DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sut4 and Slc2a4

DIOPT Version :9

Sequence 1:	NP_523675.1	Gene:	sut4 / 36055	FlyBaseID:	FBgn0028560	Length:	444	Species:	Drosophila melanogaster
Sequence 2:	NP_036883.1	Gene:	Slc2a4 / 25139	RGDID:	2711	Length:	509	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	156/466 - (33%)
Similarity:	242/466 - (51%)	Gaps:	36/466 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TATQFIVGFIGALGAFCLGAVIGWSGPVENEVKNSNAYNFT--PRQ--------------TEWGL 51
            |.|..:..|...||:...|..||.....:..::.|  ||.|  .||              |.|.|
  Rat    21 TGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQS--YNATWLGRQGPGGPDSIPQGTLTTLWAL 83

  Fly    52 VGSLMTLGAAFSCIPVGVLIGKIGRKTTMLILLPPFFIGWLLILLASHIA---MLLLGRFVVGFC 113
            ..::.::|...|...:|::...:|||..||.......:|..|:.||:..|   :|:||||::|..
  Rat    84 SVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAY 148

  Fly   114 GGAFCVTCPMYVTEIAQVQYRGTMGCFFQLLIVFGILYAFVVG-----GFVKTFYFNIACAILPV 173
            .|......||||.|||....||.:|...||.||.|||.|.|:|     |....:...:|..:||.
  Rat   149 SGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLAITVLPA 213

  Fly   174 IFFVLMI-FMPESPIFLAQKGKAE-KAEKSLKFLRGKDADVSGELKEMSAEGQK----EKASVGK 232
            :..:|:: |.||||.:|......| .|.||||.|.|. ||||..|.|:..|.:|    ...|:.:
  Rat   214 LLQLLLLPFCPESPRYLYIIRNLEGPARKSLKRLTGW-ADVSDALAELKDEKRKLERERPLSLLQ 277

  Fly   233 ILCRRITLKGLFLSIGLMLFQQMTGINAIIFYSTFIFETAGSTLEPRISTIIVGIVQAIATIISI 297
            :|..|...:.|.:::.|.|.||::||||:.:|||.|||.|| ..:|..:||..|:|..:.|::|:
  Rat   278 LLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAG-VEQPAYATIGAGVVNTVFTLVSV 341

  Fly   298 LVIEKVGRKIL-LLVSACMMGISTLIMALYFGMLMKSGVGWLALIAVCVFIIGFSLGFGPVPWLM 361
            |::|:.||:.| ||..|.|.|.:.|:......:.....:.:::::|:..|:..|.:|.||:||.:
  Rat   342 LLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPSMSYVSIVAIFGFVAFFEIGPGPIPWFI 406

  Fly   362 MAELFAEDVKALAGSIAGTTNWCFAFIVTLLFPVLNDIIGATACFAIFFGFAVAAFVFILFLIPE 426
            :||||::..:..|.::||.:||...|||.:.|..:.|.:|... |.:|....:..|:|....:||
  Rat   407 VAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYV-FLLFAVLLLGFFIFTFLRVPE 470

  Fly   427 TKGKTLNEIQA 437
            |:|:|.::|.|
  Rat   471 TRGRTFDQISA 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sut4	NP_523675.1	Sugar_tr	9..436	CDD:278511	152/457 (33%)
sut4	NP_523675.1	MFS	47..424	CDD:119392	135/391 (35%)
Slc2a4	NP_036883.1	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	154/460 (33%)
		MFS	78..447	CDD:119392	130/370 (35%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740