DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jra and Jund

DIOPT Version :9

Sequence 1:	NP_001260844.1	Gene:	Jra / 36057	FlyBaseID:	FBgn0001291	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_034722.1	Gene:	Jund / 16478	MGIID:	96648	Length:	341	Species:	Mus musculus

Alignment Length:	348	Identity:	112/348 - (32%)
Similarity:	160/348 - (45%)	Gaps:	78/348 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKTPVSAAANLSIQNAGSS---GAT-------------AIQIIPKTEPVGEEGPMSLDFQSPNLN 49
            |:||......||...||:|   |||             |....|.|..:.::..::|........
Mouse     1 METPFYGEEALSGLAAGASSVAGATGAPGGGGFAPPGRAFPGAPPTSSMLKKDALTLSLAEQGAA 65

  Fly    50 TSTPNPNKRPGSLDLNSKSAKNKRIFAP-LVINSPDLSSKTVNTPDLEKILLSNNLMQTPQPGK- 112
            ...|.....|.:|..:.         || .::.||||....:.:|:||::::.:|.:.|..|..
Mouse    66 GLKPGSATAPSALRPDG---------APDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTST 121

  Fly   113 --VFPTKAGPVTVEQLDFGRGFEEALHNLHTNSQAFPSANSAANSAANNTTAAAMTAVNNGIS-- 173
              ::|..|..   |:.:|..||.:||.:||..||.  .|.:||.|.|....|.|..|...|.:
Mouse   122 QFLYPKVAAS---EEQEFAEGFVKALEDLHKQSQL--GAATAATSGAPAPPAPADLAATPGATET 181

  Fly   174 ----------------GGTFTYTNMTE--------------------GFSVIKDEP------VNQ 196
                            ||..|.....|                    ..:.:||||      .:.
Mouse   182 PVYANLSSFAGGAGPPGGAATVAFAAEPVPFPPPPGALGPPPPPHPPRLAALKDEPQTVPDVPSF 246

  Fly   197 ASSPTVNPIDMEAQEKIKLERKRQRNRVAASKCRKRKLERISKLEDRVKVLKGENVDLASIVKNL 261
            ..||.::||||:.||:||.||||.|||:||||||||||||||:||::||.||.:|.:|||....|
Mouse   247 GDSPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLL 311

  Fly   262 KDHVAQLKQQVMEHIAAGCTVPP 284
            ::.||||||:|:.|:.:||.:.|
Mouse   312 REQVAQLKQKVLSHVNSGCQLLP 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jra	NP_001260844.1	Jun	<76..>144	CDD:281890	22/71 (31%)
		bZIP_Jun	214..274	CDD:269844	40/59 (68%)
		coiled coil	215..266	CDD:269844	32/50 (64%)
Jund	NP_034722.1	Jun	1..251	CDD:309180	60/263 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..49		7/30 (23%)
		Menin-binding motif (MBM). /evidence=ECO:0000250\|UniProtKB:P17535	35..47		2/11 (18%)
		MAP kinase docking motif, essential for its phosphorylation. /evidence=ECO:0000250\|UniProtKB:P17535	51..60		1/8 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..85		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..176		8/20 (40%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	262..289		22/26 (85%)
		bZIP_Jun	264..323	CDD:269844	39/58 (67%)
		coiled coil	265..316	CDD:269844	32/50 (64%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	290..318		13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839838
Domainoid	1	1.000	89	1.000	Domainoid score	I7823
eggNOG	1	0.900	-	-		E1_KOG0837
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1090460at2759
OrthoFinder	1	1.000	-	-		FOG0001331
OrthoInspector	1	1.000	-	-		otm43096
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11462
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4616
SonicParanoid	1	1.000	-	-		X1044
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890