DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sut4 and SLC2A4

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens

Alignment Length:	464	Identity:	154/464 - (33%)
Similarity:	241/464 - (51%)	Gaps:	32/464 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TATQFIVGFIGALGAFCLGAVIGWSGPVENEVKNSNAYNFTPRQ--------------TEWGLVG 53
            |.|..:..|...||:...|..||.....:..::.|....:..||              |.|.|..
Human    21 TGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSV 85

  Fly    54 SLMTLGAAFSCIPVGVLIGKIGRKTTMLILLPPFFIGWLLILLASHIA---MLLLGRFVVGFCGG 115
            ::.::|...|...:|::...:|||..||:......:|..|:.||:..|   ||:||||::|...|
Human    86 AIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSG 150

  Fly   116 AFCVTCPMYVTEIAQVQYRGTMGCFFQLLIVFGILYAFVVG-----GFVKTFYFNIACAILPVIF 175
            ......||||.|||....||.:|...||.||.|||.|.|:|     |....:...:...:||.:.
Human   151 LTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALL 215

  Fly   176 -FVLMIFMPESPIFLAQKGKAE-KAEKSLKFLRGKDADVSGELKEMSAEGQK----EKASVGKIL 234
             .||:.|.||||.:|......| .|.||||.|.|. |||||.|.|:..|.:|    ...|:.::|
Human   216 QLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGW-ADVSGVLAELKDEKRKLERERPLSLLQLL 279

  Fly   235 CRRITLKGLFLSIGLMLFQQMTGINAIIFYSTFIFETAGSTLEPRISTIIVGIVQAIATIISILV 299
            ..|...:.|.:::.|.|.||::||||:.:|||.|||||| ..:|..:||..|:|..:.|::|:|:
Human   280 GSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAG-VGQPAYATIGAGVVNTVFTLVSVLL 343

  Fly   300 IEKVGRKIL-LLVSACMMGISTLIMALYFGMLMKSGVGWLALIAVCVFIIGFSLGFGPVPWLMMA 363
            :|:.||:.| ||..|.|.|.:.|:......:.....:.:::::|:..|:..|.:|.||:||.::|
Human   344 VERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVA 408

  Fly   364 ELFAEDVKALAGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFAVAAFVFILFLIPETK 428
            |||::..:..|.::||.:||...||:.:.|..:.:.:|... |.:|....:..|:|....:|||:
Human   409 ELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYV-FLLFAVLLLGFFIFTFLRVPETR 472

  Fly   429 GKTLNEIQA 437
            |:|.::|.|
Human   473 GRTFDQISA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	150/455 (33%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	136/391 (35%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	152/458 (33%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143921
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740