DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-N and Enpp4

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_006524196.1	Gene:	Enpp4 / 224794	MGIID:	2682634	Length:	470	Species:	Mus musculus

Alignment Length:	460	Identity:	101/460 - (21%)
Similarity:	155/460 - (33%)	Gaps:	175/460 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LYYGL---------EPPANRLVLIVTDGFRADSFFEENCRYVPNLRKIFLREGVVGVSRTR--VP 90
            |::||         :..|.||:|:..||||||.....:..::.|    |::|||: |...:  ..
Mouse    25 LFWGLVTGYKGNSSDSSAPRLLLVSFDGFRADYLKSYDLPHLQN----FIKEGVL-VEHVKNVFI 84

  Fly    91 TETRPGHITLIAGLYEDPSAVLRG----------------------------WKSNPIDFDTVFN 127
            |:|.|.|.:::.||||:...::..                            |.:|.:.    .|
Mouse    85 TKTFPNHYSIVTGLYEESHGIVANSMYDSVTKKHFSESNDKDPFWWNGAEPIWVTNQLQ----EN 145

  Fly   128 RSSQTYAWGANDV----------LNVFSHV---------------SNGGEINLRFYNHDLDFSPG 167
            |||....|...||          :|..|.|               ||........|..:.|.| |
Mouse   146 RSSAAAMWPGTDVPIHNITASYFMNYSSSVSFKERLGNVTTWLSSSNPPVTFAALYWEEPDVS-G 209

  Fly   168 YDAYEEDEWVFKRV---------KLLLQQKREALQRAQNVVFFL----------HLLGLDTAGHV 213
            :....||:...:||         .::|:.|...|..:.||:...          .|:.||:.  :
Mouse   210 HKYGPEDKENMRRVLKEVDDLIGDIVLKLKVLGLWDSLNVIITSDHGMAQCSKNRLIDLDSC--I 272

  Fly   214 HK---------PGA---PKFRRT--LEKTEK-----GVY---AI-----YQEFERVFPDKRTAYL 251
            .:         |.|   ||...|  .:|.::     .||   ||     ||...|:.|     .:
Mouse   273 DRSNYSVIDLTPVAAILPKINVTEVYDKLKRCNPHMNVYLKEAIPNRFYYQHSSRIQP-----II 332

  Fly   252 LTADHGMTDS--------GAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNEGPAM---- 304
            |.|:.|.|.:        |.||..:...:..||:.                    ..|||.
Mouse   333 LVAEEGWTITLNKSSFKLGDHGYDNSLPSMHPFLA--------------------AHGPAFRKGY 377

  Fly   305 PLHELEQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSKEY----------EAMAAHVNALQLLE 359
            ....:....:.|:|..:|||.|..||      |.|:.:|..          ||:...|:||.:|.
Mouse   378 RQSTINTVDIYPMMCHILGLKPHPNN------GTLSHTKCLLVDQWCINLPEAIGIVVSALLVLT 436

  Fly   360 QYVAL 364
            ....|
Mouse   437 MLTGL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	76/345 (22%)
		GPI_EPT_1	42..335	CDD:293744	88/405 (22%)
		PigN	421..834	CDD:282796
Enpp4	XP_006524196.1	Enpp	43..396	CDD:293742	81/389 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810