DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and pign

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001297009.1	Gene:	pign / 556797	ZFINID:	ZDB-GENE-080204-114	Length:	932	Species:	Danio rerio

Alignment Length:	934	Identity:	329/934 - (35%)
Similarity:	495/934 - (52%)	Gaps:	96/934 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRADSFF---EENCRY 68
            |:|||:....||.|||.||::.|:|||:    ..|.|||.||||.|.||.||||.|   :.....
Zfish    11 LIVHVVFFLCIFDIYFTSPLVHGMTPQR----VSLPPPAKRLVLFVADGLRADSLFKPDDSGTSR 71

  Fly    69 VPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVFNRSSQTY 133
            .|.||.:....|..|||.||||||:||||:.||||.|||.|||.:|||.||::||:|||.|..|:
Zfish    72 APYLRSVIEEGGTWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSVFNESRYTW 136

  Fly   134 AWGANDVLNVFSHVSNGGEINLRFYNHDLDFSPGYDAYEEDEWVFKRVKLLLQQKR------EAL 192
            .||:.|:|.:|:..:.|..:....|..:.:.....||...|.|||..||..|...:      :.|
Zfish   137 CWGSPDILPMFAKGATGDHVYTHTYPPEREDFASTDASRLDTWVFDEVKDFLTAAKSNETLLKKL 201

  Fly   193 QRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVF-PDKRTAYLLTADH 256
            ...|| ||||||||:||.||.|:|.:.:....:...:.||..|....:..: .|.:|||:.|:||
Zfish   202 HEEQN-VFFLHLLGIDTNGHAHRPMSKECLENIGLVDAGVADIVTVMDDFYGHDGKTAYVFTSDH 265

  Fly   257 GMTDSGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNEGPAMPLH-----ELEQAQLTP 316
            |||:.|:||:|.|.||.||.::||||..:|..:...:  ..:|......|.     ::.||.:.|
Zfish   266 GMTNWGSHGAGHPSETLTPLVVWGAGVQKAQWETSQK--YEDNYLKEWGLESYRRVDVNQADIAP 328

  Fly   317 LMSALLGLAPPMNNFGKLPLGYLNVSKEYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEY- 380
            |||:|:|:..|:|:.|.|||.|||.|:.::|.:.:.||:|:|||:.....|.|:...:.:...|
Zfish   329 LMSSLIGIPFPLNSVGVLPLSYLNNSQHFKAESMYANAIQILEQFRVKLAQKKETTISFLFTPYQ 393

  Fly   381 ---DVLNAEAIKRYKDTIVQLQKKREYSLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFL 442
               |....:.|::.:|.|    :|..:...|...:.:::||:||:.|||.|.|..|..|....|:
Zfish   394 PLTDSKQVDFIRQARDLI----QKGRFDEAIVYCKDLIAQAMEGLSYYHTYDRLFLGSSVVLGFI 454

  Fly   443 GWMFYIYRLLSRNRAS------KVELVLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLL 501
            ||..|:...:.:..||      ...:|.||   ::....:...:::.:.||.|.:|.....|.|:
Zfish   455 GWTSYVVLYILKTHASLRKPPTNTSMVTER---LLGWGFLCVGLLMALFLLVQSSPWSYYIYSLM 516

  Fly   502 PYFVWLKALQPWNINFSSSPASAYSVPALQ-TSMWQLVLLIACA-ELMVFTFFERRLIALCFCVF 564
            |..||...|:    .|.:......|:|:|. |..:...:|:|.. ||:|.:||.|.:::|...|.
Zfish   517 PVAVWYAVLK----EFKTLVGLVRSIPSLPLTKCFGYFVLVAFGIELLVMSFFYRAMLSLGLVVL 577

  Fly   565 ACYNSWENFQWKSR-DFFSWLALVLILSCFPLLPLSVGYQN--GYLLGAGVIVIFTNS--FWNS- 623
            |.:.....|..|:: ...||....|.|:.|||||: ||.:.  .|::.||.:::|.:|  .|:|
Zfish   578 ALWPVVSGFYTKAKFKSLSWTLSCLSLAVFPLLPV-VGREPNINYVISAGGLILFNSSSFLWSSW 641

  Fly   624 -KSRLCYRNHTKYSNALILLQTILCAY----LHSN---GINIPIPLKLASWLYLVYAFASILLSK 680
             .|.|..|:...:  ...::|..||||    .||:   ...:||..:|.||..||.:|...|||
Zfish   642 RDSPLMRRDRQLF--IFQMVQVALCAYTLTSTHSSLQLKQGLPIFNQLVSWSTLVSSFLIPLLS- 703

  Fly   681 ESRLDLRLAQIGFNLGSLYATLCTSYEAVFVQLLT--------IELN-ISLRAQSARAERSV--- 733
            .:||..||..|..:|..:|..|.|.:||:|..:|:        ||.. :|.:..|.|.|.|.
Zfish   704 STRLFHRLLSILMSLTCVYLLLSTGHEALFPLMLSWLMLAWIHIEQEAMSRQGSSNRNELSCIDF 768

  Fly   734 ----------------LRLAFTLLLYTFFSLFGSGNIASISSFDPNIARCYLSHFAPFVIMGLVL 782
                            :|.::..:.:...:.||.||||||:||||....|:|:.|.||::.||::
Zfish   769 AENIDITKVRQLRLDDIRKSYFFVFFIIIAFFGCGNIASINSFDPASVYCFLTVFNPFIMGGLLM 833

  Fly   783 LKLLVPVVLIMSVIYANSEFVRQHEEQIFICLLLICDVMGLNFLFLVRNQGSWLDIGTSISHFVI 847
            .|:|:|.|::|....:.....:.....:|:.:|:|.|:|.|:|.|||::.||||||||||||:||
Zfish   834 WKVLIPFVIVMCTFESIQVSTQLSSRSLFLIVLVISDLMALHFFFLVKDYGSWLDIGTSISHYVI 898

  Fly   848 -MEVTTLVMLVI----FYTAKQLL 866
             |.:|..:||:.    ..|:|::|
Zfish   899 VMSMTIFLMLLSVMTHILTSKKIL 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	115/264 (44%)
		GPI_EPT_1	42..335	CDD:293744	127/307 (41%)
		PigN	421..834	CDD:282796	139/462 (30%)
pign	NP_001297009.1	Npp1	11..>282	CDD:224441	122/275 (44%)
		GPI_EPT_1	42..347	CDD:293744	127/307 (41%)
		PigN	433..885	CDD:282796	139/462 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596000
Domainoid	1	1.000	166	1.000	Domainoid score	I3840
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6330
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1452
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	1	1.000	-	-		FOG0004928
OrthoInspector	1	1.000	-	-		otm25781
orthoMCL	1	0.900	-	-		OOG6_103930
Panther	1	1.100	-	-	LDO	PTHR12250
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R687
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940