DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Jra and Atf2

DIOPT Version :9

Sequence 1:	NP_001260844.1	Gene:	Jra / 36057	FlyBaseID:	FBgn0001291	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_112280.1	Gene:	Atf2 / 81647	RGDID:	621862	Length:	487	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	83/404 - (20%)
Similarity:	144/404 - (35%)	Gaps:	102/404 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TAIQIIPKTEPVGEEGPMSLDFQSPNLNTSTP-NPNKRPGSLDLNS--KSAKNKRIFAPLVINSP 83
            |..|..|...|   |...:.:.:.|...|:.| :...||.||.:.:  .::.:..:.....:.||
  Rat   113 TTHQDSPLPHP---ESTTNDEKEIPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSP 174

  Fly    84 DLSSKTVNTPDLEKILLSNNLMQTPQPGKVFPTKAGPVTVEQLDFGRGFEEALHNLHTNSQAF-- 146
            ..|:.....|       |:|....|.||. ||      .:..|..|:....|:....|:|...
  Rat   175 TSSTVITQAP-------SSNRPIVPVPGP-FP------LLLHLPNGQTMPVAIPASITSSNVHVP 225

  Fly   147 --------------------PSANSAANSAANNTTAAAMTAVNNGISGGTFTYTNMTEGFSVIK- 190
                                ||:.....|.|.....||:|..:..::.|.   |....|..:::
  Rat   226 AAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGD---TVKGHGSGLVRA 287

  Fly   191 ----------DEPVNQASSPTVNPIDMEAQEKIKLERKR---------------QRNRVAASKCR 230
                      .:|....:....:|.....|.:....|:|               :|||.|||:||
  Rat   288 QSEESRPQSLQQPATSTTETPASPAHTTPQTQNTSGRRRRAANEDPDEKRRKFLERNRAAASRCR 352

  Fly   231 KRKLERISKLEDRVKVLKGENVDLASIVKNLKDHVAQLKQQVMEHIAAGCTVPPNSTDQXHLELS 295
            :::...:..||.:.:.|...|..|.|.|..|::.||||||.::.|  ..|.|       ..::..
  Rat   353 QKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAH--KDCPV-------TAMQKK 408

  Fly   296 AGEN--DEEDVALETETPSNPEDPEQPMPLEFFSSASTGALELEGSASQDISLTNSELLEEESDN 358
            :|.:  |::|.:.:...||:|.               |.|::     ...:|.:|......:::.
  Rat   409 SGYHTADKDDSSEDLSVPSSPH---------------TEAIQ-----HSSVSTSNGVSSTSKTEA 453

  Fly   359 EQPLVLYILADDAT 372
            ....||..:||.:|
  Rat   454 GATSVLTQMADQST 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jra	NP_001260844.1	Jun	<76..>144	CDD:281890	15/67 (22%)
		bZIP_Jun	214..274	CDD:269844	24/74 (32%)
		coiled coil	215..266	CDD:269844	18/65 (28%)
Atf2	NP_112280.1	C2H2 Zn finger	9..31	CDD:275370
		GCN4_cent	47..84	CDD:213399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	107..130		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..355		23/116 (20%)
		Essential for its histone acetyltransferase activity. /evidence=ECO:0000250	278..281		0/2 (0%)
		bZIP_ATF2	336..396	CDD:269835	22/59 (37%)
		coiled coil	336..396	CDD:269835	22/59 (37%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	336..356		8/19 (42%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	362..390		10/27 (37%)
		Nuclear export signal. /evidence=ECO:0000250	387..396		6/8 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..487		15/81 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910