DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut4 and HXT3

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_010632.1	Gene:	HXT3 / 851946	SGDID:	S000002753	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	474	Identity:	121/474 - (25%)
Similarity:	219/474 - (46%)	Gaps:	62/474 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALGAFCLGAVIGW-SGPVENEVKNSN------------AYNFTPRQTEWGLVGSLMTLGAAFSCI 65
            |.|.|    |.|| :|.:...|..::            :|..:..:|  ||:.|:..:|.|..
Yeast    70 AFGGF----VFGWDTGTISGFVAQTDFLRRFGMKHKDGSYYLSKVRT--GLIVSIFNIGCAIG-- 126

  Fly    66 PVGVLIGKI----GRKTTMLILLPPFFIGWLLILLAS--HIAMLLLGRFVVGFCGGAFCVTCPMY 124
              |:::.|:    |||..:::::..:.|| ::|.:||  ......:||.:.|...|...|..||.
Yeast   127 --GIILAKLGDMYGRKMGLIVVVVIYIIG-IIIQIASINKWYQYFIGRIISGLGVGGIAVLSPML 188

  Fly   125 VTEIAQVQYRGTMGCFFQLLIVFGILYAFVVGGFVKTFYFNIACAI-LPVIF----FVL--MIFM 182
            ::|:|..:.|||:...:||:|..||...:......|.:..::...: |.:.|    |::  |.|:
Yeast   189 ISEVAPKEMRGTLVSCYQLMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGGMTFV 253

  Fly   183 PESPIFLAQKGKAEKAEKSLK----------FLRGKDADVSGELKEMSAEGQKEKASVGKILCRR 237
            ||||.:|.:.|:.::|..||.          |::.:...:...::|..|.|   .||.|::...:
Yeast   254 PESPRYLVEAGQIDEARASLSKVNKVAPDHPFIQQELEVIEASVEEARAAG---SASWGELFTGK 315

  Fly   238 ITL-KGLFLSIGLMLFQQMTGINAIIFYSTFIFETAGSTLEPRISTIIVGIVQAIATIISILVIE 301
            ..: |...:.|.:...||:||.|...:|.|.:|...|.: :...::|:.|:|...:|..|:..::
Yeast   316 PAMFKRTMMGIMIQSLQQLTGDNYFFYYGTTVFNAVGMS-DSFETSIVFGVVNFFSTCCSLYTVD 379

  Fly   302 KVGRKILLLVSACMMGISTLIMALY---------FGMLMKSGVGWLALIAVCVFIIGFSLGFGPV 357
            :.||:..||..|..|....::.|..         .|.....|.|...::..|.:|..|:..:.|:
Yeast   380 RFGRRNCLLYGAIGMVCCYVVYASVGVTRLWPNGEGNGSSKGAGNCMIVFACFYIFCFATTWAPI 444

  Fly   358 PWLMMAELFAEDVKALAGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFAVAAFVFILF 422
            .:::::|.|...||:.|.|||...||.:.|::....|.:...|.....: :|.|..|.|:.::.|
Yeast   445 AYVVISETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAINFYYGY-VFMGCMVFAYFYVFF 508

  Fly   423 LIPETKGKTLNEIQAKMGE 441
            .:|||||.||.|:.....|
Yeast   509 FVPETKGLTLEEVNDMYAE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	120/467 (26%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	103/409 (25%)
HXT3	NP_010632.1	Sugar_tr	65..525	CDD:395036	120/470 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342316
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	7	6.690