DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment magu and SPOCK2

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001231879.1	Gene:	SPOCK2 / 9806	HGNCID:	13564	Length:	424	Species:	Homo sapiens

Alignment Length:	443	Identity:	82/443 - (18%)
Similarity:	119/443 - (26%)	Gaps:	229/443 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VCGTDGQTYPTRCHLLRAQCGGHQVSLKYSGSCNACLEAVKFARRQQERDPGYFVPRCRKDGNFA 109
            |||:||.||.:.|.|.:                .|||.:.:.
Human   147 VCGSDGHTYSSVCKLEQ----------------QACLSSKQL----------------------- 172

  Fly   110 AMQCYGNNGCWCSDSQGRPIADDNKQFRRKGKLRCRANRRDRRRLASHQIGYNPDTSASKGSSEA 174
            |::|.|  .|.|...|..                                     ||.:.|..|
Human   173 AVRCEG--PCPCPTEQAA-------------------------------------TSTADGKPE- 197

  Fly   175 GSTAHRTCSKSDRSQFNTNLMRMF--------RNEAQSFFRQP----------SLSDSHILEWQF 221
                  ||:..|.:.....|...|        :|.:.|....|          |..||  :.|.|
Human   198 ------TCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPASGLDKSLGASCKDS--IGWMF 254

  Fly   222 SKLDTNGNKLLDRQEIRELKKVLRRNV-KPRRCGRTFGKYCDVTKDANLNWLEWSVCFTKEFHNR 285
            |||||:.:..||:.|:..:      |: |...|.|.|...||..||..::..||..||.:|
Human   255 SKLDTSADLFLDQTELAAI------NLDKYEVCIRPFFNSCDTYKDGRVSTAEWCFCFWRE---- 309

  Fly   286 SAVVNLLASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASGSEEHEDNYEDS 350
                         .||
Human   310 -------------KPP------------------------------------------------- 312

  Fly   351 ATGYGGEEDDSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMD-QSVTLEEQGHGGKSV 414
                                                         |..: :.:.::|... .|..
Human   313 ---------------------------------------------CLAELERIQIQEAAK-KKPG 331

  Fly   415 LFVPQCLPDGRYQRIQCYSSTSTSYCWCVNEDTGKSIPGTSVKNKRPQCDESV 467
            :|:|.|..||.|:::||  ..|:..||||:: .|..:.||..... |.||:.|
Human   332 IFIPSCDEDGYYRKMQC--DQSSGDCWCVDQ-LGLELTGTRTHGS-PDCDDIV 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	9/31 (29%)
		TY	88..139	CDD:238114	6/50 (12%)
		SPARC_Ca_bdg	180..274	CDD:287550	30/112 (27%)
		SPARC_EC	<219..281	CDD:238155	23/62 (37%)
		TY	396..463	CDD:238114	20/67 (30%)
SPOCK2	NP_001231879.1	KAZAL	<147..180	CDD:197624	15/73 (21%)
		SPARC_Ca_bdg	197..303	CDD:287550	32/120 (27%)
		SPARC_EC	198..316	CDD:238155	38/236 (16%)
		TY	312..376	CDD:238114	21/162 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910