DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut4 and SLC2A8

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_055395.2	Gene:	SLC2A8 / 29988	HGNCID:	13812	Length:	477	Species:	Homo sapiens

Alignment Length:	455	Identity:	147/455 - (32%)
Similarity:	246/455 - (54%)	Gaps:	33/455 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FIVGFIGALGAFCLGAVIGWSGPVENEVKNS--NAYNFTPRQTEWGLVGSLMTLGAAFSCIPVGV 69
            |:..|..|||....|..:|:|.|....::.:  .|.........|  .|:::|||||...:..|.
Human    27 FLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASW--FGAVVTLGAAAGGVLGGW 89

  Fly    70 LIGKIGRKTTMLILLPPFFIGWLLILLASHIAMLLLGRFVVGFCGGAFCVTCPMYVTEIAQVQYR 134
            |:.:.|||.::|:...||..|:.:|..|..:.|||.||.:.|...|...:..|:|::|||....|
Human    90 LVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVR 154

  Fly   135 GTMGCFFQLLIVFGILYAFVVGGFVKTFYFNIACAILPVIFFVLMIFMPESPIFLAQKGKAEKAE 199
            |.:|...||::|.|||.|::.|..::..:..:...:.|.:..:||.||||:|.||..:.:.::|.
Human   155 GLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAM 219

  Fly   200 KSLKFLRGKDADVSGELKEMSAEGQKEKASVGKILCRRITLKGLFLSIGLMLFQQMTGINAIIFY 264
            .:|:||.|  ::...|...:.||.....|    :|.:....|...:.:.||.|||::|:||::||
Human   220 AALRFLWG--SEQGWEDPPIGAEQSFHLA----LLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFY 278

  Fly   265 STFIFETAGSTLEPRISTIIVGIVQAIATIISILVIEKVGRKILLLVSACMMGISTLIMALYFGM 329
            :..|||.| ...:..:::::||::|.:.|.::.|::::.||::||::|..:|..||.....||.:
Human   279 AETIFEEA-KFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKL 342

  Fly   330 LM----------------------KSGVGWLALIAVCVFIIGFSLGFGPVPWLMMAELFAEDVKA 372
            ..                      ..|:.|||:.::|:||.||::|:||:|||:|:|:|...||.
Human   343 TQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKG 407

  Fly   373 LAGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFAVAAFVFILFLIPETKGKTLNEIQA 437
            :|..|...|||..||:||..|..|.:::.....|.:...|.:.:.:|.||.:||||||||.:|.|
Human   408 VATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITA 472

Fly 438 437
Human 473 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	144/450 (32%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	127/398 (32%)
SLC2A8	NP_055395.2	Dileucine internalization motif. /evidence=ECO:0000250\|UniProtKB:Q9JJZ1	12..13
		xylE	36..472	CDD:182225	142/444 (32%)
		MFS	38..459	CDD:119392	132/429 (31%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	267..273		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8509
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.760