)
pfk1	NP_595946.1	PFK	192..936	CDD:294137	349/759 (46%)
pfk1	NP_595946.1	6PF1K_euk	195..940	CDD:274152	351/758 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	347	1.000	Domainoid score	I177
eggNOG	1	0.900	-	-		E1_COG0205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	654	1.000	Inparanoid score	I122
OMA	1	1.010	-	-		QHG63571
OrthoFinder	1	1.000	-	-		FOG0000489
OrthoInspector	1	1.000	-	-		oto100671
orthoMCL	1	0.900	-	-		OOG6_100319
Panther	1	1.100	-	-	LDO	PTHR13697
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2168
SonicParanoid	1	1.000	-	-		X474
TreeFam	1	0.960	-	-
	13	12.860