DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1371 and nomo3

DIOPT Version :9

Sequence 1:	NP_610551.1	Gene:	CG1371 / 36053	FlyBaseID:	FBgn0033482	Length:	1199	Species:	Drosophila melanogaster
Sequence 2:	NP_001121443.1	Gene:	nomo3 / 100158535	XenbaseID:	XB-GENE-949390	Length:	1209	Species:	Xenopus tropicalis

Alignment Length:	1215	Identity:	392/1215 - (32%)
Similarity:	611/1215 - (50%)	Gaps:	95/1215 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AGEVEVVGCGGFIKSHAEIDFSRVEIKLLTKQGSLKDKTDCSPSNGYYFLPIYDKGDYLLSISPP 85
            |.|..|||||||:||..:|::|.:||||.||||:||.:|||:|.|||:.:|:|||||::|.|.||
Frog    20 ASEDIVVGCGGFVKSDVDINYSLIEIKLYTKQGTLKYQTDCAPINGYFMIPLYDKGDFVLKIEPP 84

  Fly    86 PGWSFEPEQVELNFDGKTDVCSQGRDVNFVFKGFGITGQV-ALAAGGGARGVDVELRSEQGEV-- 147
            .||||||..|.|:.||..|:|::|.||||||.||.:.|:| :.....|..||.|.:|.....|
Frog    85 LGWSFEPTSVPLHVDGVNDICTKGEDVNFVFNGFSVNGKVLSRNQNMGPVGVQVAMRKAGSSVNL 149

  Fly   148 RRTKSDANGVFSFTPIIPGNYVVKASHARWHFSKAEHKVVVVSGNTELPANSLVVSGFDVVGRFD 212
            :.|.:...|.|:||.::||.|.:.|||..|...:|...|.|.:.|.: .||:|:|:|:||.|...
Frog   150 QTTVTQVGGKFAFTKVLPGEYEIFASHPTWTLKQATTMVQVTNSNAQ-AANALIVAGYDVSGSVR 213

  Fly   213 S-SSPLPGNLGVALYKKKGQSLVPKCETSSPAPPNSVNSAYESAS-SCFSQLDKSGEYIFKNVPS 275
            | ..|:.|.:.:..........:..|:.|   |........||.| .|.....:.|.:.|.::||
Frog   214 SDGEPMKGVMFLLFSTTTKSEDILGCDLS---PVEGFQGKDESLSYLCHVTSQEDGSFTFLSLPS 275

  Fly   276 GKYLLQAINLDSKLKLHLSPELLELEVGKDTLQIKDEFKITGFTVSGRVLTSAGGEPLKSAVIKV 340
            |.|.:.......::...::|..|:..|..|:|:::..|.:.||:|:||||....|:.:..|::.:
Frog   276 GDYSVVPYYRGERITFDVAPSRLDFSVEHDSLKLEPVFHVMGFSVTGRVLNGPEGDGVPDAMVTL 340

  Fly   341 NGKKVAETDAQGSYTLENLKAGTVNIEVESSQLQFSPLQVKAQINTASLPTIVPSAYEVCGKVV- 404
            |.:....|:|.||:.|||:.|||.:|:.:...:.|..|.||...||..|..|:.:.:.|||::.
Frog   341 NNQMKVVTNADGSFRLENMTAGTYSIDAQKEHIYFDTLTVKIAPNTPQLADIIAARFSVCGQITI 405

  Fly   405 --SPKS------HNVGLTKIGSTFHSSASTNAET-GNWCAFLPVGKYTIEVLTTDADKAAGVQFF 460
              .|::      :.:.||......:...:|.::: ||:|.....|.|.::|...:.|..||:...
Frog   406 THFPENVRQFSKYKMTLTPQDKERNPVLTTESDSQGNFCFQAKRGSYDLQVTVPEHDARAGLAIK 470

  Fly   461 PVQQQTEVRDAPVNGITFSQLRAKIRGELQCLPDATATCTSAEVTLQALDATGQPTENKWKARAH 525
            |......|.|.||..|:|||..|.:.|::.||.    ||....||||:..............:|.
Frog   471 PAVFSVTVVDRPVMDISFSQFMASVSGKISCLD----TCGDLTVTLQSTTRQRDKRSVMVSGKAD 531

  Fly   526 RGKYVFKDMLPGPYELTIPQGNLCYESTRVFLNVASAEEDAPPFVHKGYEVSIISSHRALMK-YT 589
            ...:.|:::|||.|:::|.|.:.|:::..:...|...:.....|...|:.:....||...:: |.
Frog   532 NVPFNFENVLPGKYKVSIVQEDWCWKNKSLEFEVVEEDIVGVEFRQTGFMLRCSLSHAITLEFYQ 596

  Fly   590 HVTGPSEPKAPTESLKIASGVNTFCVKKYGSYDFKLEGCH-------TYDESLPSKF-------- 639
            ...||..    .....::.|||.||:.|.|.|......||       |||.|.||..
Frog   597 DGNGPEH----VGVYNLSKGVNRFCLSKPGVYKVTPRSCHRFEHPYYTYDTSSPSILTLTAVRHH 657

