DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sut4 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_001100921.1	Gene:	Slc2a12 / 308028	RGDID:	1310175	Length:	621	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	126/535 - (23%)
Similarity:	235/535 - (43%)	Gaps:	109/535 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FIVGFIGALGAFCLGAVIGWSGPVENEVKNSNAYNFTPRQTEWGLVGSLMTLGAAFSCIPVGVLI 71
            |:.....|:....:|..:|.......:::...|  .|..:.|  :|.|.:.:||..:.:..||||
  Rat    45 FLTSVTAAISGLLVGYELGLISGALLQIRTLLA--LTCHEQE--MVVSSLLIGAFLASLTGGVLI 105

  Fly    72 GKIGRKTTMLILLPPFFIGWLLILLASHIAMLLLGRFVVGFCGGAFCVTCPMYVTEIAQVQYRGT 136
            .:.||:.|:::......:|.|:::|:....:|:.||..:|.......:...:|:.|||....||.
  Rat   106 DRYGRRLTIILSSCLLGLGSLVLILSLSYTLLITGRVAIGVSISLSSIATCVYIAEIAPQHRRGL 170

  Fly   137 MGCFFQLLIVFGILYAF--------VVGGFVKTFYFNIACAILPVIFFVLMIFMPESPIFLAQKG 193
            :....:|:||.|||:|:        :..|:...|...|...:|..|   .|.|:|.||.||..||
  Rat   171 LVSLNELMIVTGILFAYISNYAFANISNGWKYMFGLVIPLGVLQAI---AMYFLPPSPRFLVMKG 232

  Fly   194 KAEKAEKSLKFLRGKDADVSGELKEMSAEGQKE-KASVGKILCRRITLK-GLFLSIGLMLFQQMT 256
            :.|.|.|.|:.|| ..:|.:.||..:.:..:.| :.|...:...:..:: .:.:.:.|:.|.|.|
  Rat   233 QEEAAGKVLRKLR-VISDTAEELTLIKSSLKDEYQYSFWDLFRSKDNMRTRILIGLTLVFFVQTT 296

  Fly   257 GINAIIFYSTFIFETAG--STLEPRISTIIVGIVQAIATIISILVIEKVGRKILLLVSACMMGIS 319
            |...|:||::.:.::.|  |.....:::..||:|:.::||.:.|:::.||.|..|.:.:.:|..|
  Rat   297 GQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHVGSKTFLCIGSSVMAAS 361

  Fly   320 TLIMA--------------------------LYF-------------------------GMLMKS 333
            .|.|.                          |.|                         |:.:..
  Rat   362 LLTMGIVNLNINMNFTNICRSHSPLNQSLEELVFYATGNLSVSNSSLGEHLKRVTPYSKGLFIPL 426

  Fly   334 GVG------------------------------------WLALIAVCVFIIGFSLGFGPVPWLMM 362
            |.|                                    ||:|.::.|::..||:|.||:|||::
  Rat   427 GNGMEPKGEMAFTSLPNAGLSRTDRQGVTDPAVVPAVYKWLSLASLLVYVAAFSIGLGPMPWLVL 491

  Fly   363 AELFAEDVKALAGSIAGTTNWCFAFIVTLLFPVLNDIIGAT-ACFAIFFGFAVAAFVFILFLIPE 426
            :|:|...::..|.::..:.||....:::|.|..:.|:||.: .|| |:...::.:..|::..|||
  Rat   492 SEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLSWVCF-IYTVMSLTSLAFVVLFIPE 555

  Fly   427 TKGKTLNEIQAKMGE 441
            |||.:|.:|..::.:
  Rat   556 TKGCSLEQISMELSK 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	124/526 (24%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	112/476 (24%)
Slc2a12	NP_001100921.1	MFS_GLUT12_Class3	46..564	CDD:340993	124/526 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750