Protein Alignment egr and EDA

DIOPT Version :9

• Sequence 1: NP_724878.2
• Gene: egr / 36054
• FlyBaseID: FBgn0033483
• Length: 415
• Species: Drosophila melanogaster
• Sequence 2: NP_001390.1
• Gene: EDA / 1896
• HGNCID: 3157
• Length: 391
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 87/462 - (18%)
• Similarity: 146/462 - (31%)
• Gaps: 170/462 - (36%)

  Fly    19 GFPAKATSTATAQRRTRQLIPLVLGFIGLGLVVAILALTIWQTTRVSHLDKELKSLKRVVDNLQQ 83
            |.||:|....:..        |.|||.||.|.:.:|.|..:         .||:|..|.....:.
Human    29 GAPARAGEGNSCL--------LFLGFFGLSLALHLLTLCCY---------LELRSELRRERGAES 76

  Fly    84 RLGINYLDEFDEFQKEYENALIDYPKKVDGLTDEEDDDDGDG-------LDSIAD-DEDDDVSYS 140
            |||                                    |.|       |.|:.. |.|..::
Human    77 RLG------------------------------------GSGTPGTSGTLSSLGGLDPDSPIT-- 103

  Fly   141 SVDDVGADYEDYTDMLNKLNNAHTG-TTPTSETTAEGEGETDSASSASNDDNVFDDFTSYNAHKK 204
                                 :|.| .:|..:....||....|.|...:...:.:.|  :...|.
Human   104 ---------------------SHLGQPSPKQQPLEPGEAALHSDSQDGHQMALLNFF--FPDEKP 145

  Fly   205 KQERKSRSIADVRNEEQNIQGNHTELQEKSSNEATSKESP-----------------------AP 246
            ..|.:||.:...:..:.| :|....::.|...:......|                       .|
Human   146 YSEEESRRVRRNKRSKSN-EGADGPVKNKKKGKKAGPPGPNGPPGPPGPPGPQGPPGIPGIPGIP 209

  Fly   247 LHHRRRMHSRHRHLLVRKGESLL-------------------------SARSEDSRPAAHFHLSS 286
                              |.:::                         .|.:.:::||. .||..
Human   210 ------------------GTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTRENQPAV-VHLQG 255

  Fly   287 RRRHQGS-MGYHGDMYIG--NDNER---NSYQGHFQTRDGVLTVTNTGLYYVYAQ--ICYNNSHD 343
                ||| :....|:..|  ||..|   |........|.|.|.|...|.|::|:|  :.|.|..|
Human   256 ----QGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEVYYINFTD 316

  Fly   344 QNGFIVFQGDTPFLQCLNTVPTNMPHKVHTCHTSGLIHLERNERIHLKDIHNDRNAVLREGNNRS 408
            ...:.|...:.|||||..::.|...: .:||:|:|:..|:..::|.:|.:|.|.:  :....:.:
Human   317 FASYEVVVDEKPFLQCTRSIETGKTN-YNTCYTAGVCLLKARQKIAVKMVHADIS--INMSKHTT 378

  Fly   409 YFGIFKV 415
            :||..::
Human   379 FFGAIRL 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egr	NP_724878.2	TNF	278..413	CDD:238108	42/142 (30%)
EDA	NP_001390.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..127		15/112 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..245		10/117 (9%)
		TNF	249..383	CDD:320782	41/141 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11711
eggNOG	1	0.900	-	-		E1_28MSH
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6553
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15151
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860