DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc2rk and Cdk10

DIOPT Version :9

Sequence 1:	NP_523674.1	Gene:	Cdc2rk / 36051	FlyBaseID:	FBgn0013435	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_919428.1	Gene:	Cdk10 / 234854	MGIID:	2448549	Length:	360	Species:	Mus musculus

Alignment Length:	345	Identity:	220/345 - (63%)
Similarity:	270/345 - (78%)	Gaps:	10/345 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ITRKGFLMSLNTGTPMPIPEQNLFGRCRPVSEFEKLNRVGEGSYGIVYRARDTRSNEIVALKKVR 85
            |.::||         ..:|.::..||||.|.|||||||:|||:||||||||||:::|||||||||
Mouse    16 IRKEGF---------FTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVR 71

  Fly    86 MDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQDLASVLDNMSQPFT 150
            ||:||||:|||.||||.:|.:..|.|||.|:|||||..|:||||||.:|||||||:|:||..||:
Mouse    72 MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFS 136

  Fly   151 ESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVT 215
            |::||||.||||:.|:|||..|:|||||||||||||||||:|.|||||||.:..|.|||||::||
Mouse   137 EAQVKCIMLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVT 201

  Fly   216 LWYRAPELLLGCRTHTTAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGF 280
            |||||||||||..|.||::||||.||||.|||..||||||.|||.|:|:|:.|||.|||:|||||
Mouse   202 LWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPSENIWPGF 266

  Fly   281 ADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYFVDPPQACD 345
            :.||....::|.:||||||..||..:.::|..|||.||:|:||.|||:.:||:|.||.:.|..|:
Mouse   267 SKLPLAGQYSLRKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATSGDCLESSYFKEKPLPCE 331

  Fly   346 PGMMPTFPQHRN-NAAPAPA 364
            |.:|||||.||| .||||.|
Mouse   332 PELMPTFPHHRNKRAAPAAA 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	206/307 (67%)
Cdc2rk	NP_523674.1	S_TKc	53..337	CDD:214567	192/283 (68%)
Cdk10	NP_919428.1	STKc_CDK10	31..339	CDD:173742	206/307 (67%)
		PTZ00024	43..336	CDD:240233	193/292 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..360		13/18 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845742
Domainoid	1	1.000	407	1.000	Domainoid score	I702
eggNOG	1	0.900	-	-		E1_KOG0663
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55769
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1575
Isobase	1	0.950	-	0	Normalized mean entropy	S896
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D392617at33208
OrthoFinder	1	1.000	-	-		FOG0001516
OrthoInspector	1	1.000	-	-		oto92126
orthoMCL	1	0.900	-	-		OOG6_105129
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R970
SonicParanoid	1	1.000	-	-		X6106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750