DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and ENPP2

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_006716647.1	Gene:	ENPP2 / 5168	HGNCID:	3357	Length:	940	Species:	Homo sapiens

Alignment Length:	690	Identity:	128/690 - (18%)
Similarity:	206/690 - (29%)	Gaps:	226/690 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LEPPANRLVLIVTDGFRADSFFEENCRYVPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLY 105
            :.||   |::...||||| |:.::..:.:||:.|:..........|...||:|.|...||..|||
Human   162 VRPP---LIIFSVDGFRA-SYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLY 222

  Fly   106 EDPSAVLRGWKSNPIDFDTVFN---RSSQTYAWGANDVL------------NVFSHVSNGGEINL 155
            .:...::.....:|: ||..|:   |....:.|.....|            ..|..|....|..:
Human   223 PESHGIVGNSMYDPV-FDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRI 286

  Fly   156 ------------------RFYNHDLDFS--------PGYDAYEEDEWVFKRVKLLLQQKRE---- 190
                              .||:...|||        |...:|.......||.|..:..||.
Human   287 LTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEESSYGSPFTPAKRPKRKVAPKRRQERP 351

  Fly   191 -----------------------------------------------ALQRAQNVVF-------- 200
                                                           .|.|..||:|
Human   352 VAPPKKRRRKIHRMDHYAAETRQDKMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMED 416

  Fly   201 -------FL--HLLGLD-------TAGHVHKPGAPKFRRTLEKTEKGVYA---------IYQEFE 240
                   ||  :|..:|       |.|.:..    ||....:...|.:.|         .::.:.
Human   417 VTCDRTEFLSNYLTNVDDITLVPGTLGRIRS----KFSNNAKYDPKAIIANLTCKKPDQHFKPYL 477

  Fly   241 RVFPDKRTAYL----LTADHGMTDSGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNEG 301
            :....||..|.    :...|.:.:...|.:..|.:              ...||.|:.|...:.|
Human   478 KQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLD--------------VYKKPSGKCFFQGDHG 528

  Fly   302 PAMPLHEL--------------------EQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEYE 346
            ....::.:                    |..:|..:|..||||.|..||.....|.:|..:..:.
Human   529 FDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFR 593

  Fly   347 AMAAHVNALQLLEQYVALQKQHKKGFFADILLE----YDVLN----------AEAIK------RY 391
            ...............:.||.....|...|..:|    .|.||          ||..|      ..
Human   594 PTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEAETRKFRGSRNEN 658

  Fly   392 KDTI-VQLQKKREYSLCIDKSQVIMS---QALEGIDYYHGYYRRVLLLSTTSTFLGWMFYIYRLL 452
            |:.| ...:.::|..|...:..|:..   ..|...|:..| |..:.|:..      |..|
Human   659 KENINGNFEPRKERHLLYGRPAVLYRTRYDILYHTDFESG-YSEIFLMPL------WTSY----- 711

  Fly   453 SRNRASKVELVLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFVWLKALQPWNINF 517
            :.::.::|..|.:.....||..:..|......||..:... .:|:..|.|.::
Human   712 TVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDK-QMSYGFLFPPYL------------ 763

  Fly   518 SSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLI 557
            ||||.:.|.. .|.|:|    :.:..|...|:.:|:|.|:
Human   764 SSSPEAKYDA-FLVTNM----VPMYPAFKRVWNYFQRVLV 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	63/352 (18%)
		GPI_EPT_1	42..335	CDD:293744	80/441 (18%)
		PigN	421..834	CDD:282796	29/137 (21%)
ENPP2	XP_006716647.1	SO	55..98	CDD:197571
		SO	99..142	CDD:197571
		Enpp	164..570	CDD:293742	74/428 (17%)
		Phosphodiest	166..530	CDD:279931	68/383 (18%)
		NUC	692..922	CDD:214683	29/137 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810