Protein Alignment magu and SMOC1

DIOPT Version :9

• Sequence 1: NP_610548.2
• Gene: magu / 36048
• FlyBaseID: FBgn0262169
• Length: 613
• Species: Drosophila melanogaster
• Sequence 2: XP_005268052.1
• Gene: SMOC1 / 64093
• HGNCID: 20318
• Length: 446
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 129/573 - (22%)
• Similarity: 196/573 - (34%)
• Gaps: 229/573 - (39%)

  Fly    44 PVCGTDGQTYPTRCHLLRAQCGGHQVSLKYSGSC-----NAC----LEAVKFARRQQERDPGYFV 99
            |:|.:||::|.:.|...||:|....:.:.:.|.|     :.|    .:|::.|::.||   ..||
Human    54 PICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQAKKPQE---AVFV 115

  Fly   100 PRCRKDGNFAAMQCYGNNG-CWCSDSQGRPIADDNKQFRRKGKLRCRANRRDRRRLASHQIGYNP 163
            |.|.:||:|..:||:...| |||....|:||:
Human   116 PECGEDGSFTQVQCHTYTGYCWCVTPDGKPIS--------------------------------- 147

  Fly   164 DTSASKGSSEAGSTAHRTCSKSDR--SQFNTNLMRMFRNEAQSFFRQPSLSDSHILEWQFSK--- 223
                  |||....|...:.|.:|:  ||.|:.....||     ||...:..|.       ||
Human   148 ------GSSVQNKTPVCSGSVTDKPLSQGNSGRKVSFR-----FFLTLNSDDG-------SKPTP 194

  Fly   224 -LDTNGNKLLDRQEIRE----LKKVLRRNVKPRRCGRTFGKYCDVTKDANLNWLEWSVCFTKEFH 283
             ::|  ..:.|..||..    :|.:                   |.||:.||
Human   195 TMET--QPVFDGDEITAPTLWIKHL-------------------VIKDSKLN------------- 225

  Fly   284 NRSAVVNLLASSAATAPPHSTHYSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASGSEEHEDNYE 348
                                      |||:.
Human   226 --------------------------NTNIR---------------------------------- 230

  Fly   349 DSATGYGGEEDDSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMDQSVTLEEQGHGGKS 413
                                           ||         |...:|..::...|||.....:.
Human   231 -------------------------------NS---------EKVYSCDQERQSALEEAQQNPRE 255

  Fly   414 VLFVPQCLPDGRYQRIQCYSSTSTSYCWCVNEDTGKSIPGTSVKNKRPQC-----------DESV 467
            .:.:|:|.|.|.|:.:||:.  ||.|||||..|||:.:||||.:...|.|           |:..
Human   256 GIVIPECAPGGLYKPVQCHQ--STGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKTTEADDPF 318

  Fly   468 AVRPMKGCTEPRKTQFLKELKAYLNTSLL----PSSTTG----SNSSMWKTDDERIATLSFVYLD 524
            ..|.:.||.|.:|.:|:..|...|.|.::    .::.||    |......|.:||:....|..||
Human   319 KDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLD 383

  Fly   525 KNKNKSWDRREWKNFRDLVTSASHLRRCGKKMPRYCDVNGDKKISLAEWLNCL 577
            .|.:...::||.|.|:..|...:..::|.::...|||:|.||.|||.|...||
Human   384 SNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCL 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	10/32 (31%)
		TY	88..139	CDD:238114	18/51 (35%)
		SPARC_Ca_bdg	180..274	CDD:287550	22/103 (21%)
		SPARC_EC	<219..281	CDD:238155	12/69 (17%)
		TY	396..463	CDD:238114	26/66 (39%)
SMOC1	XP_005268052.1	KAZAL_FS	47..87	CDD:238052	10/32 (31%)
		Thyroglobulin_1	95..158	CDD:278514	25/104 (24%)
		Thyroglob_assoc	159..228	CDD:293205	23/140 (16%)
		TY	237..303	CDD:238114	26/67 (39%)
		SPARC_EC	<375..436	CDD:238155	20/60 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158075
Domainoid	1	1.000	59	1.000	Domainoid score	I10670
eggNOG	1	0.900	-	-		E1_KOG4578
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3765
Isobase	1	0.950	-	0	Normalized mean entropy	S7093
OMA	1	1.010	-	-		QHG47194
OrthoDB	1	1.010	-	-		D1057719at2759
OrthoFinder	1	1.000	-	-		FOG0004129
OrthoInspector	1	1.000	-	-		otm42301
orthoMCL	1	0.900	-	-		OOG6_109000
Panther	1	1.100	-	-	LDO	PTHR12352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3895
SonicParanoid	1	1.000	-	-		X2872
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750