Protein Alignment Cdc2rk and Cdk12

DIOPT Version :10

• Sequence 1: NP_523674.1
• Gene: Cdc2rk / 36051
• FlyBaseID: FBgn0013435
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 319
• Identity: 126/319 - (39%)
• Similarity: 191/319 - (59%)
• Gaps: 17/319 - (5%)

  Fly    46 RCRPVSEFEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHE 110
            ||  |..||.:.::|||:||.||:|||..:|::|||||||::.||:|.||:.:|||.||:|.:|.
  Fly   799 RC--VDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHR 861

  Fly   111 NIVRLREVVVG--------KSLDSIFLVMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKY 167
            |||.|.|:|..        |...|.:||.::.:.||..:|::....|.|.....|..|:|..|.|
  Fly   862 NIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNY 926

  Fly   168 LHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFS--NPPKPMTPQMVTLWYRAPELLLGCRTH 230
            .|.:..:|||:|.||:||.::|.:|:|||||||:::  :..:|.|.:::|||||.||||||...:
  Fly   927 CHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERY 991

  Fly   231 TTAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQP 295
            ..::|:|:.|||||||.:.:||...|:|:|||:.|..:.|:|..::||....||........:..
  Fly   992 GPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTH 1056

  Fly   296 YNNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYFVDPPQACDPGMMPTFPQ 354
            ...|...|..:.....:||:.:...:|..|.|||:.|:|.:.    :..:|..||| ||
  Fly  1057 RRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWL----RKINPDEMPT-PQ 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	124/316 (39%)
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	120/300 (40%)