Protein Alignment Cdc2rk and CDK11B

DIOPT Version :9

• Sequence 1: NP_523674.1
• Gene: Cdc2rk / 36051
• FlyBaseID: FBgn0013435
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: XP_011540792.1
• Gene: CDK11B / 984
• HGNCID: 1729
• Length: 804
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 176/373 - (47%)
• Similarity: 247/373 - (66%)
• Gaps: 21/373 - (5%)

  Fly     2 SSLKSND-VDTNPAPDPQAPITRKGFLMSLNTGTPMPIPEQNLFGRCRPVSEFEKLNRVGEGSYG 65
            |:|...| |..:||..|          :.|....|..:|.  |.| ||.|.||:.|||:.||:||
Human   408 SALTEGDYVPDSPALSP----------IELKQELPKYLPA--LQG-CRSVEEFQCLNRIEEGTYG 459

  Fly    66 IVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFLV 130
            :||||:|.:::||||||:::|::||:|.||:.||||..:.:..|.|||.:||:|||.::|.|::|
Human   460 VVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIV 524

  Fly   131 MDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVAD 195
            |::.|.||.|:::.|.|||...|||.:.:|:|:.:|:||..:::|||||.||||::..|.:||.|
Human   525 MNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGD 589

  Fly   196 FGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLLGKPLLPGNSEIA 260
            |||||.:.:|.|..||.:|||||||||||||.:.::||||||:.|||.||||..|||.||.|||.
Human   590 FGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEID 654

  Fly   261 QLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKF-HMIGQSGRNLLNILFIYNPKT 324
            |::.:...||.|||.||||:::||||:..|.|:.|||||..:| .::...|.:|:|....|.|..
Human   655 QINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 719

  Fly   325 RATAEECLKSKYFVDPPQACDPGMMPTFP----QHRNNAAPAPAVQPP 368
            |.:||:.||.:||.:.|...||.|.||:|    |.|.....:|  :||
Human   720 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSP--RPP 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	159/308 (52%)
		S_TKc	53..337	CDD:214567	146/284 (51%)
CDK11B	XP_011540792.1	STKc_CDC2L1	441..732	CDD:173741	150/290 (52%)
		PLN00009	444..734	CDD:177649	150/289 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0663
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392617at33208
OrthoFinder	1	1.000	-	-		FOG0001516
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850