DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc2rk and CDK12

DIOPT Version :9

Sequence 1:	NP_523674.1	Gene:	Cdc2rk / 36051	FlyBaseID:	FBgn0013435	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_057591.2	Gene:	CDK12 / 51755	HGNCID:	24224	Length:	1490	Species:	Homo sapiens

Alignment Length:	423	Identity:	142/423 - (33%)
Similarity:	224/423 - (52%)	Gaps:	58/423 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LKSNDVDTNPAPDPQA------PITRKGFLMSLNTGTPMPIPEQNLFGRCRPVSEFEKLNRVGEG 62
            |...|:....:|:|:|      |..::..:.....|.... .|.:...||  |.:|:.:..:|||
Human   675 LPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQ-TESDWGKRC--VDKFDIIGIIGEG 736

  Fly    63 SYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGK--SLD 125
            :||.||:|:|..:.|:|||||||:|.||:|.||:.:|||.||:|..|.::|.::|:|..|  :||
Human   737 TYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALD 801

  Fly   126 ------SIFLVMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLL 184
                  :.:||.::.:.||..:|::....|:|..:|....|:::.|:|.|.:..:|||:|.||:|
Human   802 FKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNIL 866

  Fly   185 MTDKGCIKVADFGLARMF-SNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLL 248
            :.:.|.||:|||||||:: |...:|.|.:::|||||.||||||...:|.|:|:|:.|||||||..
Human   867 LNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFT 931

  Fly   249 GKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNL 313
            .||:...|.|:|||::|..|.|:|..::||....||........:|....|..:|..|..:..:|
Human   932 KKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDL 996

  Fly   314 LNILFIYNPKTRATAEECLKSKYFVD-------PP-----QAC------------DPGMMPTFP- 353
            |:.:...:|..|.|||:.|:|.:..|       ||     |.|            ..|::...|
Human   997 LDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPP 1061

  Fly   354 ---------------QHRNNAAPAPAVQPPADI 371
                           :...|::|||....|..:
Human  1062 PSKTSRKETTSGTSTEPVKNSSPAPPQPAPGKV 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	128/340 (38%)
Cdc2rk	NP_523674.1	S_TKc	53..337	CDD:214567	119/292 (41%)
CDK12	NP_057591.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..703		6/27 (22%)
		STKc_CDK12	719..1020	CDD:270847	122/302 (40%)
		S_TKc	727..1020	CDD:214567	119/292 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1047..1098		7/48 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1161..1189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1220..1348
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1441..1460
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1466..1490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920