DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment magu and fstl4

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	XP_021324571.1	Gene:	fstl4 / 571664	ZFINID:	ZDB-GENE-070127-3	Length:	825	Species:	Danio rerio

Alignment Length:	643	Identity:	117/643 - (18%)
Similarity:	191/643 - (29%)	Gaps:	266/643 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ATGKSDDQLMKLPACAAKQGECDDNEGPVCGTDGQTYPTRCHLLRAQCGGHQ-VSLKYSGSCNAC 80
            |||:::        |.. |..|.....||||:||:.|...|.|.|:.|...: :|..:|..|
Zfish    71 ATGRAE--------CVC-QERCHSTFVPVCGSDGRFYQNHCELYRSACVRRRTISALHSKHC--- 123

  Fly    81 LEAVKFARRQQERDPGYFVPRCRKDGNFAAMQCYGNNGCWCSDSQGRPIADDNKQFRRKGKLRCR 145
                 |.|                             |..|:      :|:.||
Zfish   124 -----FLR-----------------------------GDACT------MAEYNK----------- 137

  Fly   146 ANRRDRRRLASHQIGYNPDTSASKGSSEAGSTAHRTCSKSDRSQFNTNLMRMFRNEAQSFFRQPS 210
                    |.|..:...|.:|              |.:::..:|..|.::.||     ::|
Zfish   138 --------LKSILMDMQPQSS--------------TNAENSMAQRRTLVLNMF-----TYF---- 171

  Fly   211 LSDSHILEWQFSKLDTNGNKLLDRQEIRELK-KVLRRNVKPRRCGRTFGKYCDVTKDANLNW--- 271
                          |.|.:..:..:|:.|:. |....||......:...:|.|...|.:|..
Zfish   172 --------------DRNQDGRVSSEELAEISVKEHLENVLLECSMQDLLRYDDYNNDGHLTLQEL 222

  Fly   272 ------LEWSVCFTKEFHNRSAVVNL-----LASSAATAPP--------------------HSTH 305
                  :|.|:...:.....:..|.|     .|...:..||                    ....
Zfish   223 YTAFQVIELSLAEDRRLSVSTVTVGLSVVLSCAVQGSLRPPIIWKRNGIILNFLDLEDINDFGDD 287

  Fly   306 YSIHNTNVNGHHRGHTNTIGTGVNPHSYSEDASGSEEHEDNYEDSATGYGGEEDDSQGADLPSSR 370
            .|::.|.|...|.|                          ||...|.||  ||         .|:
Zfish   288 GSLYITKVTTIHMG--------------------------NYSCHAHGY--EE---------LSQ 315

  Fly   371 TH-----IPSLYMLNSKPETASQD-------------LENDSNCWMDQSVTLEEQGHGGKSVLFV 417
            ||     :|.:.::  .|||.:|:             :.|....|:...:.|  |.||.|.:
Zfish   316 THLLQVNVPPVILV--YPETQAQEPGVAASLRCHADGVPNPKLTWLKNGMDL--QPHGSKQI--- 373

  Fly   418 PQCLPDGRYQRIQC--YSSTSTSYCWCVNE-DTGKSIPGTSVKNKRPQC-------DESVAVRPM 472
             ..|.:|....|..  |..|....|...|| ...:.|....|::...:.       :|.::|..|
Zfish   374 -SLLANGSELHISSVRYEDTGAYTCIARNEVGVDEDISSLFVEDSARKTLANILWREEGLSVGNM 437

  Fly   473 ------KGCT--EPRKTQFLKEL---KAYLNT--SLLPS-STTGSNSSMWK-------------- 509
                  :|.|  :|...:..:.:   :..|.|  .|.|. |...|...:|.
Zfish   438 FYVFSNEGITVLQPGNCEIRRHITHTERILGTHEELCPRISGVSSQECVWSSAVSVREKYVFVSQ 502

  Fly   510 ----------TDDERI-------ATLSFVYLDKNKNKSWDRREWKNFRDLVTSASHLR 550
                      |..:|:       |....::.||:.::.|    ..::|||:.|.|.|:
Zfish   503 PLLNRLLVMDTQAQRVVQAVETDAMPVKLFYDKSHDQLW----VLSWRDLLKSRSTLQ 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	14/39 (36%)
		TY	88..139	CDD:238114	6/50 (12%)
		SPARC_Ca_bdg	180..274	CDD:287550	17/103 (17%)
		SPARC_EC	<219..281	CDD:238155	13/71 (18%)
		TY	396..463	CDD:238114	16/69 (23%)
fstl4	XP_021324571.1	KAZAL	78..123	CDD:197624	15/45 (33%)
		EF-hand_7	167..227	CDD:316058	14/82 (17%)
		Ig	250..308	CDD:319273	10/83 (12%)
		Ig2_Follistatin_like	342..417	CDD:143213	17/80 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910