DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and Enpp1

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001295256.1	Gene:	Enpp1 / 18605	MGIID:	97370	Length:	906	Species:	Mus musculus

Alignment Length:	761	Identity:	150/761 - (19%)
Similarity:	240/761 - (31%)	Gaps:	324/761 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPANRLVLIVTDGFRADSFFE-----------ENC-RYVPNLRKIFLREGVVGVSRTRVPTETRP 95
            ||.   :|...|||||:....           :|| .|..|:|.::             ||:|.|
Mouse   192 PPT---LLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPMY-------------PTKTFP 240

  Fly    96 GHITLIAGLYEDPSAVLRG-----------------------WKSNPIDFDTVFNR--SSQTYAW 135
            .|.:::.|||.:...::..                       :|..|| :.|..::  .|.||.|
Mouse   241 NHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPI-WVTANHQEVKSGTYFW 304

  Fly   136 GANDVLNVFSHVSNGGEIN------LRFYNHDLDFSPGYDAYEEDEWVFKRVKLLLQQKREALQR 194
            ..:||           ||:      .:.||..:.|.             :|:..:|    |.||.
Mouse   305 PGSDV-----------EIDGILPDIYKVYNGSVPFE-------------ERILAVL----EWLQL 341

  Fly   195 AQNV---VFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADH 256
            ..:.   .:.|:|...|::||.|.|.:.:..:.|:|.::.|..:....:.:..||....:|.:||
Mouse   342 PSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDH 406

  Fly   257 GMTDSGAHGSGSPH--------ETDTPFMLWGAGASRAVPKPGGRTFM---------------PN 298
            ||    ..||...:        :.:...:::|. |:|..|.....|:.               ||
Mouse   407 GM----EQGSCKKYVYLNKYLGDVNNVKVVYGP-AARLRPTDVPETYYSFNYEALAKNLSCREPN 466

  Fly   299 NE-----GPAMP--LHELEQAQLTPLMSAL-----LGLAPP---------------MNNFGKLPL 336
            ..     .|.:|  ||..:..::.||...|     |.|.|.               .:|...|.:
Mouse   467 QHFRPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFI 531

  Fly   337 GYLNVSKEYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAEAIKRYKDTIVQLQKK 401
            ||....|.    .|.|::.:.:|.|         ....|:|......|..:    ..::..|.||
Mouse   532 GYGPAFKH----GAEVDSFENIEVY---------NLMCDLLGLIPAPNNGS----HGSLNHLLKK 579

  Fly   402 REYSLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFLG-----WMFYIYRLLSRNRASKVE 461
            ..|:....|.:..:||.               .:.:||..||     |:..|     ::...::.
Mouse   580 PIYNPSHPKEEGFLSQC---------------PIKSTSNDLGCTCDPWIVPI-----KDFEKQLN 624

  Fly   462 LVLERSNKIVRVSI-VSSVIVLI----ICLLSQ-----GTPLDISFYLLLPYFVWLKALQPWNIN 516
            |..|..:.|..::: .....:|:    :|||.|     |..||    ||:|
Mouse   625 LTTEDVDDIYHMTVPYGRPRILLKQHRVCLLQQQQFLTGYSLD----LLMP-------------- 671

  Fly   517 FSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIALCFCVFACYNSWENFQWKSRDFF 581
                             :|                             |.|....|.|: |||.|
Mouse   672 -----------------LW-----------------------------ASYTFLSNDQF-SRDDF 689

  Fly   582 SWLALVLILSC------FPLLPLSVGYQNGYLLGAGVIVIFTNSFWNSKSRLCY----------- 629
            |        :|      .||.|                 :...|::.|.|:|.|
Mouse   690 S--------NCLYQDLRIPLSP-----------------VHKCSYYKSNSKLSYGFLTPPRLNRV 729

  Fly   630 RNHTKYSNALI-----------------LLQTILCAYLHS-NGINI 657
            .||. ||.||:                 |..|:|..|.|. ||||:
Mouse   730 SNHI-YSEALLTSNIVPMYQSFQVIWHYLHDTLLQRYAHERNGINV 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	58/267 (22%)
		GPI_EPT_1	42..335	CDD:293744	78/387 (20%)
		PigN	421..834	CDD:282796	54/287 (19%)
Enpp1	NP_001295256.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Di-leucine motif. /evidence=ECO:0000269\|PubMed:11598187, ECO:0000269\|PubMed:15075217	27..34
		SO	86..126	CDD:197571
		SO	127..170	CDD:197571
		Phosphodiesterase. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	173..573		89/447 (20%)
		Enpp	192..560	CDD:293742	87/430 (20%)
		Phosphodiest	194..520	CDD:279931	75/375 (20%)
		Linker. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	579..628		12/68 (18%)
		Nuclease. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	635..906		45/231 (19%)
		NUC	657..888	CDD:214683	41/209 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810