DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-N and ENPP1

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_006199.2	Gene:	ENPP1 / 5167	HGNCID:	3356	Length:	925	Species:	Homo sapiens

Alignment Length:	425	Identity:	82/425 - (19%)
Similarity:	141/425 - (33%)	Gaps:	139/425 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GLEPPANRLVLIVTDGFRAD------------SFFEENCRYVPNLRKIFLREGVVGVSRTRVPTE 92
            |.|.|..  :|...|||||:            |..::...|..|:|.::             ||:
Human   206 GFETPPT--LLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVY-------------PTK 255

  Fly    93 TRPGHITLIAGLYEDPSAVL-----------------------RGWKSNPIDFDTVF-NRSSQTY 133
            |.|.|.:::.|||.:...::                       ..:|..||.....: ...|.|:
Human   256 TFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTF 320

  Fly   134 AWGANDVLNVFSHVSNGGEIN------LRFYNHDLDFSPGYDAYEEDEWVFKRVKLLLQQKREAL 192
            .|..:||           |||      .:.||..:.|.             :|:..:||..:  |
Human   321 FWPGSDV-----------EINGIFPDIYKMYNGSVPFE-------------ERILAVLQWLQ--L 359

  Fly   193 QRAQNVVFF-LHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADH 256
            .:.:...|: |:|...|::||.:.|.:.:..:.|::.:..|..:....:.:...:....:|.:||
Human   360 PKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDH 424

  Fly   257 GMTDSGA-------------------HGSGSP-HETDTPFMLWG---AGASRAVP--------KP 290
            ||.....                   :|..:. ..:|.|...:.   .|.:|.:.        ||
Human   425 GMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKP 489

  Fly   291 GGRTFMPNNEGPAMPLHELEQAQLTPLMSAL-----LGLAPPMNNF-GKLPLGYLNVSKEYEAMA 349
            ..:.|:|..      ||..:..::.||...|     |.|.|....: |....|..||....:|:
Human   490 YLKHFLPKR------LHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQAL- 547

  Fly   350 AHVNALQLLEQYVALQKQHKKGFFADILLEYDVLN 384
                       :|......|.|..||.....:|.|
Human   548 -----------FVGYGPGFKHGIEADTFENIEVYN 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	53/286 (19%)
		GPI_EPT_1	42..335	CDD:293744	70/372 (19%)
		PigN	421..834	CDD:282796
ENPP1	NP_006199.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Di-leucine motif. /evidence=ECO:0000250\|UniProtKB:P06802	45..52
		SO	104..144	CDD:197571
		SO	145..188	CDD:197571
		Phosphodiesterase. /evidence=ECO:0000250\|UniProtKB:P06802	191..591		82/425 (19%)
		Phosphodiest	212..538	CDD:396300	69/372 (19%)
		Linker. /evidence=ECO:0000250\|UniProtKB:P06802	597..647
		Nuclease. /evidence=ECO:0000250\|UniProtKB:P06802	654..925
		NUC	676..907	CDD:214683
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910