DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut4 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_062361.1	Gene:	Slc2a8 / 56017	MGIID:	1860103	Length:	477	Species:	Mus musculus

Alignment Length:	454	Identity:	149/454 - (32%)
Similarity:	250/454 - (55%)	Gaps:	31/454 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FIVGFIGALGAFCLGAVIGWSGPVENEVKNS--NAYNFTPRQTEWGLVGSLMTLGAAFSCIPVGV 69
            |:..|..|||....|..:|:|.|....::.:  .|.........|  .|:::|||||...|..|.
Mouse    27 FLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASW--FGAVVTLGAAAGGILGGW 89

  Fly    70 LIGKIGRKTTMLILLPPFFIGWLLILLASHIAMLLLGRFVVGFCGGAFCVTCPMYVTEIAQVQYR 134
            |:.:.|||.::|:...||..|:.:|..|..:.|||.||.:.|...|...:..|:|::|||....|
Mouse    90 LLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVR 154

  Fly   135 GTMGCFFQLLIVFGILYAFVVGGFVKTFYFNIACAILPVIFFVLMIFMPESPIFLAQKGKAEKAE 199
            |.:|...||::|.|||.|:|.|..::..:..:...:.|.:..:||.:|||:|.||..:.:.::|.
Mouse   155 GLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAM 219

  Fly   200 KSLKFLRGKDADVSGELKEMSAEGQKEKASVGKILCRRITLKGLFLSIGLMLFQQMTGINAIIFY 264
            .:|:||.|  ::...|...:.||.|..:.:   :|.|....|.|.:.|.||:|||::|:|||:||
Mouse   220 AALRFLWG--SEEGWEEPPVGAEHQGFQLA---LLRRPGIYKPLIIGISLMVFQQLSGVNAIMFY 279

  Fly   265 STFIFETAGSTLEPRISTIIVGIVQAIATIISILVIEKVGRKILLLVSACMMGISTLIMALYF-- 327
            :..|||.| ...:..::::.|||:|.:.|.::.|::::.||::||.:|..:|..|......||
Mouse   280 ANSIFEEA-KFKDSSLASVTVGIIQVLFTAVAALIMDRAGRRLLLALSGVIMVFSMSAFGTYFKL 343

  Fly   328 -----------GML--------MKSGVGWLALIAVCVFIIGFSLGFGPVPWLMMAELFAEDVKAL 373
                       |::        ::.|:.|||:.::|:||.||::|:||:|||:|:|:|...||.:
Mouse   344 TQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGV 408

  Fly   374 AGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFAVAAFVFILFLIPETKGKTLNEIQA 437
            |..|...|||..||:||..|..:.:::.....|.:...|...:.:|.|.::|||||:||.::.|
Mouse   409 ATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWLTAAFCALSVLFTLTVVPETKGRTLEQVTA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	147/449 (33%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	131/397 (33%)
Slc2a8	NP_062361.1	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:16723738	12..13
		Sugar_tr	29..474	CDD:278511	148/452 (33%)
		MFS	31..459	CDD:119392	140/435 (32%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D524131at33208
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8886
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760