DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-N and enpp2

DIOPT Version :9

Sequence 1:	NP_610549.1	Gene:	PIG-N / 36049	FlyBaseID:	FBgn0033479	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_009290357.1	Gene:	enpp2 / 100332039	ZFINID:	ZDB-GENE-040426-1156	Length:	854	Species:	Danio rerio

Alignment Length:	415	Identity:	84/415 - (20%)
Similarity:	154/415 - (37%)	Gaps:	97/415 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LEPPANRLVLIVTDGFRADSFFEENCRYVPNLRKIFLREGVVGVSRTRVPTETRPGHITLIAGLY 105
            :.||   ::::..||||| |:.:.....:||:.|:..........|...||:|.|...|:..|||
Zfish   157 VRPP---VIMLSVDGFRA-SYMKRGGTVIPNIEKLRSCGTHAPYMRPMYPTKTYPNLYTITTGLY 217

  Fly   106 EDPSAVLRGWKSNPIDFDTVFN-RSSQTYA---WGANDVLNVFSHVSNGGEINLRFYNHDLDFSP 166
            .:...::.....:| .||..|| |..:...   ||...:.  .:.:..|.:....|:...:...
Zfish   218 PESHGIVGNSIHDP-SFDANFNFRGKEKLNHRWWGGQPIW--ITAMKQGVKAGSFFWPVAIPME- 278

  Fly   167 GYDAYEEDEWVFKRVKLLLQQKREALQRAQN-VVFFLHLLGLDTAGHVHKPGAPKFRRTLEKTEK 230
                        :||..:||...  |..|:. .::.:|...||:.||...|.:.:....|...:|
Zfish   279 ------------RRVLTMLQWLH--LPDAERPYLYAMHSEQLDSYGHKLGPHSTELNSALRDVDK 329

  Fly   231 GVYAIYQEFERVFPDKRTAYLLTADHGMTDSGAHGSGSPHETDTPFMLWGAGASRAVPKPGGRTF 295
            .:..:....:::...:....:|..||||.::        |...|.|:               .::
Zfish   330 VIGQLMNGLKQMKLHRCINIILVGDHGMEEA--------HCDKTEFL---------------SSY 371

  Fly   296 MPNNEGPAMPLHELEQAQLTPLMSALLGLAPPMNNFGKLPLGYLNVSK-EYEAMAAHVNALQLLE 359
            |.|.|.                    |.|.|  .:.|::.....|.|| :.:|:.|::...:..:
Zfish   372 MSNTED--------------------LILIP--GSLGRIRARNPNNSKFDAKAVVANLTCKKPDQ 414

  Fly   360 QYVALQKQH--KKGFFA--DILLEYDVLNAEAIKRYKDTIVQLQK-KREYSLCIDKSQVIMSQAL 419
            .:....|||  |:..:|  |.:.|..::    ::|......::.| ||.:..|
Zfish   415 HFKPYLKQHLPKRLHYANNDRIEEIHLM----VERKWHIARKIMKTKRNHEKC------------ 463

  Fly   420 EGIDYYHGYYRRVLLLSTTSTFLGW 444
             |....|||..::..:.|  .|||:
Zfish   464 -GFAGDHGYDNKINSMQT--IFLGY 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-N	NP_610549.1	Npp1	10..>265	CDD:224441	49/228 (21%)
		GPI_EPT_1	42..335	CDD:293744	59/297 (20%)
		PigN	421..834	CDD:282796	8/24 (33%)
enpp2	XP_009290357.1	Somatomedin_B	52..91	CDD:279385
		SO	98..137	CDD:197571
		Enpp	159..512	CDD:293742	84/413 (20%)
		Phosphodiest	161..472	CDD:279931	77/391 (20%)
		NUC	589..846	CDD:238043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810