DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment magu and igfbp2a

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_571533.1	Gene:	igfbp2a / 794176	ZFINID:	ZDB-GENE-000125-12	Length:	276	Species:	Danio rerio

Alignment Length:	486	Identity:	83/486 - (17%)
Similarity:	126/486 - (25%)	Gaps:	230/486 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CVLFVTWLAVFIATGKSDDQLMKLPACAAKQGECDDNEGPVCGTDGQTYPTRCHLLRAQCGGHQV 69
            |.|.:. |..|..|.:| :.:.:.|:|.|::                  ...|.:|...| |..|
Zfish     7 CGLLLA-LVTFHGTARS-EMVFRCPSCTAER------------------QAACPMLTETC-GEIV 50

  Fly    70 SLKYSGSCNACLEAVKFARRQQERDPGYFVPRCRKDGNFAAMQCYGNNGCWCSDSQGRPIADDNK 134
            .....|.|..|       .||:....|.:.|||.     :.::||           .:|.::...
Zfish    51 REPGCGCCPVC-------ARQEGEQCGVYTPRCS-----SGLRCY-----------PKPDSELPL 92

  Fly   135 QFRRKGKLRCRANRRDRRRLASHQIGYNPDTSASKGSSEAGSTAHRTCSKSDRSQFNTNLMRMFR 199
            :...:|..||               |...||..: ||:|.                     |...
Zfish    93 ELLVQGLGRC---------------GRKVDTEPT-GSAEP---------------------REVS 120

  Fly   200 NEAQSFFRQPSLSDSHILEWQFSKLDTNGNKLLDRQEIRELKKVLRRNVKPRRCGRTFGKYCDVT 264
            .|.|                  ..||..   |.:...||          ||             |
Zfish   121 GEVQ------------------DPLDIG---LTEVPPIR----------KP-------------T 141

  Fly   265 KDANLNWLEWSVCFTKEFHNRSAVVNLLASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVN 329
            ||:  .|.|            |||:.                  |...:....:.|
Zfish   142 KDS--PWKE------------SAVLQ------------------HRQQLKSKMKYH--------- 165

  Fly   330 PHSYSEDASGSEEHEDNYEDSATGYGGEEDDSQGAD----------LPSSRTHIPSLYMLNSKPE 384
                            ..||....:..:....|..|          ...:||.:..||.|:
Zfish   166 ----------------KVEDPKAPHAKQSQCQQELDQVLERISKITFKDNRTPLEDLYSLH---- 210

  Fly   385 TASQDLENDSNCWMDQSVTLEEQGHGGKSVLFVPQCLPDGRYQRIQCYSSTS--TSYCWCVNEDT 447
                                            :|.|...|:|...||..|.:  ...|||||..|
Zfish   211 --------------------------------IPNCDKRGQYNLKQCKMSVNGYRGECWCVNPHT 243

  Fly   448 GKSIPGTSVKNKRPQCDESVAVRPMKGCTEP 478
            |:.:|.:.:....|.|::.:..:.|....:|
Zfish   244 GRPMPTSPLIRGDPNCNQYLDGQEMDPSVDP 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	6/38 (16%)
		TY	88..139	CDD:238114	9/50 (18%)
		SPARC_Ca_bdg	180..274	CDD:287550	14/93 (15%)
		SPARC_EC	<219..281	CDD:238155	12/61 (20%)
		TY	396..463	CDD:238114	16/68 (24%)
igfbp2a	NP_571533.1	IB	26..102	CDD:197525	21/117 (18%)
		Thyroglobulin_1	180..259	CDD:278514	23/114 (20%)
		Cell attachment site. /evidence=ECO:0000255	254..256		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000