DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 14-3-3zeta and BMH2

DIOPT Version :9

Sequence 1:	NP_001014515.1	Gene:	14-3-3zeta / 36059	FlyBaseID:	FBgn0004907	Length:	248	Species:	Drosophila melanogaster
Sequence 2:	NP_010384.3	Gene:	BMH2 / 851676	SGDID:	S000002506	Length:	273	Species:	Saccharomyces cerevisiae

Alignment Length:	244	Identity:	156/244 - (63%)
Similarity:	193/244 - (79%)	Gaps:	5/244 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KEELVQKAKLAEQSERYDDMAQAMKSVTETGVELSNEERNLLSVAYKNVVGARRSSWRVISSIEQ 70
            :|:.|..||||||:|||::|.:.||:|..:|.|||.|||||||||||||:||||:|||::|||||
Yeast     5 REDSVYLAKLAEQAERYEEMVENMKAVASSGQELSVEERNLLSVAYKNVIGARRASWRIVSSIEQ 69

  Fly    71 KTEASARKQ---QLAREYRERVEKELREICYEVLGLLDKYLIPKASNPESKVFYLKMKGDYYRYL 132
            |.|:..:.:   :|.|.||.::|.||.:|..::|.:||.:|||.|:..||||||.||||||:|||
Yeast    70 KEESKEKSEHQVELIRSYRSKIETELTKISDDILSVLDSHLIPSATTGESKVFYYKMKGDYHRYL 134

  Fly   133 AEVATGDARNTVVDDSQTAYQDAFDISKGKMQPTHPIRLGLALNFSVFYYEILNSPDKACQLAKQ 197
            ||.::||||....:.|..||:.|.:|:..::.||||||||||||||||||||.|||||||.||||
Yeast   135 AEFSSGDAREKATNSSLEAYKTASEIATTELPPTHPIRLGLALNFSVFYYEIQNSPDKACHLAKQ 199

  Fly   198 AFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSD--TQGDEAEPQE 244
            ||||||||||||:|:||||||||||||||||||||||  ..|.|.:.|:
Yeast   200 AFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDISESGQEDQQQQ 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
14-3-3zeta	NP_001014515.1	14-3-3	5..234	CDD:413191	151/230 (66%)
BMH2	NP_010384.3	BMH1	1..273	CDD:227373	156/244 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5040
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S35
OMA	1	1.010	-	-		QHG53683
OrthoFinder	1	1.000	-	-		FOG0000128
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100283
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1059
SonicParanoid	1	1.000	-	-		X206
TreeFam	0	0.000	Not matched by this tool.
	9	8.630