Protein Alignment Pfk and Pfkm

DIOPT Version :10

• Sequence 1: NP_523676.1
• Gene: Pfk / 36060
• FlyBaseID: FBgn0003071
• Length: 950
• Species: Drosophila melanogaster
• Sequence 2: XP_006520664.1
• Gene: Pfkm / 18642
• MGIID: 97548
• Length: 850
• Species: Mus musculus
• Alignment Length: 750
• Identity: 460/750 - (61%)
• Similarity: 589/750 - (78%)
• Gaps: 10/750 - (1%)

  Fly   180 KGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSIIHRG 244
            |.:||.|||||:|||||||||.||:.|:.|.:|:|:.|||||:||||:.|:||.|.|||.::..|
Mouse    86 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLG 150

  Fly   245 GTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKNKTI 309
            ||:||||||:|||||:|||:||:||::||||||.|||||||||||:.||.|||.||::|.|:..|
Mouse   151 GTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKI 215

  Fly   310 TTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEVMGR 374
            |.|:..|.:.|:||||||||||||||||||||||:|||||:|.:|||::||.||||||::|||||
Mouse   216 TAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGR 280

  Fly   375 HCGYLALVGGLACEADFIFIPEMPPKVDWPDRLCSQLAQERSAGQRLNIVIVAEGAMDREGHPIT 439
            ||||||||..|:|.||::||||.||..||.:.||.:|::.|:.|.||||:||||||:|:.|.|||
Mouse   281 HCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPIT 345

  Fly   440 AEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVISLDG 504
            :||:|.::.:||.:|.|:||||||||||.||||||||..|||.||.:||:|.|.|:...|:||.|
Mouse   346 SEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSG 410

  Fly   505 NQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKPPKENFDADGKGI 569
            |||||:||||||:.|:.|.|||.|||:.:|:|||||||..|.|.||:|..::||.      .||
Mouse   411 NQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPV------SKG- 468

  Fly   570 EG-YRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGWVGQ 633
             | :.:|||::||||.||||||||.||..:.:|:.|..::||.|||..|.:.|.|||.|.||.||
Mouse   469 -GLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQ 532

  Fly   634 GGAYLGTKRTLPEGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIVVIPS 698
            ||:.||||||||:...::|:|.:.:|.||||:||||||:|....::.:.|..:.:.|||.||||:
Mouse   533 GGSKLGTKRTLPKKNLEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPA 597

  Fly   699 TISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAGGADA 763
            |:||||||::||:|.||.||.|...||||:|||.|||||||:|||||||||||||:||||.||||
Mouse   598 TVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADA 662

  Fly   764 AYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFTCRMN 828
            |||:||.|:|:|||.:|.|:..||...|.|||:|||||.:|||:||||:.||||||||:|..|.|
Mouse   663 AYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKN 727

  Fly   829 ILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQYRFS 893
            :||||||||||||||||..|||.||.::|::.:||.:. .||.:...:||:..:||:..|...|.
Mouse   728 VLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESY-RNGRIFANTPDSGCVLGMRKRALVFQ 791

  Fly   894 PLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHD 928
            |:.:|..:|:|:.||||:||||:|||:|:||||::
Mouse   792 PVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYE 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_523676.1	6PF1K_euk	180..929	CDD:274152	460/749 (61%)
Pfkm	XP_006520664.1	Eukaryotic_PFK	83..844	CDD:238389	460/749 (61%)