Protein Alignment PIG-N and pign-1

DIOPT Version :10

• Sequence 1: NP_610549.1
• Gene: PIG-N / 36049
• FlyBaseID: FBgn0033479
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_001249296.1
• Gene: pign-1 / 171881
• WormBaseID: WBGene00021840
• Length: 912
• Species: Caenorhabditis elegans
• Alignment Length: 962
• Identity: 289/962 - (30%)
• Similarity: 470/962 - (48%)
• Gaps: 147/962 - (15%)

  Fly     6 ALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRADSF--FEENCRY 68
            ::.||::|:.|||.:|:.||::.|:.||   .....|.||.|:.:|..||.|.|:|  :.:...|
 Worm     9 SITVHLVLIYSIFDVYYTSPLVHGIPPQ---FINSQEAPAKRIFIISADGLRYDTFNKYPDKSPY 70

  Fly    69 VPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVFNRSSQTY 133
            :.::..  .|:|:.|:||:.:|||:||||:.:.||:.||.|||.:|||.||:.||:||||||.::
 Worm    71 LHSIMN--ERKGIYGLSRSHIPTESRPGHVAIFAGITEDISAVAKGWKKNPVQFDSVFNRSSYSW 133

  Fly   134 AWGANDVLNVFSHVSNGGEINLRFYNHDLDFSPGYDAYEEDEWVFKRVKLLLQQKR--EAL---Q 193
            .||:.|::|:|..:.|....:   |:.|.:.....||...|:|||:..:..|:..:  |||   .
 Worm   134 MWGSPDIVNLFDDLPNAESFS---YSADEEDFASKDASNLDKWVFEHFENFLETAKTDEALNDKM 195

  Fly   194 RAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGM 258
            |.|..:|||||||:||.||.:||.:.::...::..:.|:..:....:..|.|.:||:|.|:||||
 Worm   196 REQKSIFFLHLLGIDTNGHGNKPMSRQYIDNIKVVDSGIEKVQHLVDAFFGDHKTAWLFTSDHGM 260

  Fly   259 TDSGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNEGPAMPLHELEQAQLTPLMSALLG 323
            ||.|:||:||..|..|||:.||||.     |.||            |..:|.|..|.||:|||:|
 Worm   261 TDWGSHGAGSDDEVLTPFVAWGAGV-----KQGG------------PKLDLNQIDLAPLISALIG 308

  Fly   324 LAPPMNNFGKLPLGYLNVSK--EYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAE 386
            ...|:|:.|.||:..:| ||  .||..|...|..||.||.:.|:....:..:   ..:::....:
 Worm   309 CPIPVNSMGILPVQMMN-SKGSSYEFKAIEANFKQLKEQIIFLKNAKSRRLW---FRQFEKFGDK 369

  Fly   387 AIKRYKDTIVQLQKKREY----SLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFLGWMFY 447
            |::..:.|:.||.:.|.:    ||..|.:.::.    |.|.:||.|.|::|..:.:.:|:.|:..
 Worm   370 AMESLRTTLAQLGRDRRFSVATSLFADNAHLMK----EAIVFYHRYDRQMLGAAVSCSFVAWIAL 430

  Fly   448 IYRLLSRNRASKVELVLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFV------- 505
            :...| .|..||..|.|...:.:..:.:..|::....|.||    :..:.|::||.::
 Worm   431 VVSFL-HNSTSKENLSLLVPHHLFIIPLACSLLFTAYCSLS----MTQTIYIILPIYLISILENH 490

  Fly   506 ---------WLKAL--QPWNINFSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIAL 559
                     .:|||  ||..:|...| ...:..|.|....:.:.:.|     .|.||.:|..:|.
 Worm   491 SKLTQRIREHVKALSAQPDWLNKVLS-VEVFVKPFLGFVGFSITICI-----FVLTFMDRAFLAA 549

  Fly   560 CFCVFACYNSWENFQWKSRDFFSWLALVLILSCFPLLPLSVGYQNGYLLG--AGVIVIFTNSFWN 622
            .|.:......:.:....|....:||.|.|:|..||.|| :||......|.  :.:|..|
 Worm   550 VFVLLMALPQFYSHPIVSYWSKTWLTLCLVLCIFPFLP-AVGVSTHIPLCILSPIITAF------ 607

  Fly   623 SKSRLCYRNHTKYSNALILLQTILCAYLHSNGINIPIPLKLASWLYLVYAFASILLSKESRLDLR 687
                ||:|...:  :.|..:|.:|...::   :.......:|...|....||:.:......|||.
 Worm   608 ----LCHRLSRR--SCLTRIQRMLELMIY---VQSATAFMIAVVNYGFEKFAATVNCSMDLLDLN 663

  Fly   688 --------LAQIGFNLGSL--------------YATLCTSYEA----VFVQLLT----------- 715
                    :|....:.||.              |:.|..|||:    :|:.|||
 Worm   664 PTFCDCSVVAHGSISCGSSNCIRLMLLCEKIVPYSLLSISYESLFMLIFLVLLTLFVRFEFGHLS 728

  Fly   716 -IELNISLRAQSAR---AERSVLRLAFTLLLYTFFSLFGSGNIASISSFDPNIARCYLSHFAPFV 776
             :|| :.|:..|.:   .|...||.....:.:....|||:||.|||:||:|:....::|.|:||.
 Worm   729 DVEL-LQLKVDSTKISTGEYVELRRTVVCVSFVLCPLFGTGNFASINSFNPSTLNLFISVFSPFT 792

  Fly   777 IMGLVLLKLLVPVVLIMSVIYANSEFVRQHEEQI--FICL-LLICDVMGLNFLFLVRNQGSWLDI 838
            :..|::||||:|::|:.|   |.:..||..:|.|  ..|. |:..|.|.:.|...:|::||||||
 Worm   793 MAILLILKLLIPILLVTS---AFASIVRFDQESIQRLCCFSLIFTDFMSMCFFHQLRDEGSWLDI 854

  Fly   839 GTSISHFVIMEVTTLVMLVIFYTAKQLLRVIPWEEIDFKMLPLRLIHWDVIS 890
            |.|||.|::....:|.:|::...:..|:      ..:|:..|.:..|.::.|
 Worm   855 GMSISQFIVSMCISLALLLLLSISSHLM------AFEFRKFPGKRNHQEIES 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	GPI_EPT_1	42..335	CDD:293744	118/299 (39%)
		PigN	420..834	CDD:461508	119/477 (25%)
pign-1	NP_001249296.1	GPI_EPT_1	42..320	CDD:293744	118/299 (39%)
		Csm2_III-A	<337..411	CDD:469848	18/80 (23%)
		PigN	403..850	CDD:461508	119/477 (25%)