DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sut4 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_445946.2	Gene:	Slc2a8 / 85256	RGDID:	620611	Length:	478	Species:	Rattus norvegicus

Alignment Length:	455	Identity:	150/455 - (32%)
Similarity:	249/455 - (54%)	Gaps:	32/455 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FIVGFIGALGAFCLGAVIGWSGPVENEVKNS--NAYNFTPRQTEWGLVGSLMTLGAAFSCIPVGV 69
            |:..|..|||....|..:|:|.|....::.:  .|.........|  .|:::|||||...:..|.
  Rat    27 FLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASW--FGAVVTLGAAAGGVLGGW 89

  Fly    70 LIGKIGRKTTMLILLPPFFIGWLLILLASHIAMLLLGRFVVGFCGGAFCVTCPMYVTEIAQVQYR 134
            |:.:.|||.::|:...||..|:.:|..|..:.|||.||.:.|...|...:..|:|::|||....|
  Rat    90 LLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVR 154

  Fly   135 GTMGCFFQLLIVFGILYAFVVGGFVKTFYFNIACAILPVIFFVLMIFMPESPIFLAQKGKAEKAE 199
            |.:|...||::|.|||.|:|.|..::..:..:...:.|.:..:||.:|||:|.||..:.:.::|.
  Rat   155 GLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAM 219

  Fly   200 KSLKFLRGKDADVSGELKEMSAEGQKEKASVGKILCRRITLKGLFLSIGLMLFQQMTGINAIIFY 264
            .:|:||.|  ::...|...:.||.|..:.:   :|.|....|.|.:.|.||:|||::|:|||:||
  Rat   220 AALRFLWG--SEEGWEEPPVGAEHQGFQLA---MLRRPGVHKPLIIGICLMVFQQLSGVNAIMFY 279

  Fly   265 STFIFETAGSTLEPRISTIIVGIVQAIATIISILVIEKVGRKILLLVSACMMGISTLIMALYF-- 327
            :..|||.| ...:..::::.|||:|.:.|.::.|::::.|||:||.:|..:|..|......||
  Rat   280 ANTIFEEA-KFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALSGVIMVFSMSAFGTYFKL 343

  Fly   328 -----------GML---------MKSGVGWLALIAVCVFIIGFSLGFGPVPWLMMAELFAEDVKA 372
                       |:|         :..|:.|||:.::|:||.||::|:||:|||:|:|:|...:|.
  Rat   344 TQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHIKG 408

  Fly   373 LAGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFAVAAFVFILFLIPETKGKTLNEIQA 437
            :|..:...|||..||:||..|..:.:|:.....|.:...|.:.:.:|.|..:|||||:||.:|.|
  Rat   409 VATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCILSVLFTLTFVPETKGRTLEQITA 473

Fly 438 437
Rat 474 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	147/450 (33%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	131/398 (33%)
Slc2a8	NP_445946.2	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:10671487	12..13
		MFS	27..470	CDD:421695	148/450 (33%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337687
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		otm45904
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.760