DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut4 and HXT6

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_010630.1	Gene:	HXT6 / 851944	SGDID:	S000002751	Length:	570	Species:	Saccharomyces cerevisiae

Alignment Length:	475	Identity:	131/475 - (27%)
Similarity:	227/475 - (47%)	Gaps:	64/475 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALGAFCLGAVIGW-----SGPVENE-------VKNSNAYNFTPRQTEWGLVGSLMTLGAAFSCIP 66
            |.|.|    |.||     ||.:...       :|:.:..|:..: ...||:.|:..:|.|..
Yeast    73 AFGGF----VFGWDTGTISGFINQTDFIRRFGMKHKDGTNYLSK-VRTGLIVSIFNIGCAIG--- 129

  Fly    67 VGVLIGKI----GRKTTMLILLPPFFIGWLLILLAS--HIAMLLLGRFVVGFCGGAFCVTCPMYV 125
             |:::.|:    |||..:::::..:.|| ::|.:||  ......:||.:.|...|...|..||.:
Yeast   130 -GIILSKLGDMYGRKVGLIVVVVIYIIG-IIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLI 192

  Fly   126 TEIAQVQYRGTMGCFFQLLIVFGILYAFVVGGFVKTFYFNIACAI-LPVIF----FVL--MIFMP 183
            :|::....|||:...:||:|..||...:......|.:..::...: |.:.|    |::  |.|:|
Yeast   193 SEVSPKHLRGTLVSCYQLMITAGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGGMTFVP 257

  Fly   184 ESPIFLAQKGKAEKAEKSLKF---LRGKDADVSGELKEMSAEGQKEK----ASVGKILCRRI-TL 240
            |||.:||:.||.|:|::|:..   :...|..|..|::.:.|..:.||    ||.|::...:. .|
Yeast   258 ESPRYLAEVGKIEEAKRSIAVSNKVAVDDPSVLAEVEAVLAGVEAEKLAGNASWGELFSSKTKVL 322

  Fly   241 KGLFLSIGLMLFQQMTGINAIIFYSTFIFETAG--STLEPRISTIIVGIVQAIATIISILVIEKV 303
            :.|.:...:...||:||.|...:|.|.||:..|  .:.|   ::|::|||...:|.:.|.|:|:.
Yeast   323 QRLIMGAMIQSLQQLTGDNYFFYYGTTIFKAVGLSDSFE---TSIVLGIVNFASTFVGIYVVERY 384

  Fly   304 GRKILLLVSACMMGISTLIMALYFGMLM------------KSGVGWLALIAVCVFIIGFSLGFGP 356
            ||:..||..|..|   |..|.:|..:.:            ..|.|...::..|.:|..|:..:.|
Yeast   385 GRRTCLLWGAASM---TACMVVYASVGVTRLWPNGQDQPSSKGAGNCMIVFACFYIFCFATTWAP 446

  Fly   357 VPWLMMAELFAEDVKALAGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFAVAAFVFIL 421
            :|:::::|.|...||:.|.|||...||.:.|::....|.:...|.....: :|.|..|..|.::|
Yeast   447 IPYVVVSETFPLRVKSKAMSIATAANWLWGFLIGFFTPFITGAINFYYGY-VFMGCLVFMFFYVL 510

  Fly   422 FLIPETKGKTLNEIQAKMGE 441
            .::|||||.||.|:.....|
Yeast   511 LVVPETKGLTLEEVNTMWEE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	130/468 (28%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	112/411 (27%)
HXT6	NP_010630.1	Sugar_tr	68..528	CDD:278511	130/471 (28%)
HXT6	NP_010630.1	MFS	69..514	CDD:119392	122/457 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342324
Domainoid	1	1.000	165	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I1037
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	8	7.690