DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jra and Jun

DIOPT Version :9

Sequence 1:	NP_001260844.1	Gene:	Jra / 36057	FlyBaseID:	FBgn0001291	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_034721.1	Gene:	Jun / 16476	MGIID:	96646	Length:	334	Species:	Mus musculus

Alignment Length:	312	Identity:	102/312 - (32%)
Similarity:	147/312 - (47%)	Gaps:	80/312 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GEEGPMSLDFQSPNLNTSTPNPNKRPGSLDLNSKSAKNKRIFAPLVINSPDLSSKTVNTPDLEKI 98
            |...|..|. ||..||.:.|     .|||..:.: |||..:     :.|||:....:.:|:||::
Mouse    27 GYSNPKILK-QSMTLNLADP-----VGSLKPHLR-AKNSDL-----LTSPDVGLLKLASPELERL 79

  Fly    99 LL---SNNLMQTPQPGKVFPTKAGPVTVEQLDFGRGFEEALHNLHTNSQAFPSANSAANSAAN-N 159
            ::   :.::..||.|.:....|  .||.||..|..||..||..||:.: ..||..|||...:. .
Mouse    80 IIQSSNGHITTTPTPTQFLCPK--NVTDEQEGFAEGFVRALAELHSQN-TLPSVTSAAQPVSGAG 141

  Fly   160 TTAAAMTAVNNGISGGTFT---------YTNMTE------------------------------- 184
            ..|.|:.:|.....||.::         |.|::.
Mouse   142 MVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPSQPQQQQQ 206

  Fly   185 -----------------GFSVIKDEPVN----QASSPTVNPIDMEAQEKIKLERKRQRNRVAASK 228
                             ....:|:||..    ...:|.::|||||:||:||.||||.|||:||||
Mouse   207 PPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASK 271

  Fly   229 CRKRKLERISKLEDRVKVLKGENVDLASIVKNLKDHVAQLKQQVMEHIAAGC 280
            |||||||||::||::||.||.:|.:|||....|::.||||||:||.|:.:||
Mouse   272 CRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGC 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jra	NP_001260844.1	Jun	<76..>144	CDD:281890	21/70 (30%)
		bZIP_Jun	214..274	CDD:269844	39/59 (66%)
		coiled coil	215..266	CDD:269844	31/50 (62%)
Jun	NP_034721.1	Jun	5..244	CDD:309180	50/231 (22%)
		Interaction with PAGE4. /evidence=ECO:0000250\|UniProtKB:P05412	150..226		5/75 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..217		0/25 (0%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	255..282		22/26 (85%)
		bZIP_Jun	257..317	CDD:269844	39/59 (66%)
		coiled coil	258..309	CDD:269844	31/50 (62%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	283..311		13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839837
Domainoid	1	1.000	89	1.000	Domainoid score	I7823
eggNOG	1	0.900	-	-		E1_KOG0837
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001331
OrthoInspector	1	1.000	-	-		otm43096
orthoMCL	1	0.900	-	-		OOG6_106880
Panther	1	1.100	-	-	O	PTHR11462
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4616
SonicParanoid	1	1.000	-	-		X1044
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780