DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment magu and fstl5

DIOPT Version :9

Sequence 1:	NP_610548.2	Gene:	magu / 36048	FlyBaseID:	FBgn0262169	Length:	613	Species:	Drosophila melanogaster
Sequence 2:	NP_001027012.2	Gene:	fstl5 / 566192	ZFINID:	ZDB-GENE-070127-1	Length:	854	Species:	Danio rerio

Alignment Length:	684	Identity:	124/684 - (18%)
Similarity:	199/684 - (29%)	Gaps:	305/684 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TGKSDDQLMKLPACAAKQGECDDNEGPVCGTDGQTYPTRCHLLRAQCGGHQ-VSLKYSGSCNACL 81
            ||:.:.|.::         .|..:..||||:||:.|...|.|.||.|..|| :::.:|..|
Zfish    89 TGEGECQCLE---------RCKPHYKPVCGSDGKLYQNHCELHRASCLAHQRITIMHSDEC---- 140

  Fly    82 EAVKFARRQQERDPGYFVPRCRKDGNFAAMQCYGNNGCWCSDSQGRPIADDNKQFRRKGKLRCRA 146
                |.:                                          |||          ||.
Zfish   141 ----FYK------------------------------------------DDN----------CRL 149

  Fly   147 NRRDRRRLASHQIGYNPD---TSASKGSSEAGSTAHRTCSKSDRSQFNTNLMRMFRNEAQSFFRQ 208
            .  |.::|.|..:..:..   |:|:.||.|....|.:
Zfish   150 G--DYKKLKSKMLDIHAQRYLTAANHGSHEKDMAARK---------------------------- 184

  Fly   209 PSLSDSHILEWQFSKLDTNGNKLLDRQEIRELKKVLRRNVKPRRCGRTFG--------KYCDVTK 265
                  |:::..|.:.|.:||..:|..|:.::       :|.....||..        ||.|:..
Zfish   185 ------HLVDMMFKRFDADGNGKVDSSELSQV-------IKQEGLSRTVSECTLFDLFKYNDIND 236

  Fly   266 DANLNWLEWSVCF---------------TKEFHNRSAVVNLLASSAATAPP-------HSTHY-- 306
            |.:|...|:...|               |.....:|||:. .|......||       |..:.
Zfish   237 DEHLAKEEFYAAFEVYQLSLPEEQKLSVTTVTVGQSAVLT-CAIMGDQRPPIIWRRNGHDLNMME 300

  Fly   307 -----------SIHNTNVNGHHRGH-------------TNTIGTGVNP----------------- 330
                       |::.|.|...|.|:             |:|:...|.|
Zfish   301 LEDINDFGDDGSLYITKVTTTHMGNYTCHADGYEQLFQTHTLQVNVPPVIRVYPESQAREPGVTA 365

  Fly   331 --HSYSE--------------------------DASGSEEHEDN--YEDS------ATGYGGEED 359
              ..|:|                          .|:|||.|..|  :||:      |....|.::
Zfish   366 SLRCYAEGIPDPQLSWLKNGMDITTKLSKQLTLQANGSEVHISNVHFEDTGAYTCIARNEAGVDE 430

  Fly   360 DSQGADLPSSRTHIPSLYMLNSKPETASQDLENDSNCWMDQSVTLEEQGHGGKSVLFVPQCLPDG 424
            |            |.||::.:|..:|.:..|      |       .|:|.|..::.:|  ...||
Zfish   431 D------------ISSLFVEDSARKTLANIL------W-------REEGLGIGNMFYV--FYEDG 468

  Fly   425 --RYQRIQC-----------YSSTSTSYCWCVNEDTGKSIPGTSVKNKRPQCDESVAVRPMKGCT 476
              ..|.:.|           ........|..|..:..:....||..|.
Zfish   469 IKVIQPVACEIQRHIKPSEKLLGLQEEVCPLVEGEMEQKCLWTSAVNV----------------- 516

  Fly   477 EPRKTQFLKELKAYLNTSLLPSSTTGSNSSMWKTDDERIATLSFVYLDKNKNK----SWDRREWK 537
               |.:|:...:..||..|:..  ..|..::.....:|:...  ::.||:.::    ||...| |
Zfish   517 ---KDKFIYATQPLLNRLLIVD--IQSQKAVQTVSTDRLPVK--LHYDKSHDQVWVLSWGDLE-K 573

  Fly   538 NFRDL--VTSAS--------HLRRCGKKMPRYCD 561
            ||..|  ::.||        |.:..|.:..|..|
Zfish   574 NFPTLQVISQASGSTSHHTIHTQPVGHRFDRVED 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
magu	NP_610548.2	KAZAL_FS	38..77	CDD:238052	16/39 (41%)
		TY	88..139	CDD:238114	3/50 (6%)
		SPARC_Ca_bdg	180..274	CDD:287550	15/101 (15%)
		SPARC_EC	<219..281	CDD:238155	17/84 (20%)
		TY	396..463	CDD:238114	14/79 (18%)
fstl5	NP_001027012.2	KAZAL	95..140	CDD:197624	17/53 (32%)
		EFh	187..245	CDD:238008	14/64 (22%)
		EF-hand_7	189..249	CDD:290234	15/66 (23%)
		IG_like	263..344	CDD:214653	15/81 (19%)
		IGc2	270..332	CDD:197706	12/62 (19%)
		I-set	348..437	CDD:254352	17/100 (17%)
		Ig2_Follistatin_like	365..440	CDD:143213	16/86 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910