DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and MCD4

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_012756.1	Gene:	MCD4 / 853690	SGDID:	S000001648	Length:	919	Species:	Saccharomyces cerevisiae

Alignment Length:	936	Identity:	277/936 - (29%)
Similarity:	477/936 - (50%)	Gaps:	98/936 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MW-------IAYALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRA 58
            ||       :|..::.|:..|.|||.|||.||::.|::|.:..    ..|||.||.|||.||.||
Yeast     1 MWNKTRTTLLAVGVLFHLFYLWSIFDIYFISPLVHGMSPYQST----PTPPAKRLFLIVGDGLRA 61

  Fly    59 DSFFEENCRYV--------PNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGW 115
            |:.|::....|        |.:|.:.:.....|:|.||:|||:||||:.:|||.|||.|||.:||
Yeast    62 DTTFDKVTHPVSGKTEFLAPFIRSLVMNNATYGISHTRMPTESRPGHVAMIAGFYEDVSAVTKGW 126

  Fly   116 KSNPIDFDTVFNRSSQTYAWGANDVLNVFSH-VSNGGEINLRFYNHDL-DFSPGYDAYEEDEWVF 178
            ||||::||:.||:|:.||::|:.|:|.:|.. .|:..:::...|:|.. ||:  ..:.|.|.:||
Yeast   127 KSNPVNFDSFFNQSTHTYSFGSPDILPMFKDGASDPNKVDTWMYDHTFEDFT--QSSIELDAFVF 189

  Fly   179 KRVKLL-----LQQKREALQRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQE 238
            :.:..|     |....:...|....||||||||.|||||.::|.:.::...::..:..:..:..:
Yeast   190 RHLDQLFHNSTLNSTLDYEIRQDGNVFFLHLLGCDTAGHSYRPYSAEYYDNVKYIDDQIPILIDK 254

  Fly   239 FERVFPDKRTAYLLTADHGMTDSGAHGSGSPHETDTPFMLWGAGASRAV--PKPGGRTFMPNNEG 301
            ..:.|.|.:||::.||||||:..|:||.|.|:.|.||.:.||||.::.|  |.|....:..|.|.
Yeast   255 VNKFFADDKTAFIFTADHGMSAFGSHGDGHPNNTRTPLVAWGAGLNKPVHNPFPVSDNYTENWEL 319

  Fly   302 PAMPLHELEQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEYEAMAA-HVNALQLLEQYVALQ 365
            .::..::::||.:..|||.|:|:..|.|:.|:||:.|:: .||.:.:|| :.||..:||||:..|
Yeast   320 SSIKRNDVKQADIASLMSYLIGVNYPKNSVGELPIAYID-GKESDKLAALYNNARSILEQYLVKQ 383

  Fly   366 KQ--HKKGFFADILLEYDVLNAEAIKRYKDTIVQLQKKREY--SLCIDKSQVIMSQALEGIDYYH 426
            .:  ..:.|:.:.....:..::..::..:..|.::.:...|  ...|..::.:|...|||:.|..
Yeast   384 DEVIDSQFFYKEYFKFVEKSHSHYLEEIETLIQRISEGENYLEQEAITLTEELMQITLEGLHYLT 448

  Fly   427 GYYRRVLLLSTTSTFLGWMFYIYRLLSRNRASKVELVLERSNKIVRVSIVSSVIVLIICLLSQGT 491
            .|..|.:....|..|:||:|:.:.:..::...:..:..::::.:......|..|:|...|..|.:
Yeast   449 TYNWRFIRTIVTFGFVGWIFFSFIIFLKSFILENVIDDQKASPLSHAVFGSIGILLNWILFYQHS 513

  Fly   492 PLDISFYLLLP-YFVWLKALQPWNINFSSSPASAYSVPAL--QTSMWQLVL----LIACAELMVF 549
            |.:...|||.| ||        |:..|::.......:...  .||.|:.||    :|:..|.:|:
Yeast   514 PFNFYMYLLFPLYF--------WSYIFTNRSVLRSGIKEFFKGTSPWKRVLITISIISVYEGIVY 570

  Fly   550 TFFERRLIALCFCVFACYNSWENFQWKSRDF---FSWLALVLILSCFPLL-PLSVGYQNGYLLGA 610
            .||.|....|...:.|.|    .|....|:.   ..|:...::||.|.|. .:.:...|...| |
Yeast   571 GFFHRWTFTLITNILAFY----PFICGVRELSVNILWIITSVLLSTFTLFDAVKIEDLNQIHL-A 630

  Fly   611 GVIVIFTNSFWNSKSRLCYRNHTK---YSNALILLQTILCAYL----HSNGIN------IPIPLK 662
            |:::|. ::|:     ..|:.|::   |:.|:..:|..|.|.:    |.:.|:      :|...:
Yeast   631 GLLIIL-SAFY-----ALYKIHSRINSYTRAIFAIQISLVAAMLAVTHRSVISLQLRQGLPRESQ 689

  Fly   663 LASW-LYLVYAFASILL---SKESRLDLRLAQIGFNLGSLYATLCTSYEAVFVQLLT------IE 717
            :|.| ::.|..|...:|   ...:...:||..|.......:..|..|:|::|..|.|      ||
Yeast   690 VAGWIIFFVSLFVMPILHYRKPNNDYKVRLLIIYLTFAPSFIILTISFESLFYFLFTSYMVQWIE 754

  Fly   718 LNISLRAQSARAERS---VLR---LAFTLLLYTFFSLFGSGNIASISSFDPNIARCYLSHFAPFV 776
            :...::....:.:.:   |||   :.|.||...|   ||:||:||||||........|..|.||:
Yeast   755 IENKIKEMKTQKDENWLQVLRVSVIGFFLLQVAF---FGTGNVASISSFSLESVCRLLPIFDPFL 816

  Fly   777 IMGLVLLKLLVPVVLIMSVIYANSEFVRQHEEQIFICLLLICDVMGLNFLFLVRNQGSWLDIGTS 841
            :..|::|||::|..|:.:.:...:..:...:..|...::.:.|::.|||.:|:|.:|||||||.:
Yeast   817 MGALLMLKLIIPYGLLSTCLGILNLKLNFKDYTISSLIISMSDILSLNFFYLLRTEGSWLDIGIT 881

  Fly   842 ISHFVIMEVTTLVMLVIFYTAKQLLR 867
            ||::.:..:::|.||::......||:
Yeast   882 ISNYCLAILSSLFMLILEVLGHVLLK 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	103/269 (38%)
		GPI_EPT_1	42..335	CDD:293744	117/309 (38%)
		PigN	421..834	CDD:282796	110/452 (24%)
MCD4	NP_012756.1	GPI_EPT_1	46..353	CDD:293744	117/308 (38%)
MCD4	NP_012756.1	PigN	443..874	CDD:398585	110/452 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346533
Domainoid	1	1.000	96	1.000	Domainoid score	I1638
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6330
Inparanoid	1	1.050	366	1.000	Inparanoid score	I369
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoFinder	1	1.000	-	-		FOG0004928
OrthoInspector	1	1.000	-	-		otm46576
orthoMCL	1	0.900	-	-		OOG6_103930
Panther	1	1.100	-	-	LDO	PTHR12250
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R687
SonicParanoid	1	1.000	-	-		X2480
TreeFam	1	0.960	-	-
	16	15.740