DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut4 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_037011.2	Gene:	Slc2a2 / 25351	RGDID:	3705	Length:	522	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	160/511 - (31%)
Similarity:	249/511 - (48%)	Gaps:	86/511 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TATQFIVGFIGALGAFCLGAVIG----------------WSGPVENEVKNSNAYNF--------- 42
            |.|.....|...||:|..|..||                ...|:::.....| |:.
  Rat     7 TGTLAFTVFTAVLGSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATIN-YDINGTDTPLIV 70

  Fly    43 TPRQTE------------------WGLVGSLMTLGAAFSCIPVGVLIGKIGRKTTMLILLPPFFI 89
            ||..|.                  |.|..|...:|...:....|.|..|:||...||........
  Rat    71 TPAHTTPDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLT 135

  Fly    90 GWLLILLA----SHIAMLLLGRFVVGFCGGAFCVTCPMYVTEIAQVQYRGTMGCFFQLLIVFGIL 150
            |.||:..:    :| |:::.||.|.|...|......|||:.|||....||.:|...||.:|.|||
  Rat   136 GALLMGCSKFGPAH-ALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGIL 199

  Fly   151 YAFVVG-GFV--KTFYFNI---ACAILPVIFFVLMIFMPESPIFLAQKGKAE-KAEKSLKFLRGK 208
            .:.:.| .|:  ...|::|   ..|:..::..:|::|.||||.:|..|.:.| :|:||||.|||.
  Rat   200 ISQIAGLSFILGNQDYWHILLGLSAVPALLQCLLLLFCPESPRYLYLKLEEEVRAKKSLKRLRGT 264

  Fly   209 DADVSGELKEMSAEGQKEKASVGKILCRRITLKGLF--------LSIGLMLF--QQMTGINAIIF 263
            : ||:.::.||..|  ||:||..    :::::..||        :.:.|||.  ||.:|||.|.:
  Rat   265 E-DVTKDINEMRKE--KEEASTE----QKVSVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFY 322

  Fly   264 YSTFIFETAGSTLEPRISTIIVGIVQAIATIISILVIEKVGRKILLLVSACMMGISTLIMALYFG 328
            |||.||:|||.: :|..:||.||.:..|.|.:|:|::||.||:.|.|  |.|:|:....:.:..|
  Rat   323 YSTSIFQTAGIS-QPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFL--AGMIGMFFCAVFMSLG 384

  Fly   329 MLMKSGVGWLALI---AVCVFIIGFSLGFGPVPWLMMAELFAEDVKALAGSIAGTTNWCFAFIVT 390
            :::.....|::.:   |:.:|:..|.:|.||:||.|:||.|::..:..|.::|..:||...||:.
  Rat   385 LVLLDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFIIA 449

  Fly   391 LLFPVLNDIIGATACFAIFFGFAVAAFVFILFL---IPETKGKTLNEIQAKMGEKA 443
            |.|..:.|.:|.    .:||.||....:|.||.   :||||||:.:||.|:..:|:
  Rat   450 LCFQYIADFLGP----YVFFLFAGVVLIFTLFTFFKVPETKGKSFDEIAAEFRKKS 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	155/496 (31%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	136/421 (32%)
Slc2a2	NP_037011.2	MFS_GLUT_Class1	12..488	CDD:340989	152/491 (31%)
Slc2a2	NP_037011.2	Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	312..318		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750