DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pfk and pfk-1.1

DIOPT Version :9

Sequence 1:	NP_001246234.1	Gene:	Pfk / 36060	FlyBaseID:	FBgn0003071	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_741738.1	Gene:	pfk-1.1 / 180583	WormBaseID:	WBGene00022199	Length:	814	Species:	Caenorhabditis elegans

Alignment Length:	769	Identity:	465/769 - (60%)
Similarity:	590/769 - (76%)	Gaps:	6/769 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 FKDKGLAVFTSGGDSQGMNAAVRACVRMAIYLGCKVYFIREGYQGMVDGGDCIQEANWASVSSII 241
            ||.:.||::||||||||||:|||:..|||||.|||||.|.|||:||::|||.|:||.|.:||.||
Worm    43 FKGRTLAIYTSGGDSQGMNSAVRSITRMAIYCGCKVYLIYEGYEGMIEGGDFIKEATWNTVSDII 107

  Fly   242 HRGGTIIGSARCQDFRERQGRLKAANNLIQRGITNLVVIGGDGSLTGANLFRQEWSSLLDELVKN 306
            .:|||||||||..:||.|:||||||.|||.|||..||.|||||||||||.||.||:.|:.|||||
Worm   108 QQGGTIIGSARSSEFRTREGRLKAATNLINRGIGRLVCIGGDGSLTGANTFRLEWTDLVQELVKN 172

  Fly   307 KTITTEQQEKFNVLHIVGLVGSIDNDFCGTDMTIGTDTALHRIIEAIDAISSTAYSHQRTFIMEV 371
            :.:|....:|...:.||||||||||||||||||||||:||.|||.:|||:.:||.||||.|::||
Worm   173 QRVTAAAAKKIPYIQIVGLVGSIDNDFCGTDMTIGTDSALQRIISSIDAVVATAQSHQRAFVIEV 237

  Fly   372 MGRHCGYLSVVAGIISEADYVFLPESPPQADWPDRLVLKLEQERSAGQRLNIVIVAEGAMDREGH 436
            ||||||||::||.:.||||:.|:||.|...:|.|.|..||.|.||.||||||:||||||:||:|.
Worm   238 MGRHCGYLALVAALASEADFCFIPEWPAPENWRDVLCDKLSQMRSEGQRLNIIIVAEGAIDRDGK 302

  Fly   437 PITAEDVKKVIDERLKHDARITVLGHVQRGGNPSAFDRILACRMGAEATLALMEATKDSVPVVIS 501
            .|||||||..:.|:||:|.|:|:||||||||.||||||:|.|||||||..||||.|::|.|.|||
Worm   303 AITAEDVKTAVKEKLKYDTRVTILGHVQRGGAPSAFDRLLGCRMGAEAVFALMEMTEESEPCVIS 367

  Fly   502 LDGNQAVRVPLMECVERTQAVAKAMAEKRWADAVKLRGRSFERNLETYKMLTRLKP-PKENFDAD 565
            :|||..|||||::||||||.|.||||:|.|..||.||||||:|||||||:||:::. .|:|....
Worm   368 IDGNVMVRVPLLKCVERTQMVQKAMADKDWTTAVMLRGRSFQRNLETYKLLTKMRTVEKDNLSEG 432

  Fly   566 GKGIEGYRLAVMHIGAPACGMNAAVRSFVRNAIYRGDVVYGINDGVEGLIAGNVRELGWSDVSGW 630
            .|    :.:||:::||||.||||||||:||.|:|....||||.|..|||..|:.::..||||:.|
Worm   433 HK----FNVAVINVGAPAGGMNAAVRSYVRMALYHQCTVYGIEDSFEGLANGSFKQFKWSDVTNW 493

  Fly   631 VGQGGAYLGTKRTLP-EGKFKEIAARLKEFKIQGLLIIGGFESYHAAGQIADQRDNYPQFCIPIV 694
            ...||::|||:::|| |....::||:||:..||.||::||||:||:...:|:.|:.||:||||:.
Worm   494 AMNGGSFLGTQKSLPTEKTMPQLAAQLKKHNIQALLLVGGFEAYHSTIILAENREKYPEFCIPMC 558

  Fly   695 VIPSTISNNVPGTEFSLGCDTGLNEITEICDRIRQSAQGTKRRVFVIETMGGYCGYLATLAGLAG 759
            |||.|||||||||..|||.||.:|||.::.|:|:|||.|||||||::|||||||||||||:.|:.
Worm   559 VIPCTISNNVPGTMVSLGSDTAINEICQMIDKIKQSATGTKRRVFIVETMGGYCGYLATLSALSS 623

  Fly   760 GADAAYIYEEKFSIKDLQQDVYHMASKMAEGVSRGLILRNEKASENYSTDFIYRLYSEEGKGLFT 824
            |||.|||:||.|:::||..||..:.|||..|..|.|::|||.|.:|.:|||:..|:..|||..||
Worm   624 GADNAYIFEEPFTVQDLSDDVDVILSKMEVGAKRYLVVRNEWADKNLTTDFVQNLFDSEGKKNFT 688

  Fly   825 CRMNILGHMQQGGSPTPFDRNMGTKMAAKCVDWLAAQIKANIDANGVVNCKSPDTATLLGIVSRQ 889
            .|:|:|||:||||||||||||||||:||:.:::|..|:|.|:.|:..|..||..||||||:..|:
Worm   689 TRVNVLGHVQQGGSPTPFDRNMGTKLAARALEFLLIQLKENLTADNKVIAKSAHTATLLGLKGRK 753

  Fly   890 YRFSPLVDLIAETNFDQRIPKKQWWLRLRPLLRILAKHDSAYEEEGMYITVEEE 943
            ..|:|:.||..||:|:.|:|.:|||:.||||||:||:|.|..|...:..:||||
Worm   754 VVFTPVQDLKKETDFEHRLPSEQWWMALRPLLRVLARHRSTVESSAILESVEEE 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pfk	NP_001246234.1	PFK	178..914	CDD:294137	447/737 (61%)
Pfk	NP_001246234.1	6PF1K_euk	180..929	CDD:274152	457/750 (61%)
pfk-1.1	NP_741738.1	PFK	44..792	CDD:294137	457/751 (61%)
pfk-1.1	NP_741738.1	6PF1K_euk	46..793	CDD:274152	457/750 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157877
Domainoid	1	1.000	430	1.000	Domainoid score	I298
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20101
Inparanoid	1	1.050	948	1.000	Inparanoid score	I166
Isobase	1	0.950	-	0	Normalized mean entropy	S685
OMA	1	1.010	-	-		QHG63571
OrthoDB	1	1.010	-	-		D172878at2759
OrthoFinder	1	1.000	-	-		FOG0000489
OrthoInspector	1	1.000	-	-		oto18889
orthoMCL	1	0.900	-	-		OOG6_100319
Panther	1	1.100	-	-	LDO	PTHR13697
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2168
SonicParanoid	1	1.000	-	-		X474
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890