Protein Alignment PIG-N and PIGG

DIOPT Version :10

• Sequence 1: NP_610549.1
• Gene: PIG-N / 36049
• FlyBaseID: FBgn0033479
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001120650.1
• Gene: PIGG / 54872
• HGNCID: 25985
• Length: 983
• Species: Homo sapiens
• Alignment Length: 1064
• Identity: 209/1064 - (19%)
• Similarity: 356/1064 - (33%)
• Gaps: 303/1064 - (28%)

  Fly     7 LVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPA-------------------NRLVLIV 52
            |.:.|.|.|     :|.:||.:....:     :|.||||                   :::|:::
Human    18 LGIAVFLRG-----FFPAPVRSSARAE-----HGAEPPAPEPSAGASSNWTTLPPPLFSKVVIVL 72

  Fly    53 TDGFRADSFF-EENCRYVPNLRKIFLREGVVG--VSRTRVPTETRPGHITLIAGLYEDPSAVLRG 114
            .|..|.|..| .:..:::| .....:.:|...  |:..:.||.|.|....|:.|.......|:|.
Human    73 IDALRDDFVFGSKGVKFMP-YTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRN 136

  Fly   115 WKSNPIDFDTVFNRSSQTYAWGANDVLNVFSHVSNGGEINLR-FYNH--DLDFSPGY---DAYEE 173
            ..|..:..|:|..   |..|.|...|.       .|.|..:: |..|  :.|.:..:   |..|.
Human   137 LNSPALLEDSVIR---QAKAAGKRIVF-------YGDETWVKLFPKHFVEYDGTTSFFVSDYTEV 191

  Fly   174 DEWVFKRVKLLLQQKREALQRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIY-- 236
            |..|.:.:.       :.|:|....:..||.||||..||:..|.:|...:.|.:.:..:..|:
Human   192 DNNVTRHLD-------KVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTS 249

  Fly   237 -QEFERVFPDKRTAYLLTADHGMTDSGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNE 300
             |..||..| .....:|..||||:::|:||:.|..|.:||.:|..:...|   |||....
Human   250 LQSKERETP-LPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFER---KPGDIRH----- 305

  Fly   301 GPAMPLHELEQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEYEAMA-AHVNALQL------- 357
                |.| ::|..:...::..|||..|.::.|.|....:......|.:. .|:|.:||
Human   306 ----PKH-VQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQEN 365

  Fly   358 ---------LEQYVALQKQHKKGFFADILLEYDVLNAEAIKRYKDTIVQLQKK--REYSLCIDKS 411
                     .||:...::.|  |.:..:.||         :::.:.:..|..|  |:|...:...
Human   366 VPSYEKDPGFEQFKMSERLH--GNWIRLYLE---------EKHSEVLFNLGSKVLRQYLDALKTL 419

  Fly   412 QVIMSQALEGIDYYHGYYRRVLLLSTTSTFLGWMFYIYRLLSRNRASKVELVLERSNK-----IV 471
            .:.:|..:...|.|......|::|...:..|   ..:.:.|.|    |.||.:..|:.     ..
Human   420 SLSLSAQVAQYDIYSMMVGTVVVLEVLTLLL---LSVPQALRR----KAELEVPLSSPGFSLLFY 477

  Fly   472 RVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFVWLKALQPWNINFSSSPASAYSV--------- 527
            .|.:|.|.:.:|:|..::.:          .||..|..|....:...:|......|
Human   478 LVILVLSAVHVIVCTSAESS----------CYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVG 532

  Fly   528 -------PALQTSMW---QLVLLIACA----ELMVFTFFERR-----LIALCFCVFACYNSWENF 573
                   |...:|.|   .|::|:..|    .|...:|.|..     .:....|:.....::.|:
Human   533 GNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNY 597

  Fly   574 -----------------------QWKS----------------------RDFFSWLALV---LIL 590
                                   .|:.                      |....|:.|.   |||
Human   598 FLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLIL 662

  Fly   591 SCFPLLPL--SVGYQNGYLLGAGVIVIFTNSFWNSKSRLCYRNHTKYSNALILLQTILCAYLHSN 653
            :|..||..  ..|.|..:....|        .|.:.|     :|....:.|..|..::...|...
Human   663 ACCRLLRSLNQTGVQWAHRPDLG--------HWLTSS-----DHKAELSVLAALSLLVVFVLVQR 714

  Fly   654 GINIPIPLKLASWLYLVYAFASILLS------------KESRLDLRLAQIGFNLGSLYA------ 700
            |.:......||..|..||.:.:.:.|            .:..::.|...: |.||.|:.
Human   715 GCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYV-FVLGILFTGTKDLL 778

  Fly   701 ---TLCTSYEAVFVQLLTIELNISLRAQSARAERSVLRLAFTLLLYTFFSLF------------- 749
               .:...::...|.|..|...:.|.|.......::..|||:||:.|..:.|
Human   779 KSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEIT 843

  Fly   750 ---------------GSGNIASISSFDPNIARCYLSHFAPFVIMGLVLLKLLV--PVVLIMSV-I 796
                           .|.|||::.                 :..|.|.|...|  |.||:.:. .
Human   844 VMHYWFGQAFFYFQGNSNNIATVD-----------------ISAGFVGLDTYVEIPAVLLTAFGT 891

  Fly   797 YANSEFVRQHEEQIF--------------ICLLLICDVMGLNFLFLVRNQGSWLDIGTSISHFVI 847
            ||.......|.....              .|..|||.:....::.||.:....|.|.:..|..::
Human   892 YAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLL 956

  Fly   848 MEVTTLVM---LVIFYTAKQLLRV 868
            .|...|::   :.:|:||....|:
Human   957 YEGMHLLITAAVCVFFTAMDQTRL 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	GPI_EPT_1	42..335	CDD:293744	79/323 (24%)
		PigN	420..834	CDD:461508	96/562 (17%)
PIGG	NP_001120650.1	GPI_EPT_2	62..335	CDD:293748	75/304 (25%)
		PIGO_PIGG	<803..965	CDD:437148	34/178 (19%)