DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-N and Enpp7

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001012484.2	Gene:	Enpp7 / 303729	RGDID:	1359324	Length:	439	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	91/469 - (19%)
Similarity:	148/469 - (31%)	Gaps:	159/469 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HVLLLGSIFVIYFRSPVITG--LTPQKHLLYYGLEPPANRLVLIVTDGFRADSFFEENCRYVPNL 72
            |..:|.|:.::...:.|..|  ...|:|           :|:|:..||||.:  ::::.. .|||
  Rat     3 HSAVLLSVALVILPACVTGGPVQRQQRH-----------KLLLVSFDGFRWN--YDQDVE-TPNL 53

  Fly    73 RKIFLREGVVGVSRTRVP---TETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVFNRSSQTY- 133
            ..: .:|||  .:|...|   |.|.|.|.||:.|.|.:...|:...      |....|:....|
  Rat    54 DSM-AQEGV--KARYMTPAFVTMTSPCHFTLVTGKYIENHGVVHNM------FYNTTNKVRLPYH 109

  Fly   134 ------AWGANDVLNVFSHVSNGGEINLRFYNHDLDFSPGYDAYEEDEWV--FKRVKLLLQQKRE 190
                  .|..|..:.::......|.....|      |.||.:...:.|.|  .::..:|...|.|
  Rat   110 ATLGIQRWWDNGSIPIWITAQRQGLKTGSF------FYPGGNVTYQGEAVTMSRKEGVLHNYKNE 168

  Fly   191 ALQRAQNV-------------VFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERV 242
            ...|| ||             :..|:....|:.||.:.|.:.:.:..:::.::.|..:....:|.
  Rat   169 TEWRA-NVDTVMKWFTEEDVSLVTLYFGEPDSTGHKYGPESQERKDMVKQVDRTVGYLRDSIKRH 232

  Fly   243 FPDKRTAYLLTADHGMTDSGAHGSG------SPHET--DTPFMLWGAGAS-RAVPKPG------- 291
            ........::|:|||||......|.      .|:.|  |..|.|...|.: ..:||.|
  Rat   233 HLTDSLNLIITSDHGMTTVNKKASDLVEFHKFPNFTFRDIEFELLDYGPNGMLIPKEGMLEKVYS 297

  Fly   292 -------------------------------------------GRTFMPNNEG------------ 301
                                                       ||..:..|.|
  Rat   298 VLKDAHPRLHVYKKEDFPKTFHYANNPRITSLLMYSDLGYVIHGRVNVQFNNGEHGFDNQDMDMK 362

  Fly   302 -----------PAMPLHELEQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEYEAMAAHVNAL 355
                       ..:.:...|...:..||..|||:.|..|:                   .|...|
  Rat   363 TIFRAVGPSFKAGLEVEPFESVHVYELMCQLLGIVPEPND-------------------GHPGVL 408

  Fly   356 Q-LLEQYVALQKQH 368
            | :|.....|.:||
  Rat   409 QPMLRSGSPLSRQH 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	62/281 (22%)
		GPI_EPT_1	42..335	CDD:293744	77/399 (19%)
		PigN	421..834	CDD:282796
Enpp7	NP_001012484.2	Enpp	30..395	CDD:293742	74/394 (19%)
Enpp7	NP_001012484.2	Required for enzyme activity. /evidence=ECO:0000250\|UniProtKB:Q6UWV6	71..77		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810