DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and PIGN

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_011524191.1	Gene:	PIGN / 23556	HGNCID:	8967	Length:	970	Species:	Homo sapiens

Alignment Length:	988	Identity:	307/988 - (31%)
Similarity:	486/988 - (49%)	Gaps:	158/988 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIAYALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRADSFFE-- 63
            ::....|::|.:...|||.|||.||::.|:|||    :..|.|||.||||.|.||.|||:.:|
Human     3 LFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQ----FTPLPPPARRLVLFVADGLRADALYELD 63

  Fly    64 --ENCRYVPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVF 126
              .|.| .|.:|.|.:.||..|:|.||||||:||||:.||||.|||.|||.:|||.||::||::|
Human    64 ENGNSR-APFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLF 127

  Fly   127 NRSSQTYAWGANDVLNVFSHVSNGGEINLRFYNHDL---DFSPGYDAYEEDEWVFKRVKLLLQQK 188
            |.|..|::||:.|:|.:|:..::|..:..  |::|.   ||. ..||.:.|.|||..||......
Human   128 NESKYTWSWGSPDILPMFAKGASGDHVYT--YSYDAKREDFG-AQDATKLDTWVFDNVKDFFHHA 189

  Fly   189 RE-----ALQRAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVF-PDKR 247
            |.     :....:.:||||||||:||.||.|:|.:..::..::|.:.||..|...|...: .|.:
Human   190 RNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGK 254

  Fly   248 TAYLLTADHGMTDSGAHGSGSPHETDTPFMLWGAG---ASRAVPKPGGRTFMPNNEGPAMPLHEL 309
            |.::.|:||||||.|:||:|.|.||.||.:.||||   ..|...:.....|:...........::
Human   255 TTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDV 319

  Fly   310 EQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEYEAMAAHVNALQLLEQYVALQKQHKKGFFA 374
            .||.:.|||::|:|:..|:|:.|.||:.|||.:..::|.:...||:|:|||:.....|.|:....
Human   320 NQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLP 384

  Fly   375 DILLEYDVLNAEAIKRYKDTIVQLQKKREY----------SLCIDKSQVIMSQALEGIDYYHGYY 429
            .:...:.:|:..  |::.    .|:|.|.|          |||    :.::..||:|:.|||.|.
Human   385 FLFTPFKLLSDS--KQFN----ILRKARSYIKHRKFDEVVSLC----KELIHLALKGLSYYHTYD 439

  Fly   430 RRVLLLSTTSTFLGWMFYIYRLLSRNRASKVELV---LERSNKIVRVSIVSSVIVLIICLLSQGT 491
            |..|.::....|:||:.|...|:.::.::.::.|   :::.:.::..|.|:..|::...||.|..
Human   440 RFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQAC 504

  Fly   492 PLDISFYLLLPYFVWLKALQPWNINFSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRL 556
            |.....|.|||..:|...|:.:.: ......|..:.| |...:..|:......|::|.:||.|.:
Human   505 PWTYYVYGLLPLPIWYAVLREFQV-IQDLVVSVLTYP-LSHFVGYLLAFTLGIEVLVLSFFYRYM 567

  Fly   557 IALCFCVFACY----NSWENFQWKSRDFFSWLALVLILSCFPLLPLSVGYQN--GYLLGAGVIVI 615
            :......||.:    ..|...:..|   .||....|:|:.|||:|: ||.:.  ..::|||::|:
Human   568 LTAGLTAFAAWPFLTRLWTRAKMTS---LSWTFFSLLLAVFPLMPV-VGRKPDISLVMGAGLLVL 628

  Fly   616 FTNSFWNSKSRLCY------RNHTKYSNALI-----LLQTILCAY---------LHSNGINIPIP 660
            ..:        ||.      |..:.....|:     :|.|:|..|         |...|  :|:.
Human   629 LLS--------LCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQG--LPLM 683

  Fly   661 LKLASWLYLVYAFASILLSKESRLDLRLAQIGFNLGSLYATLCTSYEAVFVQLLTIELNISLRAQ 725
            .::.||..|..:....|||... |..||..|..:|.|.|..|.|.|||:|..:|:..:.:.:..:
Human   684 NQIISWATLASSLVVPLLSSPV-LFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIE 747

  Fly   726 SARAERS----------------------------VLRLAFTLLLYTFFSLFGSGNIASISSFDP 762
            ....::|                            .:|.||.|:.:...:.||:||||||:|||.
Human   748 QETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDL 812

  Fly   763 NIARCYLSHFAPFVIMGLVLLKLLVPVVLIMSVIYANSEFVRQHEEQIFICLLLICDVMGLNFLF 827
            ....|:|:.|:||::..|::.|:|:|.||:|....|.....:...:.:|:.:|:|.|:|.|:|.|
Human   813 ASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFF 877

  Fly   828 LVRNQGSWLDIGT---------------------------------------SISHFVIMEVTTL 853
            ||::.||||||||                                       .|||:||: ::..
Human   878 LVKDYGSWLDIGTRQLLACTAWLFMYISASPNRLWMLSDPGLDLNLLHAIRACISHYVIV-MSMT 941

  Fly   854 VMLVIFYTAKQLL 866
            :.||......|||
Human   942 IFLVFLNGLAQLL 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	116/267 (43%)
		GPI_EPT_1	42..335	CDD:293744	126/308 (41%)
		PigN	421..834	CDD:282796	123/469 (26%)
PIGN	XP_011524191.1	Npp1	7..>280	CDD:224441	122/280 (44%)
		GPI_EPT_1	40..345	CDD:293744	126/308 (41%)
		PigN	431..884	CDD:282796	123/469 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159767
Domainoid	1	1.000	142	1.000	Domainoid score	I4701
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6330
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1629
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	1	1.000	-	-		FOG0004928
OrthoInspector	1	1.000	-	-		otm40554
orthoMCL	1	0.900	-	-		OOG6_103930
Panther	1	1.100	-	-	LDO	PTHR12250
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R687
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.890