DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-N and pign-1

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001249296.1	Gene:	pign-1 / 171881	WormBaseID:	WBGene00021840	Length:	912	Species:	Caenorhabditis elegans

Alignment Length:	962	Identity:	289/962 - (30%)
Similarity:	470/962 - (48%)	Gaps:	147/962 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALVVHVLLLGSIFVIYFRSPVITGLTPQKHLLYYGLEPPANRLVLIVTDGFRADSF--FEENCRY 68
            ::.||::|:.|||.:|:.||::.|:.||   .....|.||.|:.:|..||.|.|:|  :.:...|
Worm     9 SITVHLVLIYSIFDVYYTSPLVHGIPPQ---FINSQEAPAKRIFIISADGLRYDTFNKYPDKSPY 70

  Fly    69 VPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLYEDPSAVLRGWKSNPIDFDTVFNRSSQTY 133
            :.::..  .|:|:.|:||:.:|||:||||:.:.||:.||.|||.:|||.||:.||:||||||.::
Worm    71 LHSIMN--ERKGIYGLSRSHIPTESRPGHVAIFAGITEDISAVAKGWKKNPVQFDSVFNRSSYSW 133

  Fly   134 AWGANDVLNVFSHVSNGGEINLRFYNHDLDFSPGYDAYEEDEWVFKRVKLLLQQKR--EAL---Q 193
            .||:.|::|:|..:.|....:   |:.|.:.....||...|:|||:..:..|:..:  |||   .
Worm   134 MWGSPDIVNLFDDLPNAESFS---YSADEEDFASKDASNLDKWVFEHFENFLETAKTDEALNDKM 195

  Fly   194 RAQNVVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEKGVYAIYQEFERVFPDKRTAYLLTADHGM 258
            |.|..:|||||||:||.||.:||.:.::...::..:.|:..:....:..|.|.:||:|.|:||||
Worm   196 REQKSIFFLHLLGIDTNGHGNKPMSRQYIDNIKVVDSGIEKVQHLVDAFFGDHKTAWLFTSDHGM 260

  Fly   259 TDSGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTFMPNNEGPAMPLHELEQAQLTPLMSALLG 323
            ||.|:||:||..|..|||:.||||.     |.||            |..:|.|..|.||:|||:|
Worm   261 TDWGSHGAGSDDEVLTPFVAWGAGV-----KQGG------------PKLDLNQIDLAPLISALIG 308

  Fly   324 LAPPMNNFGKLPLGYLNVSK--EYEAMAAHVNALQLLEQYVALQKQHKKGFFADILLEYDVLNAE 386
            ...|:|:.|.||:..:| ||  .||..|...|..||.||.:.|:....:..:   ..:::....:
Worm   309 CPIPVNSMGILPVQMMN-SKGSSYEFKAIEANFKQLKEQIIFLKNAKSRRLW---FRQFEKFGDK 369

  Fly   387 AIKRYKDTIVQLQKKREY----SLCIDKSQVIMSQALEGIDYYHGYYRRVLLLSTTSTFLGWMFY 447
            |::..:.|:.||.:.|.:    ||..|.:.::.    |.|.:||.|.|::|..:.:.:|:.|:..
Worm   370 AMESLRTTLAQLGRDRRFSVATSLFADNAHLMK----EAIVFYHRYDRQMLGAAVSCSFVAWIAL 430

  Fly   448 IYRLLSRNRASKVELVLERSNKIVRVSIVSSVIVLIICLLSQGTPLDISFYLLLPYFV------- 505
            :...| .|..||..|.|...:.:..:.:..|::....|.||    :..:.|::||.::
Worm   431 VVSFL-HNSTSKENLSLLVPHHLFIIPLACSLLFTAYCSLS----MTQTIYIILPIYLISILENH 490

  Fly   506 ---------WLKAL--QPWNINFSSSPASAYSVPALQTSMWQLVLLIACAELMVFTFFERRLIAL 559
                     .:|||  ||..:|...| ...:..|.|....:.:.:.|     .|.||.:|..:|.
Worm   491 SKLTQRIREHVKALSAQPDWLNKVLS-VEVFVKPFLGFVGFSITICI-----FVLTFMDRAFLAA 549

  Fly   560 CFCVFACYNSWENFQWKSRDFFSWLALVLILSCFPLLPLSVGYQNGYLLG--AGVIVIFTNSFWN 622
            .|.:......:.:....|....:||.|.|:|..||.|| :||......|.  :.:|..|
Worm   550 VFVLLMALPQFYSHPIVSYWSKTWLTLCLVLCIFPFLP-AVGVSTHIPLCILSPIITAF------ 607

  Fly   623 SKSRLCYRNHTKYSNALILLQTILCAYLHSNGINIPIPLKLASWLYLVYAFASILLSKESRLDLR 687
                ||:|...:  :.|..:|.:|...::   :.......:|...|....||:.:......|||.
Worm   608 ----LCHRLSRR--SCLTRIQRMLELMIY---VQSATAFMIAVVNYGFEKFAATVNCSMDLLDLN 663

  Fly   688 --------LAQIGFNLGSL--------------YATLCTSYEA----VFVQLLT----------- 715
                    :|....:.||.              |:.|..|||:    :|:.|||
Worm   664 PTFCDCSVVAHGSISCGSSNCIRLMLLCEKIVPYSLLSISYESLFMLIFLVLLTLFVRFEFGHLS 728

  Fly   716 -IELNISLRAQSAR---AERSVLRLAFTLLLYTFFSLFGSGNIASISSFDPNIARCYLSHFAPFV 776
             :|| :.|:..|.:   .|...||.....:.:....|||:||.|||:||:|:....::|.|:||.
Worm   729 DVEL-LQLKVDSTKISTGEYVELRRTVVCVSFVLCPLFGTGNFASINSFNPSTLNLFISVFSPFT 792

  Fly   777 IMGLVLLKLLVPVVLIMSVIYANSEFVRQHEEQI--FICL-LLICDVMGLNFLFLVRNQGSWLDI 838
            :..|::||||:|::|:.|   |.:..||..:|.|  ..|. |:..|.|.:.|...:|::||||||
Worm   793 MAILLILKLLIPILLVTS---AFASIVRFDQESIQRLCCFSLIFTDFMSMCFFHQLRDEGSWLDI 854

  Fly   839 GTSISHFVIMEVTTLVMLVIFYTAKQLLRVIPWEEIDFKMLPLRLIHWDVIS 890
            |.|||.|::....:|.:|::...:..|:      ..:|:..|.:..|.::.|
Worm   855 GMSISQFIVSMCISLALLLLLSISSHLM------AFEFRKFPGKRNHQEIES 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	101/261 (39%)
		GPI_EPT_1	42..335	CDD:293744	118/299 (39%)
		PigN	421..834	CDD:282796	118/476 (25%)
pign-1	NP_001249296.1	GPI_EPT_1	42..320	CDD:293744	118/299 (39%)
pign-1	NP_001249296.1	PigN	404..850	CDD:368221	118/476 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167301
Domainoid	1	1.000	94	1.000	Domainoid score	I4699
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6330
Inparanoid	1	1.050	368	1.000	Inparanoid score	I1241
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	1	1.000	-	-		FOG0004928
OrthoInspector	1	1.000	-	-		otm14712
orthoMCL	1	0.900	-	-		OOG6_103930
Panther	1	1.100	-	-	LDO	PTHR12250
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R687
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940