DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc2rk and Cdk12

DIOPT Version :9

Sequence 1:	NP_523674.1	Gene:	Cdc2rk / 36051	FlyBaseID:	FBgn0013435	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001029039.1	Gene:	Cdk12 / 192350	RGDID:	621111	Length:	1484	Species:	Rattus norvegicus

Alignment Length:	357	Identity:	134/357 - (37%)
Similarity:	207/357 - (57%)	Gaps:	29/357 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DTNPAPD---------PQAPITRKGFLMSLNTGTPMPIPEQNLFGRCRPVSEFEKLNRVGEGSYG 65
            |.:| ||         ||.|..::..:.....|.... .|.:...||  |.:|:.:..:|||:||
  Rat   675 DPSP-PDSPEPKAITPPQQPYKKRPKICCPRYGERRQ-TESDWGKRC--VDKFDIIGIIGEGTYG 735

  Fly    66 IVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGK--SLD--- 125
            .||:|:|..:.|:|||||||:|.||:|.||:.:|||.||:|..|:::|.::|:|..|  :||
  Rat   736 QVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKK 800

  Fly   126 ---SIFLVMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTD 187
               :.:||.::.:.||..:|::....|:|..:|....|:::.|.|.|.:..:|||:|.||:|:.:
  Rat   801 DKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNN 865

  Fly   188 KGCIKVADFGLARMF-SNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLLGKP 251
            .|.||:|||||||:: |...:|.|.:::|||||.||||||...:|.|:|:|:.|||||||...||
  Rat   866 SGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKP 930

  Fly   252 LLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNI 316
            :...|.|:|||::|..|.|:|..::||....||........:|....|..:|..|..:..:||:.
  Rat   931 IFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDH 995

  Fly   317 LFIYNPKTRATAEECLKSKYFVD-------PP 341
            :...:|..|.|||:.|:|.:..|       ||
  Rat   996 MLTLDPSKRCTAEQTLQSDFLKDVELSKMAPP 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	125/313 (40%)
Cdc2rk	NP_523674.1	S_TKc	53..337	CDD:214567	119/292 (41%)
Cdk12	NP_001029039.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..699		7/24 (29%)
		STKc_CDK12	715..1016	CDD:270847	122/302 (40%)
		S_TKc	723..1016	CDD:214567	119/292 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1218..1356
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920