  Fly   640 ----ITPEPDQLQ--TLIINAVAHKTGVRVL----STEPTADSIKLV------LESESLGQEVI- 687
                ||  .|||.  |:.|.:........||    |.|.|....::.      ||.|..|.|..
Frog   658 VLGAIT--ADQLMDVTVTIKSSIDSEPALVLGPLKSVEETRREQQMAEIEARRLEREKAGSEDAE 720

  Fly   688 --TPVAE-SHKVDGKFAYRYDTYLKPEQVLRITPVSDVLLFAPQQHE-IVGSSDCVDIAFNFVAT 748
              .||.| ...:.|.|:|.:..:.:..:.:.:||.|..|||.|...| :|...:|..........
Frog   721 SQPPVQELVDDLQGPFSYEFSYWARSGEKITVTPSSKELLFYPSSVEAVVSGENCPGKMIEIQGK 785

  Fly   749 RGLILRGKVVPAIKDAKITLSFPDQPELESLEVLTSVTGEFKFGPIEESLAFDLKAEKESYVFSD 813
            .||.|.|::.|.::..:|.:|...... ..:.|.|...|.:..||:...|.:.:.|:||.:|.:.
Frog   786 AGLFLEGQIHPELEGVEIVISEKGAAS-PLITVYTDDKGSYSVGPLHSDLEYTISAQKEGFVMTA 849

  Fly   814 YNRQTASFSAHKLCEISVVVKDEAGQTLGGVLLSLSGGESYRKNLVTGDNGAINFHSLSPSQYYL 878
            .......|:|..|..::..::.|.||.|.||||||||| .:|.||:|.:||.:.|.:|||.|||.
Frog   850 LEGTMGDFNAFALAGVTFEIRSEDGQPLAGVLLSLSGG-IFRSNLLTQENGMLTFSNLSPGQYYF 913

  Fly   879 RPMMKEYKFEPNSKMIDIKDGETVSVTLVGKRFAYSIFGTVSSLNGDPFAGVNVQATADNSCPQQ 943
            :|||||::|||:|:||:.::|:.:.:|::|.|.|||.:||||||||:|..||:|:|.....|...
Frog   914 KPMMKEFRFEPSSQMIEAQEGQNLKITIIGHRTAYSCYGTVSSLNGEPEQGVSVEAIGQGDCSIY 978

  Fly   944 PEEATSEANGQYRIRGLQPGCSYSVRVVPD-KEIVERSIPAQHTVKVANEDVRDINLVAISPLKI 1007
            .|:..::.:|::|:|||:|||.|.|::..: .:.:||::|:...:.|.:.|:.|:|::|...:..
Frog   979 GEDTVTDEDGKFRLRGLRPGCVYHVQLKSEGNDHIERALPSYRAIGVGSNDIDDVNIIAFRQINQ 1043

  Fly  1008 VDITARVTATLNEHYKTLRIVMYRKGNSDSPVFSQRVGTPVNPKARLNPGITVFFPRIPLDGKSY 1072
            .|::..: .|.:||..||.:.:|:..|.|:|:.|..:|          ..:...||.:..||::|
Frog  1044 FDLSGNI-ITSSEHLSTLLVKLYKSENLDNPIQSVSLG----------QSLFFHFPPLLRDGENY 1097

  Fly  1073 VVELQSTLSDKTYTYKLPSTTFVADRGSVFVELEFKPEVRAAEADLNQNSISALVLIALVAIAFF 1137
            ||:|.|||....|.|.||..:|........:.|.|.|..:..|.|:.|.|..||.|..|:.:|.:
Frog  1098 VVQLDSTLPKSQYDYTLPQVSFSTQGYHKHITLTFSPTRKLPEQDVVQGSYLALPLTLLLLLAGY 1162

  Fly  1138 KQDLATSFLSFVWSKLNDV---------------AADLAQRQKSK 1167
            ..|.....|..:.|:|..|               |..|.:|||::
Frog  1163 NHDKLIPLLLQLTSRLQGVRALGQANSDNGSPEDAKRLPKRQKTR 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1371	NP_610551.1	CarboxypepD_reg	120..198	CDD:290350	24/80 (30%)
		CarboxypepD_reg	319..>370	CDD:290350	19/50 (38%)
		Peptidase_M14NE-CP-C_like	841..905	CDD:304370	35/63 (56%)
		CarboxypepD_reg	914..>970	CDD:290350	26/55 (47%)
nomo3	NP_001121443.1	CarboxypepD_reg	119..185	CDD:290350	20/65 (31%)
		CarboxypepD_reg	319..392	CDD:290350	26/72 (36%)
		Cna_B	862..>914	CDD:283411	27/52 (52%)
		CarboxypepD_reg	952..>1009	CDD:290350	25/56 (45%)
		NTR_like	1042..>1099	CDD:295338	17/67 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	219	1.000	Domainoid score	I2596
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13810
Inparanoid	1	1.050	612	1.000	Inparanoid score	I900
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D361344at33208
OrthoFinder	1	1.000	-	-		FOG0005163
OrthoInspector	1	1.000	-	-		oto102747
Panther	1	1.100	-	-	LDO	PTHR23303
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3347
SonicParanoid	1	1.000	-	-		X3681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190