DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and its8

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_595248.1	Gene:	its8 / 2541199	PomBaseID:	SPBC839.08c	Length:	935	Species:	Schizosaccharomyces pombe

Alignment Length:	990	Identity:	281/990 - (28%)
Similarity:	444/990 - (44%)	Gaps:	191/990 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRADSFF--------- 62
            ::.||:.|.|||.|||.:|:|.|:..     |...|.||.||.|||.||.|.|...
pombe    10 ILFHVVFLKSIFDIYFVTPLIHGMKQ-----YSAGEAPAKRLFLIVGDGLRPDKLLQPHSEKVIG 69

  Fly    63 EENCRYVPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVFN 127
            ||.....|.||.|....|..|||.||||||:||||:.||||.|||.|||.:|||.||::||:|||
pombe    70 EEQTYAAPFLRSIIQNNGTFGVSHTRVPTESRPGHVALIAGFYEDVSAVTKGWKKNPVNFDSVFN 134

  Fly   128 RSSQTYAWGANDVLNVFSH-VSNGGEINLRFYNHDL-DFSPGYDAYEEDEWVFKRVKLLLQQKRE 190
            :|..||::|:.|:|.:||. .|:...::...|:.:| |||.  :....|||||.|:..||.|..|
pombe   135 QSRHTYSFGSEDILPMFSEGASDPSRVDTFMYSSELEDFSS--NGIVLDEWVFDRLDELLAQSLE 197

  Fly   191 ------ALQRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVF-PDKRT 248
                  .|.| ..:||||||||:||.||...|.:.::...::..:..:..:..:....: .|..:
pombe   198 DKELWDMLHR-DKIVFFLHLLGIDTIGHNKHPDSVEYVENIQYIDGKIQELVDKMNNYYNNDGAS 261

  Fly   249 AYLLTADHGMTDSGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPN--NEGPAMPLH---- 307
            :::.||||||:|.|:||.|:...|.||.:.||||    :..|   |...|  ::..::|.:
pombe   262 SWVFTADHGMSDFGSHGDGNLDNTRTPIIAWGAG----IQSP---THEKNYGHDEYSLPWNLTEI 319

  Fly   308 ---ELEQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEYEAMAAHVNALQLLEQY--VALQKQ 367
               :::||.:..|||.|:||..|:|:.|::||.||:.|...:|..|.:|||::.|||  .:..|.
pombe   320 KRIDIQQADIAALMSYLVGLNFPVNSVGQIPLDYLDCSSRRKAEVALMNALEIGEQYNLKSASKD 384

  Fly   368 HKKGFFADI--LLEYDVLNAEAIKRYKDTIVQLQKKREYSLCIDKSQVIMSQALEGIDYYHGYYR 430
            ....||...  |..|..:.|..   |...|..:: ..||.:.|:.........|.|:.|...|..
pombe   385 QTSIFFRPYSPLRNYTEVQASF---YNSVIADIE-SGEYEIAIEHCFHFSQTVLSGLRYLQRYDW 445

  Fly   431 RVLLLSTTSTFLGWMFYIYRLLSRNRASKVELVLERSNKIVR-VSIVSSVI----VLIICLLSQG 490
            .:|.......:|.|:.|:...:       ..|.:|.|:|||: ||:|..|.    .|:||
pombe   446 LLLRSIVFFGYLSWIGYVICFV-------FSLNIEPSSKIVKPVSVVKRVAFNIPFLLIC----- 498

  Fly   491 TPLDISFYLLLPYFVWLKALQPWNINFSSSPASAYSVPALQTSMWQLV----------------- 538
                |.||:                  .|||...|......|...||:
pombe   499 ----IFFYI------------------QSSPPFYYGYALFPTIFLQLIHSIFPNTKLGFKNFLTV 541

  Fly   539 ----------------LLIAC-AELMVFTFFERRLIALCFCVFACYNSW---ENFQWKSRDF-FS 582
                            |.|.| .:.:|:::|.|...::.....|.: .|   .::.:..:.. .|
pombe   542 AKQKHGFSLLKILFISLCILCLLQFIVYSYFHREGFSVILMGLAAW-PWLLHADYAFSHKTISVS 605

  Fly   583 WLALVLILSCFPLLPLSVGYQNGYLLGAGVIVIFTNSFWNSKSRLCYRNHTKY------SNALIL 641
            |..|..:|..|.:||::......::...|..:.....|:     :.||.:..:      :|..::
pombe   606 WSVLTSLLCFFTILPVNKKESLLFIFAGGFAMSVAGVFY-----ILYRRNQAFQYSSTVTNKQLV 665

  Fly   642 LQTILCAYLHSNGINIPIPLKLASWL---------YLVYAFASILLS-----------KESRLDL 686
            ||.::..      ..:|:.||:|..|         ..:.||...:.|           |...||
pombe   666 LQVLIIM------ATVPVTLKIADSLQRNIAIPPILRLVAFGLFITSYIIPSHHIRSCKHYFLD- 723

  Fly   687 RLAQIGFNLGSLYATLCTSYEAVFVQLLTIELNISL------------------RAQSARAERSV 733
            |||.:..........|..|:||:|..:|.|.|.:.:                  |.:.|:...|:
pombe   724 RLAILFLTFSPTMCMLSISFEALFYVVLFITLGLWMELETELQKYTEQLHPEYSRKKDAKFHLSL 788

  Fly   734 LRLAFTLLLYTFFSL--FGSGNIASISSFDPNIARCYLSHFAPFVIMGLVLLKLLVPVVLIMSVI 796
            ..:..:|..|.|.::  ||:||:||:|:|..:..:.::..|.|.....|::..:|||.:.:.:..
pombe   789 SHIRISLFFYIFINVAFFGTGNVASLSTFALDSVKRFIPVFNPVTQGALLMYTILVPFIALSAAF 853

  Fly   797 YANSEFVRQHEEQIFICLLLICDVMGLNFLFLVRNQGSWLDIGTSISHFVIMEVTTLVMLVIFYT 861
            ...::.:...::..|...:.:.|::.:||.:||:::|||.|||.|||||.|..     .|::|.|
pombe   854 GIMNKRLGGIQQVTFFLAVGMADIVTINFFYLVKDEGSWKDIGVSISHFCISN-----FLILFIT 913

  Fly   862 AKQLLRVIPWEEIDF 876
            |.:....|..:.|.:
pombe   914 ALEHASAILCKNITY 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	113/272 (42%)
		GPI_EPT_1	42..335	CDD:293744	125/319 (39%)
		PigN	421..834	CDD:282796	100/501 (20%)
its8	NP_595248.1	Npp1	11..618	CDD:224441	206/660 (31%)
		GPI_EPT_1	40..350	CDD:293744	125/319 (39%)
		PigN	436..891	CDD:282796	100/501 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	69	1.000	Domainoid score	I2673
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6330
Inparanoid	1	1.050	327	1.000	Inparanoid score	I529
OMA	1	1.010	-	-		QHG55072
OrthoFinder	1	1.000	-	-		FOG0004928
OrthoInspector	1	1.000	-	-		otm47052
orthoMCL	1	0.900	-	-		OOG6_103930
Panther	1	1.100	-	-	LDO	PTHR12250
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R687
SonicParanoid	1	1.000	-	-		X2480
TreeFam	1	0.960	-	-
	14	13.860