DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment magu and Smoc2

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_006524840.1	Gene:	Smoc2 / 64074	MGIID:	1929881	Length:	458	Species:	Mus musculus

Alignment Length:	639	Identity:	147/639 - (23%)
Similarity:	224/639 - (35%)	Gaps:	244/639 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QLMKLPACAA---------------------KQGEC-----DDNEGPVCGTDGQTYPTRCHLLRA 62
            ||..||..||                     |..:|     ...:.|:|.:||:|:.:||...||
Mouse     5 QLCWLPLLAALLPPVPAQKFSALTFLRVDQDKDRDCSLDCPSSPQKPLCASDGRTFLSRCEFQRA 69

  Fly    63 QCGGHQVSLKYSGSC---NACLEAVKFARRQQERD-PGYFVPRCRKDGNFAAMQCYGNNG-CWCS 122
            :|...|:.:.:.|:|   :.|:...|:.:.|..:: ...|:|.|..||.::.:||:...| |||.
Mouse    70 KCKDPQLEIAHRGNCKDVSRCVAERKYTQEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCV 134

  Fly   123 DSQGRPIADDNKQFRRKGKLRCRANRRDRRRLASHQIGYNPDTSASKGSSEAGSTAHRT--CSKS 185
            ...||||:                                           ..:.||:|  |..|
Mouse   135 TPNGRPIS-------------------------------------------GTAVAHKTPRCPGS 156

  Fly   186 DRSQFNTNLMRMFRNEAQSFFRQPSLSDSHILEWQFSKLDTNGNKLLDRQEIRELKKVLRRNVKP 250
                                                               |.|  ||      |
Mouse   157 ---------------------------------------------------INE--KV------P 162

  Fly   251 RRCGRTFGKYCDVTKDANLNWLEWSVCFTKEFHNRSAVVNLLASSAATAPPHSTHYSIHNTNVNG 315
            :|.|.  ||...:                       .:.::|.|..|.||...|
Mouse   163 QREGA--GKAVSL-----------------------QIFSVLNSDDAAAPALET----------- 191

  Fly   316 HHRGHTNTIGTGVNPHSYSEDASGSEEHEDNYEDSATGYGGEEDDSQGADLPSSRTHIPSLYMLN 380
                                ...|.|      ||.|:.|                   |:|:...
Mouse   192 --------------------QPQGDE------EDIASRY-------------------PTLWTEQ 211

  Fly   381 SKPETASQDLENDSNCWMDQSVTLEEQGHGGKSVLFVPQCLPDGRYQRIQCYSSTSTSYCWCVNE 445
            .|......:..:.|:|..:....|||........:.:|:|...|.|:.:||:  .||.|||||..
Mouse   212 VKSRQNKTNKNSASSCDQEHQSALEEAKQPKNDNVVIPECAHGGLYKPVQCH--PSTGYCWCVLV 274

  Fly   446 DTGKSIPGTSVKNKRPQCDESVAV-----------RPMKGCTEPRKTQFLKELKAYLNTSLL--- 496
            |||:.|||||.:.::|:||.:...           ||::||...:|.:||..:...|:|.::
Mouse   275 DTGRPIPGTSTRYEQPKCDNTARAHPAKARDLYKNRPLQGCPGAKKHEFLTSVLDALSTDMVHAV 339

  Fly   497 --PSSTTG--SNSSMWKTDDERIATLSFVYLDKNKNKSWDRREWKNFRDLVTSASHLRRCGKKMP 557
              |||::|  |......|.:||:....|..||||.:....::|.|.|:..:...|..::|.||..
Mouse   340 SDPSSSSGRLSEPDPSHTLEERVVHWYFKLLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFV 404

  Fly   558 RYCDVNGDKKISLAEWLNCLQATPRE-SATTAK---PAQSNETAS----PKFQG 603
            .|||:|.||.|::.|.:.||..|..| .|.|.|   |..:.|::|    |:.||
Mouse   405 EYCDMNNDKSITVQELMGCLGVTREEGKANTRKRHTPRGNAESSSSNRQPRKQG 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	13/43 (30%)
		TY	88..139	CDD:238114	16/52 (31%)
		SPARC_Ca_bdg	180..274	CDD:287550	12/95 (13%)
		SPARC_EC	<219..281	CDD:238155	9/61 (15%)
		TY	396..463	CDD:238114	26/66 (39%)
Smoc2	XP_006524840.1	KAZAL	39..84	CDD:197624	13/44 (30%)
		Thyroglobulin_1	90..153	CDD:365863	21/105 (20%)
		Thyroglob_assoc	154..225	CDD:374657	25/210 (12%)
		TY	226..292	CDD:238114	26/67 (39%)
		EFh_SPARC_SMOC2	315..428	CDD:320020	36/112 (32%)
		EF-hand motif	359..390	CDD:320020	10/30 (33%)
		EF-hand motif	396..426	CDD:320020	13/29 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848459
Domainoid	1	1.000	59	1.000	Domainoid score	I10614
eggNOG	1	0.900	-	-		E1_KOG4578
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3783
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057719at2759
OrthoFinder	1	1.000	-	-		FOG0004129
OrthoInspector	1	1.000	-	-		otm44353
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3895
SonicParanoid	1	1.000	-	-		X2872
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890