DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and PIGO

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_116023.2	Gene:	PIGO / 84720	HGNCID:	23215	Length:	1089	Species:	Homo sapiens

Alignment Length:	712	Identity:	147/712 - (20%)
Similarity:	231/712 - (32%)	Gaps:	219/712 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIAYALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPA--------------------- 45
            |:.:.....:.|..|.|       ::|.|....|....  |||.
Human    12 WVCFLFYAGIALFTSGF-------LLTRLELTNHSSCQ--EPPGPGSLPWGSQGKPGACWMASRF 67

  Fly    46 NRLVLIVTDGFRADSFFEENCRYVPNLRKIFLREGVVGV-------SRTRVPTETRPGHITLIAG 103
            :|:||::.|..|.| |.:....:||       ||..|.:       |..|: .|.:|.|..|...
Human    68 SRVVLVLIDALRFD-FAQPQHSHVP-------REPPVSLPFLGKLSSLQRI-LEIQPHHARLYRS 123

  Fly   104 LYEDPSAVLRGWK-----SNPIDFDTVFNRSSQTYAWGANDVLNVFSHVSNGGEINLRFYNHDL- 162
            ..:.|:..::..|     |.|...|...|.:|...   ..|  |:...:::.|. .:.|...|.
Human   124 QVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAI---VED--NLIKQLTSAGR-RVVFMGDDTW 182

  Fly   163 -DFSPG---------------------------YDAYEEDEWVFKRVKLLLQQKREALQRAQNVV 199
             |..||                           |...:..||                     .|
Human   183 KDLFPGAFSKAFFFPSFNVRDLDTVDNGILEHLYPTMDSGEW---------------------DV 226

  Fly   200 FFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGMTDSGAH 264
            ...|.||:|..||.|.|..|:..:.|.:.::.:..:.:..|     ..|..::..|||||.:|.|
Human   227 LIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLE-----NDTLLVVAGDHGMTTNGDH 286

  Fly   265 GSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNEGPAMPLHELE---QAQLTPLMSALLGLAP 326
            |..|..|......|                :.|....|:.|..|.|   |..|.|.::.||||..
Human   287 GGDSELEVSAALFL----------------YSPTAVFPSTPPEEPEVIPQVSLVPTLALLLGLPI 335

  Fly   327 PMNNFGKLPLGYLNVSKEYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAEAIKRY 391
            |..|.|::.....:..::.:   .|.:|   |.|..||.                 |||:.:.|:
Human   336 PFGNIGEVMAELFSGGEDSQ---PHSSA---LAQASALH-----------------LNAQQVSRF 377

  Fly   392 KDTIVQLQKKREYSLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFLGWMFYIYRLLSRNR 456
            ..|         ||......|......|:.            |.|..|....|      ||...:
Human   378 LHT---------YSAATQDLQAKELHQLQN------------LFSKASADYQW------LLQSPK 415

  Fly   457 ASKVEL-----VLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFVWLKALQPWNIN 516
            .::..|     .|::..:..|...:.|.....:..::.||.|     |....|:.|.|.| |.|
Human   416 GAEATLPTVIAELQQFLRGARAMCIESWARFSLVRMAGGTAL-----LAASCFICLLASQ-WAI- 473

  Fly   517 FSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIALCFCVFACYNSWENFQWKSRDFF 581
               ||...:....|....|.||..||.|.|:  ...|.:|..:.....|..:|:..|.||:  :.
Human   474 ---SPGFPFCPLLLTPVAWGLVGAIAYAGLL--GTIELKLDLVLLGAVAAVSSFLPFLWKA--WA 531

  Fly   582 SWLALVLILSCFP---------LLPLSVGYQNG----------YLLGAGVIVIFTNSFWNSK 624
            .|.:...:.:.||         |..|:|.:.:.          :|||:.::::.....|..:
Human   532 GWGSKRPLATLFPIPGPVLLLLLFRLAVFFSDSFVVAEARATPFLLGSFILLLVVQLHWEGQ 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	64/316 (20%)
		GPI_EPT_1	42..335	CDD:293744	78/357 (22%)
		PigN	421..834	CDD:282796	47/228 (21%)
PIGO	NP_116023.2	Npp1	42..>299	CDD:224441	62/299 (21%)
PIGO	NP_116023.2	GPI_EPT_3	65..344	CDD:293747	75/335 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810