DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut4 and VBA1

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_013806.1	Gene:	VBA1 / 855113	SGDID:	S000004694	Length:	562	Species:	Saccharomyces cerevisiae

Alignment Length:	460	Identity:	94/460 - (20%)
Similarity:	173/460 - (37%)	Gaps:	91/460 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGAFCLGAVIGWSGPVENEVKNSNAYNFTPRQTEWGLVGSLMTLGAAFSCIPVGVLIGKI----G 75
            ||:|    :......:...:.|..|..|:....:..:..|.:....||.     .|.||:    |
Yeast    44 LGSF----LSSLDSTIVANIMNRVAEEFSESSKKQWIATSFLLTNTAFQ-----PLYGKLSDITG 99

  Fly    76 RKTTMLILLPPFFIGWLLILLASHIAMLLLGRFVVGFCGGAFCVTCPMYVTEIAQVQYRGTMGCF 140
            ||:.:|.....|.:|.||...|.::....:.|.:.|...|.......:.|::|...:.||....:
Yeast   100 RKSALLTAQFFFGLGCLLTCFARNVTEFSIARAICGIGAGGLNAISSIAVSDICTARERGVYQGY 164

  Fly   141 FQLLIVFGILYAFVVGG-FVKTFYFNIACAI-LPVIFF--VLMIFMPESPIFLAQKGKAEKAEKS 201
            ..::..||.|....:|| |::|..:.....| :|||..  ||.|......:|.....|.....|:
Yeast   165 ANIVFGFGQLLGAPLGGVFIETIGWRALFGIQVPVIMLCSVLAIKNINIKLFHVPPMKERYTLKN 229

  Fly   202 LKFLRGKDADVSGELKEMSAEGQKEKASVGKI--LCRRITLKGLFLSIGLMLFQQMTGINAIIFY 264
            |..:     |:.|.|..:        |::..:  ||.. .|..|:|::       .|..:.|:|.
Yeast   230 LSRI-----DIFGSLSLV--------ATISGVLFLCSS-QLNKLYLAL-------FTIGSFIVFI 273

  Fly   265 STFIFETAGSTLEPRISTIIVGIVQAIATIISILVIEKVGR-----KILLLVSACMMGISTLI-- 322
            ....:......|...:.|....:..|:..|.|.:|..::.|     ::|..:|....|:..:.
Yeast   274 LVERYYATEKILPFELLTRSFCLSSAVTVISSFVVFGEIFRSPIYLQLLQNISVTKTGLFLIFPS 338

  Fly   323 MALYFGMLMKSGVGWLAL-----IAVCVFIIGFS------LGFGPVPWLMMAEL--------FAE 368
            :::..|.|:   .||:..     :|.|.:.|.|.      ||.| :.:.:::.|        ..|
Yeast   339 ISVAVGSLV---TGWVLRNTKINLAHCAYQIIFGGMIMQLLGLG-LGYFLLSHLNPDYTIYDMLE 399

  Fly   369 DVKALAGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFA---VAAFVFILFLIPETKGK 430
            .:...:.||.....:.||.::                  :.||:|   ||..|.|:|.:.:::..
Yeast   400 SITFRSNSIWWKLIYVFASVL------------------VSFGYACLLVATLVSIVFTVEKSQQG 446

  Fly   431 TLNEI 435
            |:..:
Yeast   447 TMTGV 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	94/460 (20%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	87/415 (21%)
VBA1	NP_013806.1	MFS_Azr1_MDR_like	42..469	CDD:341045	94/460 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900