DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-N and Enpp1

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_445987.1	Gene:	Enpp1 / 85496	RGDID:	628825	Length:	906	Species:	Rattus norvegicus

Alignment Length:	743	Identity:	140/743 - (18%)
Similarity:	238/743 - (32%)	Gaps:	288/743 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPANRLVLIVTDGFRADSFFE-----------ENC-RYVPNLRKIFLREGVVGVSRTRVPTETRP 95
            ||.   :|...|||||:....           :|| .|..|:|.::             ||:|.|
  Rat   192 PPT---LLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPVY-------------PTKTFP 240

  Fly    96 GHITLIAGLYEDPSAVLRG-----------------------WKSNPIDFDTVFNRS--SQTYAW 135
            .|.:::.|||.:...::..                       :|..|| :.|..::.  |.||.|
  Rat   241 NHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPI-WVTANHQEVRSGTYFW 304

  Fly   136 GANDVLNVFSHVSNGGEIN------LRFYNHDLDFSPGYDAYEEDEWVFKRVKLLLQQKREALQR 194
            ..:||           ||:      .:.||..:.|.             :|:..:|:..:  |..
  Rat   305 PGSDV-----------EIDGILPDIYKVYNGSVPFE-------------ERILAVLEWLQ--LPS 343

  Fly   195 AQNVVFF-LHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGM 258
            .:...|: |:|...|::||.|.|.:.:..:.|:|.:..|..:....:.:..||....:|.:||||
  Rat   344 YERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILISDHGM 408

  Fly   259 TDSGAHGSGSPH--------ETDTPFMLWGAGA---SRAVP------------------------ 288
                ..||...:        :.:...:::|..|   ...||
  Rat   409 ----EQGSCKKYVYLNKYLGDVNNVKVVYGPAARLRPTEVPETYYSFNYEALAKNLSCRETNQHF 469

  Fly   289 KPGGRTFMPNNEGPAMPLHELEQAQLTPLMSAL-----LGLAPP---------------MNNFGK 333
            :|..:.|:|..      ||..:..::.||...|     |.|.|.               .:|...
  Rat   470 RPYLKHFLPKR------LHFAKNDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNLFSNMQA 528

  Fly   334 LPLGYLNVSKEYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAEAIKRYKDTIVQL 398
            |.:||....|.    .|.|::.:.:|.|         ....|:|......|.|:    ..::..|
  Rat   529 LFIGYGPAFKH----GAEVDSFENIEVY---------NLMCDLLGLIPAPNNES----HGSLNHL 576

  Fly   399 QKKREYSLCIDKSQVIMSQA-LEGIDYYHGY-----------YRRVLLLSTTSTFLGWMFYIYRL 451
            .||..|:....|.:..:||. ::.:....|.           :.:...|:|.:....:...:...
  Rat   577 LKKPIYTPSHPKEESFLSQCPIKSVSSDLGCTCDPSIVPIMDFEKQFNLTTDAVEDVYSMTVPNG 641

  Fly   452 LSRNRASKVELVLERSNKIVRVSIVSSVIVLIICLLSQ-----GTPLDISFYLLLPYFVWLKALQ 511
            ..||        |::.::              :|||.|     |..||    ||:|  :|
  Rat   642 RPRN--------LQKQHR--------------VCLLHQQQFLTGYSLD----LLMP--LW----- 673

  Fly   512 PWNINFSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIALCFCVFACYNSWENFQWK 576
                                ||               :||.                  .|.|:.
  Rat   674 --------------------TS---------------YTFL------------------SNDQFS 685

  Fly   577 SRDFFSWLALVLILSCFPLLPLSVGYQNGYLLGAGVIVIFTNSFWNSKSRLCYRNHTKYSNALIL 641
            :.||.:.|...|.:...|:...|. |::...|..|.:   |....|..||..|......||.:.:
  Rat   686 TDDFSNCLYQDLRIPLSPMHKCSY-YKSTSKLSYGFL---TPPRLNRVSRQIYSEALLTSNIVPM 746

  Fly   642 LQT--ILCAYLHS----------NGINI 657
            .|:  ::..|||.          ||:|:
  Rat   747 YQSFQVIWQYLHDTVLRRYAQERNGVNV 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	57/265 (22%)
		GPI_EPT_1	42..335	CDD:293744	75/390 (19%)
		PigN	421..834	CDD:282796	46/265 (17%)
Enpp1	NP_445987.1	cytoplasmic tail	1..58
		transmembrane domain	59..79
		SO	86..126	CDD:197571
		cysteine-rich domain	87..168
		SO	127..170	CDD:197571
		catalytic domain	191..573		87/450 (19%)
		Phosphodiest	194..520	CDD:366747	72/378 (19%)
		Linker. /evidence=ECO:0000250\|UniProtKB:P06802	579..628		7/48 (15%)
		nuclease-like domain	639..906		43/226 (19%)
		NUC	657..888	CDD:214683	37/186 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810