DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and Pigo

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_038966909.1	Gene:	Pigo / 313341	RGDID:	1309498	Length:	1128	Species:	Rattus norvegicus

Alignment Length:	1061	Identity:	218/1061 - (20%)
Similarity:	345/1061 - (32%)	Gaps:	336/1061 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WIAYALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPA--------------------- 45
            |:.:.....:.|..|.|::     ....||.|...    .|||.
  Rat    33 WVCFLFYAGIALFTSGFLL-----TRLELTNQSSC----QEPPGPGSLPWGSQGKPGACWMPSRF 88

  Fly    46 NRLVLIVTDGFRADSFFEENCRYVPNLRKI---FLREGVVGVSRTRVPTETRPGHITLIAGLYED 107
            :|:||::.|..|.| |.:..|.:||....:   ||  |.:| |..|: .|.:|.|..|.....:.
  Rat    89 SRVVLVLIDALRFD-FAQPQCSHVPGEPPVSVPFL--GKLG-SLKRI-LEVQPHHARLYQSQVDP 148

  Fly   108 PSAVLRGWK-----SNPIDFDTVFNRSSQTYAWGANDVLNVFSHVSNGGEINLRFYNHDL--DFS 165
            |:..::..|     |.|...|...|.:|...   ..|  |:...:::.|: .:.|...|.  |..
  Rat   149 PTTTMQRLKALTTGSLPTFIDAGSNFASHAI---VED--NLIKQLTSAGK-RVVFMGDDTWKDLF 207

  Fly   166 PGYDAYEEDEWVFKRVKL---------LLQQKREALQRAQNVVFFLHLLGLDTAGHVHKPGAPKF 221
            ||  |:.: .:.|....:         :|:.....:......|...|.||:|..||.|.|..|:.
  Rat   208 PG--AFSQ-AFFFSSFNVRDLHTVDNGILEHLYPTMDSGAWDVLIAHFLGVDHCGHKHGPHHPEM 269

  Fly   222 RRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGMTDSGAHGSGSPHETDTPFMLWGAGASRA 286
            .:.|.:.::.:..:.:..|     ..|..::..|||||.:|.||..|..|......|
  Rat   270 AKKLSQMDQVIQGLIERLE-----NDTLLVVAGDHGMTMNGDHGGDSELEVSAALFL-------- 321

  Fly   287 VPKPGGRTFMPNNEGPAMPLHELE---QAQLTPLMSALLGLAPPMNNFGKLPL-----GYLNVSK 343
                    :.|....|::|..|.|   |..|.|.::.||||..|..|.|::..     |....|.
  Rat   322 --------YSPTVLFPSVPPEEPEVIPQISLVPTLALLLGLPIPFGNIGEVMAELFSGGSGGGSS 378

  Fly   344 EYEAMAAH--------VNALQLLEQYV---------ALQKQHKKGFFADILLEYDVLNAEAIKRY 391
            ..:..|:|        |:||.:..|.|         |.|..|.|.     |.....|.::|..||
  Rat   379 RGDGDASHPDSPALAQVSALYINAQQVSRFLHTYSAATQDLHVKE-----LRRLQELFSKASARY 438

  Fly   392 KDTIVQLQKKREYSLCIDKSQVIMSQALEG----------------------------------- 421
            :..   ||..||....:........|.|.|
  Rat   439 QHL---LQHPREAEAALSSLTADFQQFLRGARAVCIESWARFSLVRMAGGAALLAAACLLCLLAS 500

  Fly   422 -IDYYHGYYRRVLLLSTTSTFLGWMFYIYRLLSRNRASKVELVLERSNKIVRVSIVSSVI----- 480
             :....|:..|.|||...:..|.|.. :|..:|....||::.|:     :..|:...|::
  Rat   501 QLAVAPGFLFRPLLLIPVAWGLTWTL-LYAGVSVTTGSKLDPVV-----LGAVAAAGSLLPFLWK 559

  Fly   481 --------------------VLIICLLSQGTPLDISF---------YLLLPYFVWLKALQPWN-- 514
                                ||.:.|:...|....||         :||....::|.|...|.
  Rat   560 AWLSWGSKRPLAPLLPVPRPVLALLLIRLATFFSDSFVVAEARATPFLLGSLILFLVAQLHWEGQ 624

  Fly   515 ------INFSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIALCF-C---VFACYNS 569
                  :..|...:||.:.|...:....|:|.|.   |::||    ||..|.. |   ..||.:|
  Rat   625 LLPPKLLTTSRLGSSAPTAPPRHSGTHALLLGIG---LLLFT----RLAGLFHRCPEETPACRSS 682

  Fly   570 WENFQWKSRDFFSWLALVLILSCFPLLPLSVGYQN----GYLLGAGVIVIFTNSFW-----NSKS 625
                        .||:        ||..:..|...    |..:||.|.::.....|     |.||
  Rat   683 ------------PWLS--------PLASMVGGRAKNLWYGACVGALVALLAAVRLWLRRYGNLKS 727

  Fly   626 RLCYRNHTKYSNALILLQTILCAYLHSNGINIPIPLKLASWLYLVYAFASILLSKESRLDLRLAQ 690
            ........::...|::|.|.....|.|....:|..|:      .:.|.||.:|   .|..:.||.
  Rat   728 PEPPVLFVRWGLPLMVLGTAAYWALASGAEEVPPRLR------ALVAGASAVL---PRAVMGLAA 783

  Fly   691 IGFNLGSLYATLCTSYEAVFVQLLTIELNISLRAQSARAERSVLRLAFTLLLYTFFSLFGSGNIA 755
            .|..|                 ||...:.:.::|.:|.:....:...|            ||...
  Rat   784 SGLML-----------------LLWRPVTVLVKAGAATSRTRTILTPF------------SGPPT 819

  Fly   756 SISSFD---PNIARCYLSHF----------APFVI------------MGLVLLKLLVPVVLIMSV 795
            |.:..|   |.|.|.....|          .|..:            |...|:.|..|::|:
  Rat   820 SQADLDYVVPQIYRHMQEEFQGRLERTRAQGPITVAAYQLGSVYSAAMVTALILLAFPLLLL--- 881

  Fly   796 IYANSEFVRQHEEQIFICLLLICDVMGLNFLFL--------VRNQGSWLDIGTSISHFVIMEVTT 852
                      |.|::.:..||:   ...:||.|        |...|.:..:..::|.:|::...|
  Rat   882 ----------HVERVSLVFLLL---FLQSFLLLHLLAAGTPVATPGPFTVMWQAVSAWVLLATQT 933

  Fly   853 LVMLVIFYTA--KQLLRVIPW 871
                  ||:.  :.:...|.|
  Rat   934 ------FYSTGHQPVFSAIHW 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	66/294 (22%)
		GPI_EPT_1	42..335	CDD:293744	80/335 (24%)
		PigN	421..834	CDD:282796	99/536 (18%)
Pigo	XP_038966909.1	GPI_EPT_3	85..365	CDD:293747	77/314 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910