DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc2rk and cdk10

DIOPT Version :9

Sequence 1:	NP_523674.1	Gene:	Cdc2rk / 36051	FlyBaseID:	FBgn0013435	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001017622.2	Gene:	cdk10 / 550285	ZFINID:	ZDB-GENE-050417-94	Length:	360	Species:	Danio rerio

Alignment Length:	350	Identity:	220/350 - (62%)
Similarity:	268/350 - (76%)	Gaps:	11/350 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DVDTNPAPDPQAPITRKGFLMSLNTGTPMPIPEQNLFGRCRPVSEFEKLNRVGEGSYGIVYRARD 72
            |.|..|..           |.||.|.....||.....|:||.|.||||:||:|||:|||||||||
Zfish     6 DTDLEPLK-----------LKSLKTDRTFVIPHSERLGKCRSVKEFEKINRIGEGTYGIVYRARD 59

  Fly    73 TRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQD 137
            ||:||||||||||||:||||:|||.||||.:|.:..|.|||.|:|||||..|:|:||||.:||||
Zfish    60 TRTNEIVALKKVRMDKEKDGIPISSLREINLLIRLRHPNIVELKEVVVGSHLESLFLVMSYCEQD 124

  Fly   138 LASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMF 202
            |||:|:||..||:|::||||.||:||.|.|||..|::||||||||||||||||:|:|||||||::
Zfish   125 LASLLENMQSPFSEAQVKCIVLQLLKGLAYLHHNFILHRDLKVSNLLMTDKGCVKIADFGLARVY 189

  Fly   203 SNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIID 267
            ..|.:||||::|||||||||||||.:|.|||:||||.|||..|||..||||||.|||.|||:|:.
Zfish   190 GIPLQPMTPRVVTLWYRAPELLLGTKTQTTALDMWAVGCIFAELLAHKPLLPGASEIQQLDLIVQ 254

  Fly   268 LLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECL 332
            |||.|:|||||||:.||.|..::|.:||||||..||..:.::|..|||:||:|||:.||||.:||
Zfish   255 LLGTPNESIWPGFSRLPLVGQYSLRKQPYNNLKNKFTWLSEAGLRLLNLLFMYNPQRRATAIDCL 319

  Fly   333 KSKYFVDPPQACDPGMMPTFPQHRN 357
            :|.||.:.|..|:|.:|||||.|||
Zfish   320 ESSYFKEKPLPCEPELMPTFPHHRN 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	206/307 (67%)
Cdc2rk	NP_523674.1	S_TKc	53..337	CDD:214567	193/283 (68%)
cdk10	NP_001017622.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590382
Domainoid	1	1.000	413	1.000	Domainoid score	I646
eggNOG	1	0.900	-	-		E1_KOG0663
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55769
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1545
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D392617at33208
OrthoFinder	1	1.000	-	-		FOG0001516
OrthoInspector	1	1.000	-	-		oto41705
orthoMCL	1	0.900	-	-		OOG6_105129
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R970
SonicParanoid	1	1.000	-	-		X6106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800