DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jra and JUND

DIOPT Version :9

Sequence 1:	NP_001260844.1	Gene:	Jra / 36057	FlyBaseID:	FBgn0001291	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_005345.3	Gene:	JUND / 3727	HGNCID:	6206	Length:	347	Species:	Homo sapiens

Alignment Length:	346	Identity:	110/346 - (31%)
Similarity:	161/346 - (46%)	Gaps:	68/346 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKTPVSAAANLSIQNAGSSG-----ATAIQIIPKTEPVGEEGPM----SLDFQSPNLNTSTPNPN 56
            |:||......||....|:||     |:..::.|...|....|.|    :|.........:...|.
Human     1 METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSEQVAAALKPA 65

  Fly    57 KRPGSLDLNSKSAKNKRIFAPL--VINSPDLSSKTVNTPDLEKILLSNNLMQTPQPGK---VFPT 116
            ..|....|.:..|.:.   ||.  ::.||||....:.:|:||::::.:|.:.|..|..   ::|.
Human    66 AAPPPTPLRADGAPSA---APPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTSSQFLYPK 127

  Fly   117 KAGPVTVEQLDFGRGFEEALHNLHTNSQAFPSANSAANSAANNTTAAAMT--------------- 166
            .|..   |:.:|..||.:||.:||..:|....|.:||.:||....:...|
Human   128 VAAS---EEQEFAEGFVKALEDLHKQNQLGAGAAAAAAAAAAGGPSGTATGSAPPGELAPAAAAP 189

  Fly   167 -----------AVNNGISGGTFTYTNMTE----------------GFSVIKDEP------VNQAS 198
                       |...|.:||..|.....|                ..:.:||||      .:...
Human   190 EAPVYANLSSYAGGAGGAGGAATVAFAAEPVPFPPPPPPGALGPPRLAALKDEPQTVPDVPSFGE 254

  Fly   199 SPTVNPIDMEAQEKIKLERKRQRNRVAASKCRKRKLERISKLEDRVKVLKGENVDLASIVKNLKD 263
            ||.::||||:.||:||.||||.|||:||||||||||||||:||::||.||.:|.:|||....|::
Human   255 SPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLRE 319

  Fly   264 HVAQLKQQVMEHIAAGCTVPP 284
            .||||||:|:.|:.:||.:.|
Human   320 QVAQLKQKVLSHVNSGCQLLP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jra	NP_001260844.1	Jun	<76..>144	CDD:281890	22/72 (31%)
		bZIP_Jun	214..274	CDD:269844	40/59 (68%)
		coiled coil	215..266	CDD:269844	32/50 (64%)
JUND	NP_005345.3	Jun	1..257	CDD:281890	58/261 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		11/41 (27%)
		Menin-binding motif (MBM). /evidence=ECO:0000269\|PubMed:22327296	27..39		2/11 (18%)
		MAP kinase docking motif, essential for its phosphorylation. /evidence=ECO:0000269\|PubMed:22327296	46..55		1/8 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..86		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..264		5/19 (26%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	268..295		22/26 (85%)
		bZIP_Jun	270..329	CDD:269844	39/58 (67%)
		coiled coil	271..322	CDD:269844	32/50 (64%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	296..324		13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149784
Domainoid	1	1.000	89	1.000	Domainoid score	I7846
eggNOG	1	0.900	-	-		E1_KOG0837
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4527
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1090460at2759
OrthoFinder	1	1.000	-	-		FOG0001331
OrthoInspector	1	1.000	-	-		otm41026
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11462
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4616
SonicParanoid	1	1.000	-	-		X1044
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890