DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and LAS21

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_012473.1	Gene:	LAS21 / 853384	SGDID:	S000003598	Length:	830	Species:	Saccharomyces cerevisiae

Alignment Length:	995	Identity:	198/995 - (19%)
Similarity:	328/995 - (32%)	Gaps:	344/995 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IAYALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEP----------PANRLVLIVTDGFR 57
            ::.|.::.:||.  ||..:.|..|:||::.|        :|          |..:||.::.|..|
Yeast     9 LSCAQLLAILLF--IFAFFPRKIVLTGISKQ--------DPDQDRDLQRDRPFQKLVFVIIDALR 63

  Fly    58 ADSFFEENCRYVPNLRKIFLREGVVG--VSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPI 120
            :|..|:....:..|:.: :|..|...  .|....||.|.|...::..|             |.|.
Yeast    64 SDFLFDSQISHFNNVHQ-WLNTGEAWGYTSFANPPTVTLPRLKSITTG-------------STPS 114

  Fly   121 DFDTVFNRSSQTYAWGANDV------LNVFSHVSNGGEINLRFYNHD----------LDFS-PGY 168
            ..|.:.|.:...   .:||:      |..|...:|    .:||...|          .||: |.:
Yeast   115 FIDLLLNVAQDI---DSNDLSEHDSWLQQFIQHNN----TIRFMGDDTWLKLFPQQWFDFADPTH 172

  Fly   169 DAYEED------------------EWVFKRVKLLLQQKREALQRAQNVVFFLHLLGLDTAGHVHK 215
            ..:..|                  ||                  ||..|..||.||||..||...
Yeast   173 SFFVSDFTQVDNNVTRNLPGKLFQEW------------------AQWDVAILHYLGLDHIGHKDG 219

  Fly   216 PGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGMTDSGAHGSGSPHETDTPFMLWG 280
            |.:.......::.:..:.:||.|......|..|...:..||||.:.|.||..|..||....:...
Yeast   220 PHSKFMAAKHQEMDSILKSIYDEVLEHEDDDDTLICVLGDHGMNELGNHGGSSAGETSAGLLFLS 284

  Fly   281 AG-ASRAVPKPGGRTFMPNNEGPAMPLHELE---QAQLTPLMSALLGLAPPMNNFGKLPLGYLNV 341
            .. |..|.|:......:|.|..|......||   |..:.|.::||.|:..|||:.|.:...:
Yeast   285 PKLAQFARPESQVNYTLPINASPDWNFQYLETVQQIDIVPTIAALFGMPIPMNSVGIIIPDF--- 346

  Fly   342 SKEYEAMAAHVNALQLLEQYVALQKQH------KKGFFADILLEYDVLNAEAI--KRY--KDTIV 396
                         ||||...:|..|::      ......::.|  |...||.|  |.|  ::|:.
Yeast   347 -------------LQLLPNKLASMKENFMHLWKLSDHHGEVAL--DDFTAEDIYTKMYTIQETLT 396

  Fly   397 QLQKKREYSLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFLGWMFY----IYRLLSRNRA 457
            :......|.|                              .|..|:|::..    ||.||..:..
Yeast   397 KSATNYNYPL------------------------------LTLAFVGFLIITIIAIYVLLRYSGP 431

  Fly   458 SKVELVLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFVWLKALQPWNIN-FSSSP 521
            ...:|         |||.:|.::|.||.    |.....|.::...:.:|.     |.:. ||:.|
Yeast   432 DFWQL---------RVSSLSVLLVSIIL----GVSTFASSFIEEEHQLWW-----WIVTAFSAVP 478

  Fly   522 ASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIALCFCVFACYNSWENFQWKSRDFF----- 581
            ...|.:..|....|  .:::||...:.|                    |.|   ..:.|.
Yeast   479 LFVYRLNVLIIVRW--FIMMACVRSIKF--------------------WNN---SGQKFIYSNVM 518

  Fly   582 --------SWLALVLILSCFPLLPLSVGYQNGYLLGAGVIVIFTNSFWNSKSRLCYRNHTKYSNA 638
                    ||...:.:|:...|:..|.|:|..:.:...::|           .||:
Yeast   519 SNLLNQNPSWKWCLNMLTFLVLIMASAGFQVLHFIVTTILV-----------GLCF--------- 563

  Fly   639 LILLQTILCAYLHSNGINIPIPLKLASWLYLV-----------------YAFASILLSKESRLDL 686
                 |...::...||....|||.:...|..:                 .|:|.:::|:.....|
Yeast   564 -----TYKISWEIVNGNQAEIPLFMHDLLAKIDFAPTESNLIVLARVFFQAWAIVVISRLVLTKL 623

  Fly   687 RLAQIGFNLGSL--YATLCTSYEA---------VFVQLLTIELNISLRAQSARAERSVLRLAFTL 740
            ::....:.:..:  |.|:...::.         || |:|..::....:.....:..|..::.|:.
Yeast   624 KVLNKNYLIKDMKVYITILLMFQTSSQNIGQFLVF-QILESQIFYFFQNIPTASLTSTSKIYFSN 687

  Fly   741 LL------YTFFSLFGSGNIASIS--------SFDPNIARCY-------LSHFAPFVIMGLVLLK 784
            |:      :|||...|:.:|::|.        |.|.||   |       :::|||.:...:
Yeast   688 LVSLILQNFTFFQFGGTNSISTIDLGNAYHGVSSDYNI---YVVGILMSVANFAPAIYWSM---- 745

  Fly   785 LLVPVVLIMSVIYANSEFVRQHEEQIFI---------------CLLLICDV-------------- 820
                  |..|:.||:  ...|.:.|.||               ||:..|.|
Yeast   746 ------LPWSINYAS--IPAQVKLQTFIRSKLPAFTYHCIFGTCLMTACVVLRFHLFIWSVFSPK 802

  Fly   821 ----MGLNFLFLVRNQGSWL 836
                :|.||:..:.|  .||
Yeast   803 LCYFLGWNFVMGLLN--GWL 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	66/301 (22%)
		GPI_EPT_1	42..335	CDD:293744	79/343 (23%)
		PigN	421..834	CDD:282796	91/512 (18%)
LAS21	NP_012473.1	Npp1	18..610	CDD:224441	152/756 (20%)
LAS21	NP_012473.1	GPI_EPT_2	48..343	CDD:293748	78/333 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810