DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-N and Enpp4

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_006244660.1	Gene:	Enpp4 / 301261	RGDID:	1308689	Length:	605	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	101/449 - (22%)
Similarity:	153/449 - (34%)	Gaps:	161/449 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVHVLLLGSIFVIYFRSPV---ITGLTPQKHLL---YYGL---------EPPANRLVLIVTDGFR 57
            |:|:.....|:|:.....|   ::.:...|.|:   ::||         ...|.:|:|:..||||
  Rat   124 VLHLCSWHGIYVLDITKGVPAAVSNVFNMKLLVILSFWGLVAGYRGNSSYSSAPQLLLVSFDGFR 188

  Fly    58 ADSFFEENCRYVPNLRKIFLREGVVGVSRTR--VPTETRPGHITLIAGLYEDPSAVLRG------ 114
            ||..   |...:|:|:. |::|||: |...:  ..|:|.|.|.:::.||||:...::..
  Rat   189 ADYL---NNYDLPHLQN-FIKEGVL-VEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDDV 248

  Fly   115 ----------------------WKSNPIDFDTVFNRSSQTYAWGANDV----------LNVFSHV 147
                                  |.:|.:.    .||||....|...||          :|..|.|
  Rat   249 TKKHFSESNDKDPFWWNGAVPIWVTNQLQ----ENRSSAAAMWPGTDVSIHNVTPSYFMNYSSSV 309

  Fly   148 SNGGEIN-----LRFYNHDLDFS---------PGYDAYEEDEWVFKRV---------KLLLQQKR 189
            .....:|     |...|..:.|:         .|:....||::..:||         .|:.:.|.
  Rat   310 PFEERLNNVATWLSSSNPPVTFATLYWEEPDVSGHKYGPEDKFNMRRVLKEVDGLIGDLVQKLKA 374

  Fly   190 EALQRAQNVVFFL----------HLLGLDTA-GHVH------KPGA---PKFRRTLEKTEK---- 230
            ..|..:.||:...          ..:.|||. .|..      .|.|   ||...| |...|
  Rat   375 LGLWESLNVIITSDHGMAQCSENRRIYLDTCINHSDYSVIDLTPVAAILPKINVT-EVYNKLKHC 438

  Fly   231 ----GVY---AI-----YQEFERVFPDKRTAYLLTADHGMTDS--------GAHGSGSPHETDTP 275
                .||   ||     ||..:|:.|     .||.||.|.|.:        |.||..:...:..|
  Rat   439 NPHMTVYLKEAIPNRFYYQHSDRIQP-----ILLVADEGWTIALNTSSSKLGDHGYDNSLPSMHP 498

  Fly   276 FMLWGAGASRAVPKPGGRTFMPNNEGPAM----PLHELEQAQLTPLMSALLGLAPPMNN 330
            |:.                    ..|||.    ....:....:.|:|..:|||.|..||
  Rat   499 FLA--------------------AHGPAFRKGYRQSTINTVDIYPMMCYILGLKPHPNN 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	85/376 (23%)
		GPI_EPT_1	42..335	CDD:293744	92/400 (23%)
		PigN	421..834	CDD:282796
Enpp4	XP_006244660.1	Enpp	177..530	CDD:293742	85/387 (22%)
Enpp4	XP_006244660.1	Phosphodiest	179..490	CDD:279931	78/325 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810