DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jra and Atf7

DIOPT Version :9

Sequence 1:	NP_001260844.1	Gene:	Jra / 36057	FlyBaseID:	FBgn0001291	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001296995.1	Gene:	Atf7 / 223922	MGIID:	2443472	Length:	483	Species:	Mus musculus

Alignment Length:	433	Identity:	92/433 - (21%)
Similarity:	159/433 - (36%)	Gaps:	124/433 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QNAGSSGATAIQIIPKTE--PVGEEGPMSLDFQSPN--------------------LNTSTPNPN 56
            :..|::|...:. :|.|.  .:.||.|:.:|...|:                    :..|||.|.
Mouse    86 EKKGAAGPLDMS-LPSTPDIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTTKPVVISTPTPT 149

  Fly    57 -KRPGSLDLN------------------SKSAKNKRIFA-----PLVIN------SPDLSSKTVN 91
             .|||||.|:                  .....|::|.:     |||::      .|.|....|.
Mouse   150 IVRPGSLPLHLGYDPLHPTLPSPTSVITQAPPSNRQIGSPTGSLPLVMHLANGQTMPMLPGPPVQ 214

  Fly    92 TPDLEKILLSNNLMQTPQ-PGKVFPTKAGPVTVEQLDFGRGFEEALHNLHTNSQAFPSANSAANS 155
            .|.:  |.|:..:...|. ||...|    ||                   .||.:...:.....|
Mouse   215 MPSV--ISLARPVSMVPNIPGIPGP----PV-------------------NNSGSISPSGHPMPS 254

  Fly   156 AANNTTAAAMTAVNNGISGG---------TFTYTNMTEGFSVIKDEPVNQASSPTVNP------- 204
            .|.....|.:|...:.|:||         |.......:...:|:.......:.|.|:|
Mouse   255 EAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARPEQNQILIQHPDAPSPAQPQVSPAQPTPST 319

  Fly   205 -------IDMEAQEKIKLERKRQRNRVAASKCRKRKLERISKLEDRVKVLKGENVDLASIVKNLK 262
                   :|.:..|  :.:|..:|||.|||:||:::...:|.||.:.:.|..:|:.|::.|..|:
Mouse   320 GGRRRRTVDEDPDE--RRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLR 382

  Fly   263 DHVAQLKQQVMEHIAAGCTVPPNSTDQXHLELSAGENDEEDVALETETPSNPEDPE-QPMPLEFF 326
            :.||||||.::.|.....|.....| |.:|                |:|....:|. .|.|:...
Mouse   383 NEVAQLKQLLLAHKDCPVTALQKKT-QGYL----------------ESPKESSEPTGSPAPVIQH 430

  Fly   327 SSAS--TGALELEGSASQDISLTNSELLEEESDNEQPLVLYIL 367
            ||||  :..|.:..:|....:...:::..:.::...|:..:::
Mouse   431 SSASAPSNGLSVRSAAEAVATSVLTQMASQRTELSMPIQSHVI 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jra	NP_001260844.1	Jun	<76..>144	CDD:281890	16/79 (20%)
		bZIP_Jun	214..274	CDD:269844	23/59 (39%)
		coiled coil	215..266	CDD:269844	17/50 (34%)
Atf7	NP_001296995.1	Transactivation domain. /evidence=ECO:0000250	1..285		45/224 (20%)
		C2H2 Zn finger	9..31	CDD:275370
		GCN4_cent	47..84	CDD:213399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..140		9/54 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..337		5/39 (13%)
		bZIP_ATF2	334..394	CDD:269835	23/59 (39%)
		coiled coil	334..394	CDD:269835	23/59 (39%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	334..354		9/19 (47%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	360..388		9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910